ChemInform Abstract: L-Proline-Catalyzed Unusual Product Formation from the Reaction of 4- Hydroxydithiocoumarin and Aldehydes Through a Pseudo-Three-Component Reaction.

ChemInform ◽  
2015 ◽  
Vol 46 (15) ◽  
pp. no-no
Author(s):  
Karuna Mahato ◽  
Prasanta Ray Bagdi ◽  
Abu T. Khan
Keyword(s):  
Product Formation ◽  
Three Component Reaction ◽  
Unusual Product

Unusual product formation in a 1,1-carboboration reaction

2015 ◽  
Vol 51 (40) ◽  
pp. 8436-8438 ◽  
Author(s):  
Christina Eller ◽  
Gerald Kehr ◽  
Constantin G. Daniliuc ◽  
Gerhard Erker
Keyword(s):  
Product Formation ◽  
Unusual Product ◽  
The Cross

The reaction of the cross-conjugated enediyne Me2CC(CCSiMe3)2with B(C6F5)3gives the unusual borabicyclo[4.3.0]nonadiene product.

scholarly journals Synthesis of pyrazolopyridine and pyrazoloquinoline derivatives by one-pot, three-component reactions of arylglyoxals, 3-methyl-1-aryl-1H-pyrazol-5-amines and cyclic 1,3-dicarbonyl compounds in the presence of tetrapropylammonium bromide

2019 ◽  
Vol 8 (1) ◽  
pp. 533-541 ◽  
Author(s):  
Ahmad Poursattar Marjani ◽  
Jabbar Khalafy ◽  
Somayeh Akbarzadeh
Keyword(s):  
Product Formation ◽  
One Pot ◽  
Dicarbonyl Compounds ◽  
Synthetic Strategy ◽  
Tetrapropylammonium Bromide ◽  
Three Component Reaction ◽  
Clean Product ◽  
Intramolecular Condensation ◽  
High Yields ◽  
Work Up

Abstract Pyrazolopyridine and pyrazoloquinoline derivatives were obtained by a one-pot, three-component reaction of arylglyoxals, 3-methyl-1-aryl-1H-pyrazol-5-amines and cyclic 1,3-dicarbonyl compounds in the presence of tetrapropylammonium bromide at 80°C in water through Knoevenagel and Micheal reactions, followed by intramolecular condensation, unexpected dearoylation and oxidation. Mild reaction conditions, high yields, simplicity of work up procedure, starting materials availability and clean product formation are some of the main advantages of this synthetic strategy.

ChemInform Abstract: Unusual Product Formation in a 1,1-Carboboration Reaction.

ChemInform ◽  
2015 ◽  
Vol 46 (39) ◽  
pp. no-no
Author(s):  
Christina Eller ◽  
Gerald Kehr ◽  
Constantin G. Daniliuc ◽  
Gerhard Erker
Keyword(s):  
Product Formation ◽  
Unusual Product

Amidolytic Detection of Prothrombin Activation Products after SDS-Gel Electrophoresis

1989 ◽  
Vol 61 (03) ◽  
pp. 386-391 ◽  
Author(s):  
Guido Tans ◽  
Truus Janssen-Claessen ◽  
Jan Rosing
Keyword(s):  
Gel Electrophoresis ◽  
Activated Protein C ◽  
Factor Xa ◽  
Coagulation Factors ◽  
Product Formation ◽  
Chromogenic Substrate ◽  
Nitrocellulose Membrane ◽  
Activation Products ◽  
Factor Xia ◽  
Prothrombin Activation

SummaryIn this paper we report a method via which enzymatically active products formed during prothrombin activation can be detected by simple photographic means after SDS-gel electrophoresis, blotting onto a nitrocellulose membrane and visualization with the chromogenic substrate, S2238. After amidolytic detection the same nitrocellulose membrane can also be used for immunologic detection of prothrombin activation products, thus allowing a complete description of product formation during prothrombin activation.The detection limit of the so-called “amidoblot” is approximately 3 ng thrombin per gel sample which is comparable to the sensitivity of immunoblotting.It is further shown that the amidoblot technique can also be applied to other coagulation factors for which a suitable chromogenic substrate is available (factor XIIa, kallikrein, factor XIa, factor Xa, plasmin and activated protein C).

THE INFLUENCE OF ETHANOL ON THE CONVERSION OF PREGNENOLONE TO PROGESTERONE BY HUMAN PLACENTAL MICROSOMES

1974 ◽  
Vol 76 (1) ◽  
pp. 178-188 ◽  
Author(s):  
H. Lübbert ◽  
K. Pollow ◽  
R. Wagner ◽  
J. Hammerstein
Keyword(s):  
Kinetic Parameters ◽  
Enzyme Preparation ◽  
Ethanol Concentration ◽  
Hydroxysteroid Dehydrogenase ◽  
Product Formation ◽  
Linear Increase ◽  
Maximal Velocity ◽  
Microsomal Enzyme ◽  
Temperature Optima ◽  
Substrate Concentrations

ABSTRACT The effects of ethanol on kinetic parameters of placental Δ5-3β-hydroxysteroid dehydrogenase were studied. In the presence of high pregnenolone concentrations (50 μm, [S] > Km) the microsomal enzyme preparation exhibited an almost linear increase in activity as the ethanol concentration in the medium was raised from 2.5 to 15 % (v/v). At lower substrate concentrations ([S] << Km) ethanol caused inhibition. Other effects of ethanol were: linearity of product formation with time was prolonged; the maximal velocity was markedly increased; the Km for pregnenolone slightly decreased with increasing ethanol concentrations (2.5 to 10 %, v/v) whereas the Km for NAD remained the same. The pH and temperature optima of the reaction were unaffected by ethanol. Other organic solvents caused similar effects.

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