scholarly journals Frontispiece: Origin of the Regioselective Fatty-Acid Hydroxylation versus Decarboxylation by a Cytochrome P450 Peroxygenase: What Drives the Reaction to Biofuel Production?

2016 ◽  
Vol 22 (16) ◽  
Author(s):  
Abayomi S. Faponle ◽  
Matthew G. Quesne ◽  
Sam P. de Visser
Keyword(s):  
Cytochrome P450 ◽  
Fatty Acid ◽  
Biofuel Production ◽  
Fatty Acid Hydroxylation ◽  
Acid Hydroxylation

scholarly journals Substrate Recognition and Molecular Mechanism of Fatty Acid Hydroxylation by Cytochrome P450 fromBacillus subtilis

2003 ◽  
Vol 278 (11) ◽  
pp. 9761-9767 ◽  
Author(s):  
Dong-Sun Lee ◽  
Akari Yamada ◽  
Hiroshi Sugimoto ◽  
Isamu Matsunaga ◽  
Hisashi Ogura ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Fatty Acid ◽  
Molecular Mechanism ◽  
Substrate Recognition ◽  
Fatty Acid Hydroxylation ◽  
Acid Hydroxylation

scholarly journals Ceramide glycosylation and fatty acid hydroxylation influence serological reactivity inTrypanosoma cruziglycosphingolipids

2005 ◽  
Vol 244 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Maria Helena Villas-Boas ◽  
Robin Wait ◽  
Rosana B. Silva ◽  
Marcio L. Rodrigues ◽  
Eliana Barreto-Bergter
Keyword(s):  
Fatty Acid ◽  
Serological Reactivity ◽  
Fatty Acid Hydroxylation ◽  
Acid Hydroxylation

scholarly journals Metabolomics for the characterization of cytochromes P450-dependent fatty acid hydroxylation reactions in Arabidopsis

2009 ◽  
Vol 26 (1) ◽  
pp. 175-182 ◽  
Author(s):  
Kosuke Kai ◽  
Hiroko Hashidzume ◽  
Kazuya Yoshimura ◽  
Hideyuki Suzuki ◽  
Nozomu Sakurai ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cytochromes P450 ◽  
Fatty Acid Hydroxylation ◽  
Acid Hydroxylation

The stereochemistry of fatty acid hydroxylation by cytochrome P450BM3

2007 ◽  
Vol 48 (1) ◽  
pp. 133-136 ◽  
Author(s):  
Max J. Cryle ◽  
Nick J. Matovic ◽  
James J. De Voss
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Hydroxylation ◽  
Acid Hydroxylation

CYP52A23 from Candida albicans and its Substrate Preference for Fatty Acid Hydroxylation

2019 ◽  
Vol 671 ◽  
pp. 27-34 ◽  
Author(s):  
Hyoung-Goo Park ◽  
Vitchan Kim ◽  
Harim Kim ◽  
Rowoon Lee ◽  
Myung-A. Cho ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Fatty Acid ◽  
Substrate Preference ◽  
Fatty Acid Hydroxylation ◽  
Acid Hydroxylation

Understanding electron transport systems of Streptomyces cytochrome P450

2006 ◽  
Vol 34 (6) ◽  
pp. 1183-1185 ◽  
Author(s):  
Y.-J. Chun ◽  
T. Shimada ◽  
M.R. Waterman ◽  
F.P. Guengerich
Keyword(s):  
Cytochrome P450 ◽  
Electron Transport ◽  
Streptomyces Coelicolor ◽  
Genomic Analysis ◽  
Biologically Active ◽  
Transport Systems ◽  
Cytochrome P450 Enzymes ◽  
Streptomyces Spp ◽  
Fatty Acid Hydroxylation ◽  
Acid Hydroxylation

Streptomyces spp. are known to produce various types of biologically active compounds including antibiotics, antiparasitic agents, herbicides and immunosuppressants. P450 (cytochrome P450) enzymes may have key roles in these biosynthetic and biotransformation reactions. Recent genomic analysis of Streptomyces coelicolor A3(2) indicates that S. coelicolor may have six ferredoxins (Fdxs), four putative Fdx reductases (FdRs) and 18 P450 genes. However, there are few clues to explain the mechanisms and functions of Streptomyces P450 systems. To solve these questions, we have expressed and purified five S. coelicolor P450s, four FdRs and six Fdxs in Escherichia coli. Of the purified P450s, CYP105D5 has fatty acid hydroxylation activity in a system reconstituted with putidaredoxin reductase and Fdx4 or with spinach FdR and spinach Fdx, although the reconstitutions with FdR2 or FdR3 and any of the Fdxs did not support CYP105D5-catalysed oleic acid hydroxylation. Elucidation of the detailed mechanisms of electron transport system for Streptomyces P450 may provide the perspective for usefulness of P450s as a biocatalyst.

Sign in / Sign up

Export Citation Format

Share Document