ChemInform Abstract: Xanthoquinodin B3, a New Anticoccidial Agent Produced by Humicola sp. FO-888.

ChemInform ◽  
2010 ◽  
Vol 27 (35) ◽  
pp. no-no
Author(s):  
N. TABATA ◽  
H. TOMODA ◽  
Y. IWAI ◽  
S. OMURA
Keyword(s):  
Anticoccidial Agent

scholarly journals European field evaluation of monensin, a new anticoccidial agent

1974 ◽  
Vol 3 (1) ◽  
pp. 25-35 ◽  
Author(s):  
M.L. Clarke ◽  
M. Diaz ◽  
B. Guilloteau ◽  
P.L Hudd ◽  
J.W. Stoker
Keyword(s):  
Field Evaluation ◽  
Monensin A ◽  
Anticoccidial Agent

Asymmetric Total Synthesis of (+)-Coprophilin

Synthesis ◽  
2017 ◽  
Vol 50 (06) ◽  
pp. 1301-1306 ◽  
Author(s):  
Isamu Shiina ◽  
Yuma Umezaki ◽  
Takatsugu Murata ◽  
Kyohei Suzuki ◽  
Takayuki Tonoi
Keyword(s):  
Total Synthesis ◽  
Aldol Reaction ◽  
Alder Reaction ◽  
Diels Alder ◽  
Core Structure ◽  
Asymmetric Total Synthesis ◽  
Diels Alder Reaction ◽  
Anticoccidial Agent

In this paper, we report the first total synthesis of (+)-coprophilin, an anticoccidial agent, by constructing the chiral linear precursor via a Mukaiyama–Evans aldol reaction and a stereoselective intramolecular Diels–Alder reaction. The proposed method can be used to provide large amounts of (+)-coprophilin, which exhibits a 3,4,5,6,7-pentasubstituted Δ1,2-octalin core structure.

scholarly journals Beagle dog 90-day oral toxicity study of a novel coccidiostat – ethanamizuril

2020 ◽  
Author(s):  
Keyu Zhang ◽  
Xiaoyang Wang ◽  
Shuya Wei ◽  
Chunmei Wang ◽  
Mi Wang ◽  
...  
Keyword(s):  
Clinical Pathology ◽  
Dosage Level ◽  
Oral Toxicity ◽  
Safety Database ◽  
Clinical Observations ◽  
Adverse Effect Level ◽  
Effect Level ◽  
Anticoccidial Activity ◽  
Anticoccidial Agent ◽  
Histologic Changes

Abstract Background: Triazine coccidiostats are widely used in chickens and turkeys for coccidiosis control. Ethanamizuril is a novel triazine compound that exhibits anticoccidial activity in poultry. To support the safety assessment of the new potent anticoccidial agent, the subchronic toxicity of ethanamizuril was studied in beagle dogs administered ethanamizuril by diet at doses of 12, 60 or 300 mg/kg/day for 90 days.Results: Ethanamizuril was well tolerated at low and middle dosages and there were no ethanamizuril related effects on survival, clinical observations, clinical pathology parameters, organs weight, macroscopic or microscopic evaluations. The ethanamizuril related changes were limited to effects on food consumption and histologic changes of kidneys in the 300 mg/kg/day group in both sexes. However, the characteristic toxicities of ethanamizuril in kidneys are recoverable in convalescence dogs of 300 mg/kg/day group. Conclusions: Therefore, the no-observed-adverse-effect level (NOAEL) was considered to be 60 mg/kg/day, the middle dosage level tested. These results add to the safety database for ethanamizuril with potential for use as a novel coccidiostat.

scholarly journals Biological Studies on Nicarbazin, a New Anticoccidial Agent

1956 ◽  
Vol 35 (6) ◽  
pp. 1355-1367 ◽  
Author(s):  
W.H. Ott ◽  
S. Kuna ◽  
C.C. Porter ◽  
A.C. Cuckler ◽  
D.E. Fogg
Keyword(s):  
Biological Studies ◽  
Anticoccidial Agent

scholarly journals A Preliminary in vitro Study to Evaluate Poly-3-Hydroxy Butyrate as an Anticoccidial Agent against Oocysts of E. tenella

2018 ◽  
Vol 7 (08) ◽  
pp. 4364-4372
Author(s):  
T. Aadithya ◽  
S. Meignanalakshmi ◽  
M. Raman ◽  
M. Parthiban ◽  
K. Vijayarani
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Anticoccidial Agent

In Vitro Anticoccidial Activities of the Extract and Fractions of Garcinia kola (Heckel h.) against Eimeria tenella Oocyst

2021 ◽  
Vol 15 ◽  
Author(s):  
Manji Amos Shetshak ◽  
Isa Danjuma Jatau ◽  
Muhammed Musa Suleiman ◽  
Matthew Philip Ameh ◽  
Gabriel Ada ◽  
...  
Keyword(s):  
Cardiac Glycosides ◽  
Methanol Extract ◽  
Eimeria Tenella ◽  
Phytochemical Analysis ◽  
Garcinia Kola ◽  
Soxhlet Apparatus ◽  
Anticoccidial Agent ◽  
Garcinia Kola Heckel ◽  
Crude Methanol Extract

Background: Commercial poultry farming is expanding every day and contributing to the provision of affordable and high quality protein. However, this sector is confronted with many diseases of which coccidiosis is among the most important. There are many registered patents affirming the health benefits of Garcinia kola in poultry. Objective: Evaluation of In vitro anticoccidial activities of the extracts and fractions of Garcinia kola against Eimeria tenella oocyst was carried out. Method: Fresh seeds of G. kola were collected, dried under shade at room temperature and pulverized using a mortar and a pestle. The powder was exhaustively extracted with a soxhlet apparatus using 70% methanol and the crude methanol extract (CME) was concentrated to dryness using a rotary evaporator. The CME was further partitioned using butanol, ethylacetate and n-hexane. The CME, butanol fraction (BTF), ethylacetate fraction (EAF) and hexane fraction (HXF) were concentrated in vacuo and tested for the presence of phytochemical constituents using standard procedures. Similarly the CME, butanol, ethyl acetate and hexane fractions were evaluated in vitro for oocyst sporulation inhibition. Results: Phytochemical analysis revealed the presence of cardiac glycosides, saponins, carbohydrates, steroids/triterpenes, tannins, flavonoids and alkaloids in the CME and BTF. The EAF contains all the metabolites mentioned except saponins. Similarly, HXF contains only cardiac glycosides, tannins and steroids/triterpenes. The CME and BTF caused a concentration dependent increase in the inhibition of sporulation of unsporulated oocysts of E. tenella. In the acute toxicity studies, the CME did not produce any toxic effect or mortality at doses between 10 and 5000 mg/kg. The CME was then considered safe and the LD50 was assumed to be >5000 mg/kg. Conclusion: The data obtained in this study suggest that the crude methanol extract (CME) of G. kola could be appreciable beneficial effect as an anticoccidial agent against Eimeria tenella oocyst.

ChemInform Abstract: Coprophilin: An Anticoccidial Agent Produced by a Dung Inhabiting Fungus.

ChemInform ◽  
2010 ◽  
Vol 30 (17) ◽  
pp. no-no
Author(s):  
John G. Ondeyka ◽  
Robert A. Giacobbe ◽  
Gerald F. Bills ◽  
Cristina Cuadrillero ◽  
Dennis Schmatz ◽  
...  
Keyword(s):  
Anticoccidial Agent

Thin-Layer Chromatography/Bioautography Method for Detection of Monensin in Poultry Tissues

1989 ◽  
Vol 72 (5) ◽  
pp. 735-738 ◽  
Author(s):  
Perry A Vanderkop ◽  
James D Macneil
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Fatty Tissue ◽  
Simple Method ◽  
Residue Detection ◽  
Liver And Kidney ◽  
Anticoccidial Agent ◽  
Poultry Tissues ◽  
Lower Limits ◽  
Layer Chromatography

Abstract Monensin is an effective anticoccidial agent widely used in the poultry industry. Because of concerns over its toxicity, a sensitive, reliable, fast, and simple method for residue detection in poultry tissues is desirable from both a diagnostic and a regulatory view. Many methods of detection are excluded due to this ionophore's complex chemical and biological nature. A common method used for its detection is thin-layer chromatography/bioautography (TLC/B), although this is usually only semiquantitative. A new TLC/B method for monensin detection in poultry tissues was developed and is reported here. Recovery from cardiac muscle, skeletal muscle, and liver and kidney tissues is in the range of 93-97%. A detection limit of 250 Mg/kg with 99% reliability was achieved with this method. Lower limits (to 10 Mg/kg) were detectable, but with lower reliability (60%). Quantitative analysis is not possible on samples from fatty tissue.

Anticoccidial activity of herbal complex in broiler chickens challenged withEimeria tenella

Parasitology ◽  
2011 ◽  
Vol 139 (2) ◽  
pp. 237-243 ◽  
Author(s):  
MUHAMMAD A. ZAMAN ◽  
ZAFAR IQBAL ◽  
RAO Z. ABBAS ◽  
MUHAMMAD N. KHAN
Keyword(s):  
Broiler Chickens ◽  
Field Isolate ◽  
Eimeria Tenella ◽  
Calotropis Procera ◽  
Chemotherapeutic Drugs ◽  
Trachyspermum Ammi ◽  
Anticoccidial Activity ◽  
Anticoccidial Effect ◽  
Anticoccidial Agent ◽  
Pathogenic Effects

SUMMARYThe objective of the present study was to evaluate the anticoccidial effect of different concentrations of the herbal complex of 4 plants (leaves ofAzadirachta indicaandNicotiana tabacum,flowers ofCalotropis proceraand seeds ofTrachyspermum ammi) in broiler chickens in comparison with amprolium anticoccidial. Three concentrations (2 g, 4 g and 6 g) of herbal complex were given to the experimental groups once a day and amprolium (at the dose rate of 125 ppm) was given orally in drinking water from the 14th to the 21st days of age. One group was kept as infected, non-medicated control and one as non-infected, non-medicated control. All groups were inoculated orally with 75 000 sporulated oocysts on the 14th day of age except the non-infected, non-medicated control. Among herbal complex medicated groups, the maximum anticoccidial effect was seen in the group medicated with 6 g herbal complex followed by 4 g and 2 g herbal complex medicated groups. Treatment with 6 g of the herbal complex significantly reduced the negative performance and pathogenic effects associated withEimeria tenellachallenge at a level that was comparable with amprolium when using a largely susceptible recent field isolate. In summary, concentration-dependent anticoccidial activity of the studied herbal complex suggests its use as an alternative anticoccidial agent to chemotherapeutic drugs forEimeria tenellacontrol.

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