ChemInform Abstract: A Facile Synthesis of 3′-Deoxy-3′-fluorothymidine via a Highly Stereoselective Glycosylation with 2,3-Dideoxy-3-fluoro-D-erythro-pentofuranosyl Diethyl Phosphite.

ChemInform ◽  
2010 ◽  
Vol 30 (46) ◽  
pp. no-no
Author(s):  
Jun Inagaki ◽  
Hiroki Sakamoto ◽  
Makoto Nakajima ◽  
Seiichi Nakamura ◽  
Shunichi Hashimoto
Keyword(s):  
Diethyl Phosphite ◽  
Facile Synthesis ◽  
Stereoselective Glycosylation

A Facile Synthesis of 3′-Deoxy-3′-fluorothymidine via a Highly Stereoselective Glycosylation with 2,3-Dideoxy-3-fluoro-d-erythro-pentofuranosyl Diethyl Phosphite

Synlett ◽  
1999 ◽  
Vol 1999 (8) ◽  
pp. 1274-1276 ◽  
Author(s):  
Jun Inagaki ◽  
Hiroki Sakamoto ◽  
Makoto Nakajima ◽  
Seiichi Nakamura ◽  
Shunichi Hashimoto
Keyword(s):  
Diethyl Phosphite ◽  
Facile Synthesis ◽  
Stereoselective Glycosylation

Biotemplated facile synthesis of three‐dimensional micro/nanoporous tin oxide: improving the flammable and mechanical properties of flexible PVC

2019 ◽  
Vol 14 (8) ◽  
pp. 828-830 ◽  
Author(s):  
Weihua Meng ◽  
Weihong Wu ◽  
Weiwei Zhang ◽  
Luyao Cheng ◽  
Yunhong Jiao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tin Oxide ◽  
Three Dimensional ◽  
Facile Synthesis

Selective Degradation of Grindelic Acid and Its 3α-Hydroxy Analog: Facile Synthesis of Grindelistrictic Acids and Potential Intermediates for Erigerol

Synlett ◽  
1991 ◽  
Vol 1991 (09) ◽  
pp. 725-727 ◽  
Author(s):  
Takeshi Shimizu ◽  
Sayoko Hiranuma ◽  
Zhao-hui Qian ◽  
Hirosuke Yoshioka
Keyword(s):  
Facile Synthesis ◽  
Selective Degradation

A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE

2015 ◽  
Vol 12 (1) ◽  
pp. 3910-3918 ◽  
Author(s):  
Dr Remon M Zaki ◽  
Prof Adel M. Kamal El-Dean ◽  
Dr Nermin A Marzouk ◽  
Prof Jehan A Micky ◽  
Mrs Rasha H Ahmed
Keyword(s):  
Biological Activity ◽  
Carbonyl Compounds ◽  
Mass Spectra ◽  
The Other ◽  
Pyridine Derivatives ◽  
Facile Synthesis ◽  
High Biological Activity ◽  
Basic Hydrolysis ◽  
Pyridine Carboxylate ◽  
Hydrolysis Of

 Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f  which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound 7-16. All the newly synthesized compounds were established by elemental and spectral analysis (IR, 1H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.

S(IV)–Mediated Unsymmetrical Heterocycle Cross-Couplings

2019 ◽  
Author(s):  
Min Zhou ◽  
Jet Tsien ◽  
Tian Qin
Keyword(s):  
Cross Coupling ◽  
Reductive Elimination ◽  
Facile Synthesis ◽  
Trigonal Bipyramidal

<p>Herein we report a sulfur (IV) mediated cross-coupling for facile synthesis of heteroaromatic substrates. Addition of heteroaryl nucleophiles onto a simple, readily-accessible alkyl sulfinyl (IV) chloride allows formation of a trigonal bipyramidal sulfurane intermediate. Reductive elimination therefrom provides bis-heteroaryl products in a practical and efficient fashion. <br></p>

Facile Synthesis of a Diverse Library of Mono-3-substituted β-Cyclodextrin Analogues

2018 ◽  
Author(s):  
Kathryn Kellett ◽  
Brendan M. Duggan ◽  
Michael Gilson
Keyword(s):  
High Yield ◽  
Facile Synthesis ◽  
Wide Range

We have described simple, high-yield, protocols, which require only commonly accessible equipment, to synthesize a wide range of β-CD derivatives mono-substituted at the secondary face. These derivatives may be useful in their own right, and they are also scaffolds for further modification, and examples of the far broader array of derivatives that may be accessed by these procedures.

Indium Bromide-catalyzed Unprecedented Hydrogenolysis: A Novel One-Pot Synthesis of Per-O-Acetylated β-carboxymethyl O and S-glycosides

2020 ◽  
Vol 24 (8) ◽  
pp. 900-908
Author(s):  
Ram Naresh Yadav ◽  
Amrendra K Singh ◽  
Bimal Banik
Keyword(s):  
Asymmetric Synthesis ◽  
Chiral Auxiliary ◽  
Bioactive Molecules ◽  
One Pot ◽  
Enantiomerically Pure ◽  
Stereoselective Glycosylation ◽  
One Pot Synthesis ◽  
Wide Range

Numerous O (oxa)- and S (thia)-glycosyl esters and their analogous glycosyl acids have been accomplished through stereoselective glycosylation of various peracetylated bromo sugar with benzyl glycolate using InBr3 as a glycosyl promotor followed by in situ hydrogenolysis of resulting glycosyl ester. A tandem glycosylating and hydrogenolytic activity of InBr3 has been successfully investigated in a one-pot procedure. The resulting synthetically valuable and virtually unexplored class of β-CMGL (glycosyl acids) could serve as an excellent potential chiral auxiliary in the asymmetric synthesis of a wide range of enantiomerically pure medicinally prevalent β-lactams and other bioactive molecules of diverse medicinal interest.

Green and Facile Synthesis of 1,4-Disubstituted 1,2,3-Triazoles via a Click Reaction of α-Bromo Ketones, [bmim]N3 and Terminal Acetylenes

2013 ◽  
Vol 10 (10) ◽  
pp. 738-743 ◽  
Author(s):  
Azadeh Fazeli ◽  
Hossein Oskooie ◽  
Yahya Beheshtiha ◽  
Majid Heravi ◽  
Hassan Valizadeh
Keyword(s):  
Click Reaction ◽  
Facile Synthesis ◽  
Terminal Acetylenes
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