ChemInform Abstract: A Synthesis of α-Amino Acids via Direct Reductive Carboxylation of Imines with Carbon Dioxide.

ChemInform ◽  
2013 ◽  
Vol 44 (38) ◽  
pp. no-no
Author(s):  
Ajay A. Sathe ◽  
Douglas R. Hartline ◽  
Alexander T. Radosevich
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Reductive Carboxylation

A synthesis of α-amino acids via direct reductive carboxylation of imines with carbon dioxide

2013 ◽  
Vol 49 (44) ◽  
pp. 5040 ◽  
Author(s):  
Ajay A. Sathe ◽  
Douglas R. Hartline ◽  
Alexander T. Radosevich
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Reductive Carboxylation

scholarly journals The nature of carbon dioxide substrate and equilibrium constant of the 6-phosphogluconate dehydrogenase reaction

1969 ◽  
Vol 115 (4) ◽  
pp. 633-638 ◽  
Author(s):  
R. H. Villet ◽  
K. Dalziel
Keyword(s):  
Carbon Dioxide ◽  
Free Energy ◽  
Equilibrium Constant ◽  
Heat Of Reaction ◽  
Phosphogluconate Dehydrogenase ◽  
Sheep Liver ◽  
Dehydrogenase Reaction ◽  
Reductive Carboxylation ◽  
Primary Substrate

1. It was shown that dissolved CO2 and not HCO3− or H2CO3 is the primary substrate for reductive carboxylation with 6-phosphogluconate dehydrogenase from sheep liver. 2. The equilibrium constant of the reaction was measured in solutions of various ionic strengths and at several temperatures, and the free energy and heat of reaction were determined.

Adsorption of carbon dioxide on naturally occurring solid amino acids

2016 ◽  
Vol 4 (3) ◽  
pp. 3170-3176 ◽  
Author(s):  
Sreedipta Chatterjee ◽  
Sadhana Rayalu ◽  
Spas D. Kolev ◽  
Reddithota J. Krupadam
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Naturally Occurring

COMPETITION BETWEEN AMINO ACIDS FOR TRANSPORT INTO EHRLICH ASCITES CARCINOMA CELLS

1961 ◽  
Vol 39 (11) ◽  
pp. 1717-1735 ◽  
Author(s):  
P. G. Scholefield
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Amino Acid ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Transport Systems ◽  
Radioactive Carbon ◽  
Ehrlich Ascites ◽  
Competitive Inhibitors ◽  
Amino Acid Analogues

The cumulative entry of amino acids into Ehrlich ascites carcinoma cells is due to the presence of active transport systems, each with its own specific range of substrates. Several amino acids and amino acid analogues may have an affinity for the same transport system and thus may inhibit transport of other amino acids by acting as competitive inhibitors or competitive substrates. Loss of methionine from ascites cells takes place by a diffusion process which obeys Fick's law. Leucine accumulation by ascites cells is small and is increased on addition of certain other amino acids. The increase is not due to inhibition of leucine oxidation as increase in the rate of production of radioactive carbon dioxide from labeled leucine also occurs. Kinetic aspects of these results are discussed.

scholarly journals Nickel-Catalyzed β-Carboxylation of Ynamides with Carbon Dioxide

Synlett ◽  
2019 ◽  
Vol 30 (09) ◽  
pp. 1048-1052 ◽  
Author(s):  
Ryohei Doi ◽  
Taichi Okano ◽  
Iman Abdullah ◽  
Yoshihiro Sato
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Magnesium Salt ◽  
Reaction Efficiency

A nickel-catalyzed β-selective hydrocarboxylation of ynamides to give protected dehydro-β-amino acids was developed. The key to exclusive β-selectivity was the use of diethylzinc as a reductant in the presence of a magnesium salt. The reaction was conducted with bis(acetylacetonato)nickel(II) instead of costly and sensitive bis(1,5-cyclooctadiene)nickel(0). In addition, the optimized ligand was inexpensive 1,5-cyclooctadiene. Investigation of the substrate scope revealed that both nitrogen and alkyne substituents have marked effects on the reaction efficiency. We obtained experimental clues that indicated the formation of a vinylzinc intermediate that forms a C–C bond with CO2.

Derivatization of Chiral Amino Acids in Supercritical Carbon Dioxide

2004 ◽  
Vol 76 (3) ◽  
pp. 736-741 ◽  
Author(s):  
María del Mar Caja López ◽  
Gracia P. Blanch ◽  
Marta Herraiz
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Supercritical Carbon Dioxide ◽  
Chiral Amino Acids ◽  
Supercritical Carbon

THE ESTIMATION OF FREE AMINO ACIDS USING A MICRODIFFUSION TECHNIQUE

1952 ◽  
Vol 30 (7) ◽  
pp. 522-528 ◽  
Author(s):  
W. B. McConnell
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Free Amino Acids ◽  
Free Amino ◽  
The Other ◽  
Routine Analysis ◽  
Average Deviation ◽  
Substantial Saving ◽  
Ionic Concentrations ◽  
The Mean

The carbon dioxide evolved when α-amino acids were heated for one hour at 85 °C. with ninhydrin was determined in a partially evacuated microdiffusion cell. Distillation of solvent from one chamber to the other was minimized by keeping the ionic concentrations of the reaction mixture and absorbing mixture approximately equal. The method was useful for samples of amino acids which liberated from 0.06 to 0.3 mgm. of carbon dioxide. The average deviation from the mean was somewhat less than 1% for samples liberating 0.2 mgm. of carbon dioxide. Use of the method for routine analysis of enzymatic digests resulted in substantial saving of time and material.

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