Continuous Flow Techniques in Organic Synthesis

An automated method is described, using standard continuous flow techniques, for the determination of urine fluoride ion concentration using a fluoride ion selective electrode. It is shown that the kinetics of the electrode response to changes in fluoride ion can be used for the accurate measurement of fluoride ion concentration in urine, and that equilibration of the electrode response is not a prerequisite for the measurement of fluoride ion. Recovery experiments are in the range 83 to 90%; in-batch precision is between 0·9 and 1·6% and carryover 2·5% or less.

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Functional Group Interconversion Reactions in Continuous Flow Reactors

Current Organic Chemistry ◽

10.2174/1385272825666210610154414 ◽

2021 ◽

Vol 25 ◽

Author(s):

Alexander Leslie ◽

Angel Maria Joseph ◽

Marcus Baumann

Keyword(s):

Continuous Flow ◽

Functional Group ◽

Modern Synthesis ◽

Flow Reactors ◽

Flow Synthesis ◽

Specific Reaction ◽

Solid Foundation ◽

Continuous Flow Reactors ◽

Flow Techniques

: An overview of the current uptake of continuous flow techniques for various functional group interconversion reactions is presented. Besides highlighting a variety of prominent examples and their main features, this review provides insights into specific reaction classes, such as oxidations, reductions, rearrangements as well as different C-H functionalization processes. While this review can only include key examples from the last decade, the reader will find a solid foundation of important transformations along with further references to inform and appreciate the opportunities arising from modern synthesis technologies such as flow synthesis.

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ChemInform Abstract: Continuous Flow Organic Synthesis under High-Temperature/Pressure Conditions

ChemInform ◽

10.1002/chin.201033239 ◽

2010 ◽

Vol 41 (33) ◽

pp. no-no

Author(s):

Tahseen Razzaq ◽

C. Oliver Kappe

Keyword(s):

High Temperature ◽

Organic Synthesis ◽

Continuous Flow

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ChemInform Abstract: Propargyl Amine Synthesis Catalyzed by Gold and Copper Thin Films by Using Microwave-Assisted Continuous-Flow Organic Synthesis (MACOS).

ChemInform ◽

10.1002/chin.201020048 ◽

2010 ◽

Vol 41 (20) ◽

Author(s):

Gjergji Shore ◽

Woo-Jin Yoo ◽

Chao-Jun Li ◽

Michael G. Organ

Keyword(s):

Thin Films ◽

Organic Synthesis ◽

Continuous Flow ◽

Microwave Assisted

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Non-Aqueous Continuous-Flow Electrophoresis (NACFE): Separation Complement for Continuous-Flow Organic Synthesis

10.26434/chemrxiv.7840937.v3 ◽

2019 ◽

Author(s):

Nikita A. Ivanov ◽

Yimo Liu ◽

Sven Kochmann ◽

Sergey N. Krylov

Keyword(s):

Steady State ◽

Organic Synthesis ◽

Flow Separation ◽

Continuous Flow ◽

Organic Molecules ◽

Water Electrolysis ◽

Organic Salt ◽

Aqueous Electrolytes ◽

Differential Distribution ◽

Steady State Operation

<div>Continuous-flow organic synthesis naturally requires continuous-flow separation of reaction components. The most common continuous-flow separation approach is liquid-liquid extraction based on differential distribution of molecules between organic and aqueous phases. This approach has limited selectivity; it can hardly separate different hydrophobic organic molecules from each other. Continuous-flow electrophoresis can facilitate much more selective separation in a single phase, but it is currently limited to aqueous electrolytes which are incompatible with many hydrophobic organic molecules. Further, water electrolysis in aqueous electrolytes results in generation of large volumes of gas making steady-state operation a major technical challenge. Here, we introduce non-aqueous continuous-flow electrophoresis (NACFE) in which the electrolyte is a solution of an organic salt in an aprotic organic solvent. We demonstrate that NACFE can maintain stable separation of multiple species during 10 hours. The non-aqueous nature of NACFE and its ability to support steady-state operation make it suitable for its incorporation into continuous-flow organic synthesis.</div>

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