Anticoccidial Effect of Herbal Powder “Shi Ying Zi” in Chickens Infected with Eimeria tenella

Coccidiosis is one of the most economically important diseases affecting the poultry industry. Currently, anticoccidial drugs used in veterinary clinics show many deficiencies, and new control measures are urgently needed. This study presents an anticoccidial herbal powder “Shi Yin Zi”, which consists of Cnidium monnieri (L.) Cuss, Taraxacum mongolicum Hand.-Mazz., and sodium chloride. In chickens infected with Eimeria tenella, supplementation with “Shi Yin Zi” powder for 3 d prior to infection or treatment with “Shi Yin Zi” powder after infection could improve the survival rate and relative growth rate and alleviate the pathological changes in the cecum, liver, and kidney. “Shi Yin Zi” powder could recover the levels of alanine aminotransferase, creatinine, albumin, and triglycerides in serum. The hemorrhage occurrence and total number of oocysts in feces were reduced. The anti-coccidial indexes reached 165 for the prophylactic effect and 144 for the therapeutic effect. The anti-coccidial effects were equal to positive controls (monensin and sulfamlopyrazine). These results suggest that “Shi Ying Zi” powder possesses a potent anticoccidial effect and exhibits the potential to control E. tenella infection.

Anticoccidial effect of “Shi Ying Zi” Powder in chickens infected with Eimeria tenella

Background: Coccidiosis is one of the most economically important diseases affecting the poultry industry. Currently, anticoccidial drugs used in veterinary clinical showed many deficiencies, and new control measures are urgently needed. Many plant-derived drugs, such as herbal extracts, showed effects with less drug residues and resistance. Development of herbal medicine as the anticoccidial drug is one of the most prospective method for treating coccidiosis.Methods:“Shi Ying Zi” is the herbal powder that consisted of Cnidium monnieri (L.) Cuss, Taraxacum mongolicum Hand-Mazz and salt with the proportion of 55: 40: 5 (g/g/g). 200 1-day-old broiler chicks free of coccidiosis were equally divided into 10 groups: normal group, untreated group, 4 protective groups (positive control group and three “Shi Ying Zi” powder groups) and 4 therapeutical groups (positive control group and three “Shi Ying Zi” powder groups). At 11 th day of age, the chicks in the four protective groups were prophylactically supplemented with “Shi Ying Zi” powder at the doses of 5g/kg, 10g/kg and 15g/kg and monensin (100mg/kg), respectively. At 14 th day of age, chicks except those in blank group were inoculated with 2×10 4 sporulated oocysts of E. tenella . When the first hemorrhagic fecal was found, therapeutical drugs started administration. The low (5g/kg), medium (10g/kg) and high doses (15g/kg) of “Shi Ying Zi” powder were added into the diet, respectively. Sulfachloropyrazine sodium (positive control) was added into water (1g/L). The anti-coccidial index, biochemical parameters and tissue lesions were determined from 4 d post infection to 8 d post infection. Results: Supplement with “Shi Yin Zi” powder for 3d prior to infection or after infection could improve the survival rate and relative growth rate and alleviate the pathological changes in the cecum, liver and kidney. “Shi Yin Zi” powder could recover the contents of glutamic-pyruvic transaminase, creatinine, albumin and triglycerides in serum. The hemorrhage and total number of oocysts in feces were reduced. The anti-coccidial index reaches to 165. The anti-coccidial effects were equal to positive controls (monensin and sulfamlopyrazine). Conclusions: “Shi Ying Zi” powder possesses potent anticoccidial effect and exhibits the potential to control E.tenella infection.

Anticoccidial effect of "Shi Ying Zi" Powder in chickens infected with Eimeria tenella

BackgroundCoccidiosis is one of the most economically important diseases affecting the poultry industry. Currently, anticoccidial drugs used in veterinary clinical showed many deficiencies, and new control measures are urgently needed. Many plant-derived drugs, such as herbal extracts, showed effects with less drug residues and resistance. Development of herbal medicine as the anticoccidial drug is one of the most prospective method for treating coccidiosis.Methods“Shi Ying Zi” powder is consisted of Cnidium monnieri (L.) Cuss, Taraxacum mongolicum Hand-Mazz and salt with the proportion of 55: 40: 5 (g/g/g). 200 1-day-old broiler chicks free of coccidiosis were equally divided into 10 groups: normal group, untreated group, 4 protective groups (positive control group and three “Shi Ying Zi” powder groups) and 4 therapeutical groups (positive control group and three “Shi Ying Zi” powder groups). At 11th day of age, the chicks in the four protective groups were prophylactically supplemented with “Shi Ying Zi” powder at the doses of 5g/kg, 10g/kg and 15g/kg and monensin (100mg/kg), respectively. At 14th day of age, chicks except those in blank group were inoculated with 2×104 sporulated oocysts of E. tenella. When the first hemorrhagic fecal was found, therapeutical drugs started administration. The low (5g/kg), medium (10g/kg) and high doses (15g/kg) of “Shi Ying Zi” powder were added into the diet, respectively. Sulfachloropyrazine sodium (positive control) was added into water (1g/L). The anti-coccidial index, biochemical parameters and tissue lesions were determined from 4 d post infection to 8 d post infection.ResultsSupplement with “Shi Yin Zi” powder for 3d prior to infection or after infection could improve the survival rate and relative growth rate and alleviate the pathological changes in the cecum, liver and kidney. “Shi Yin Zi” powder could recover the contents of glutamic-pyruvic transaminase, creatinine, albumin and triglycerides in serum. The hemorrhage and total number of oocysts in feces were reduced. The anti-coccidial index reaches to 165. The anti-coccidial effects were equal to positive controls (monensin and sulfamlopyrazine). Conclusions“Shi Ying Zi” powder possesses potent anticoccidial effect and exhibits the potential to control E.tenella infection.