Aim and Objective:
Microwave-assisted condensation of acetophenone 1 and aromatic aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the reaction with hydrazine hydrate and oxalic acid in
the presence of the catalytic amount of acetic acid in ethanol.
Materials and Methods:
The structural features of the synthesized compounds were characterized by melting point, FT-IR, 1H, 13C NMR and elemental analysis.
Results:
The antibacterial activities of the synthesized pyrazoles was evaluated against three gram-positive bacteria such as
Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria such as Escherichia coli and
Salmonella typhimurium.
Conclusion:
All the synthesized pyrazoles showed relatively high antibacterial activity against S. aureus strain and none of
them demonstrated antibacterial activity against E. coli.
Magnetic NiFe2O4 Nanoparticles Prepared via Non‐aqueous Microwave‐assisted Synthesis for Application in Electrocatalytic Water Oxidation
