ChemInform Abstract: SYNTHESIS OF 2-HYDROXY-3-(DIETHYLAMINO)PROPYL ESTERS OF SUBSTITUTED ACETIC ACIDS AND THEIR PHARMACOLOGICAL PROPERTIES

1983 ◽  
Vol 14 (41) ◽  
Author(s):  
O. L. MNDZHOYAN ◽  
A. A. GAMBURGYAN ◽  
A. U. ISAKHANYAN ◽  
S. S. VASILYAN ◽  
A. V. POGOSYAN ◽  
...  
Keyword(s):  
Pharmacological Properties ◽  
Propyl Esters ◽  
Acetic Acids

Inhibition of Cortical Neurones by Imidazole and Some Derivatives

1973 ◽  
Vol 51 (11) ◽  
pp. 790-797 ◽  
Author(s):  
J. M. Godfraind ◽  
K. Krnjević ◽  
H. Maretić ◽  
R. Pumain
Keyword(s):  
Cyclic Amp ◽  
Cyclic Nucleotide ◽  
Inhibitory Action ◽  
Aminobutyric Acid ◽  
Phosphodiesterase Activity ◽  
Inhibitory Potency ◽  
Imidazole Derivatives ◽  
Propyl Esters ◽  
Relative Potencies ◽  
Acetic Acids

Systematic tests of imidazole and 15 derivatives, applied by microiontophoresis in anesthetized cats, showed a high inhibitory potency of imidazole-4-acetic and imidazole-4-propionic acids and also of their amyl and propyl esters; but imidazole 4-carboxylic and 1-methylimidazole-4-acetic acids were largely inactive. This order of potency is very different from the relative potencies of imidazole derivatives in facilitating cyclic nucleotide phosphodiesterase activity. It is therefore unlikely that their inhibitory action is simply related to changes in cellular levels of cyclic AMP. The characteristics of this action, including lack of antagonism by bicuculline, are consistent with the possibility that it is mediated by γ-aminobutyric acid receptors.

scholarly journals The reactivity of propyl esters of 2-(benzoylamino)(1-R-2-oxoindoline-3-ylidene) acetic acids

2019 ◽  
Vol 17 (2(66)) ◽  
pp. 33-37
Author(s):  
O. M. Svechnikova ◽  
S. V. Kolisnyk ◽  
O. F. Vynnyk ◽  
O. O. Altukhov ◽  
T. A. Kostina
Keyword(s):  
Propyl Esters ◽  
Acetic Acids

Junction of the Epithelium and Lamina Propria of the Bovine Rumen Mucosa

1967 ◽  
Vol 25 ◽  
pp. 68-69
Author(s):  
Al W. Stinson
Keyword(s):  
Osmium Tetroxide ◽  
Squamous Epithelium ◽  
Short Chain Fatty Acids ◽  
Chloride Ions ◽  
Fermentation Products ◽  
Ruminant Species ◽  
Protective Shield ◽  
Stratified Squamous Epithelium ◽  
Lead Hydroxide ◽  
Acetic Acids

The stratified squamous epithelium which lines the ruminal compartment of the bovine stomach performs at least three important functions. (1) The upper keratinized layer forms a protective shield against the rough, fibrous, constantly moving ingesta. (2) It is an organ of absorption since a number of substances are absorbed directly through the epithelium. These include short chain fatty acids, potassium, sodium and chloride ions, water, and many others. (3) The cells of the deeper layers metabolize butyric acid and to a lesser extent propionic and acetic acids which are the fermentation products of rumen digestion. Because of the functional characteristics, this epithelium is important in the digestive process of ruminant species which convert large quantities of rough, fibrous feed into energy.Tissue used in this study was obtained by biopsy through a rumen fistula from clinically healthy, yearling holstein steers. The animals had been fed a typical diet of hay and grain and the ruminal papillae were fully developed. The tissue was immediately immersed in 1% osmium tetroxide buffered to a pH of 7.4 and fixed for 2 hrs. The tissue blocks were embedded in Vestapol-W, sectioned with a Porter-Blum microtome with glass knives and stained with lead hydroxide. The sections were studied with an RCA EMU 3F electron microscope.

Catalytic Enantioselective Benzylation Directly from Aryl Acetic Acids

2018 ◽  
Author(s):  
Patrick Moon ◽  
Zhongyu Wie ◽  
Rylan Lundgren
Keyword(s):  
Functional Group ◽  
Terminal Event ◽  
Radical Intermediates ◽  
Carbon Carbon Bond ◽  
Or Groups ◽  
Reaction Proceeds ◽  
Wide Availability ◽  
Metal Catalyzed ◽  
The Stability ◽  
Acetic Acids

The stability and wide availability of carboxylic acids make them valuable reagents in chemical synthesis. Most transition metal catalyzed processes using carboxylic acid substrates are initiated by a decarboxylation event that generates reactive carbanion or radical intermediates. Developing enantioselective methodologies relying on these principles can be challenging, as highly reactive species tend to react indiscriminately without selectivity. Furthermore, anionic or radical intermediates generated from decarboxylation can be incompatible with protic and electrophilic functionality, or groups that undergo trapping with radicals. We demonstrate that metal-catalyzed enantioselective benzylation reactions of allylic electrophiles can occur directly from aryl acetic acids. The reaction proceeds via a pathway in which decarboxylation is the terminal event, occurring after stereoselective carbon–carbon bond formation. The mechanistic features of the process enable enantioselective benzylation without the generation of a highly basic nucleophile. Thus, the process has broad functional group compatibility that would not be possible employing established protocols.<br>

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

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