Bathing or not Bathing: Which is better for Umbilical Cord Separation Time and Bacterial Colonization in Neonates?

Background: Sepsis is the third cause of death in the first month of life, and the umbilical cord is an important source for sepsis Objectives: We compared the effects of bathing or not bathing on bacterial colonization and cord separation time. Methods: A quasi-experimental study assessed term newborns at Golestan hospital, Tehran, Iran, from 2019 to 2020 in three groups. Bath (B) group included neonates who were bathed with tub water every two days (n = 90). Clean product (CP) group neonates were bathed with cleaners every two days (n = 87). Dry care cord (D) group neonates were not bathed during the first 10 days (n = 63). Periumbilical cord swabs were collected on the 10th day and cultured in blood agar and Eosin methylene blue agar. Bacterial sensitivity tests were done by disk diffusion. Results: The average time to cord separation was 8.2 ± 1.74 days (group B: 9.1 ± 2.1 days, group CP: 8.7 ± 1.82 days, group D: 6.8 ± 1.3 days), which was shorter in group D (P= 0.048). The positive culture rates were 77.8% in group B, 78.1% in group CP, and 74.6% in group D, which were not significantly different between the groups (P = 0.073). Staphylococcus aureus was the most common isolated species. Staphylococcus epidermis and Escherichia coli were the other most common species. Conclusions: Bathing with or without cleaners is safe. Non-bathing does not increase the umbilical positive culture. Therefore, in the first week, if a mother does not believe in bathing her baby, she should not be denounced and told that she did something wrong with cord hygiene.

Prototipo limpiador de frijol aplicando dispositivos lógicos programables

The project focuses on the cleaning of beans through the separation of impurities by screening machines, with the aim of helping small farmers who grow and sell their beans. Beans are among the most comsumed foods; however, the cleaning process is tedious, so we want to develop a system that performs such process in different stages of selection. Grains vary in price and quality in different places due to the conditions in which they are sold. This is because when they are sold in a supermarket, the product must be considered first level, which means, they must be of a homogeneous size and clean of any type of garbage. The purpose of this prototype is to clean the beans in such a way that it separates the impurities they might have and obtain a clean product. We begin by defining the cleaning procedure, then performing the structure and placement of sensors and actuators, and finally the programming and adjustments necessary for its operation. With this prototype, people who cultivate and extract the seeds can perform the cleaning and generate greater profits.

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL 5-ARYLIDENE-2-IMINO-3-(2- PHENYL- 1,8-NAPHTHYRIDIN-3-YL)THIAZOLIDIN-4-ONES

Objectives: Nowadays, antimicrobial resistance represents one of the most significant challenges in the medical community. To overcome the problem, it requires the discovery of newer safe and effective molecules against infectious sickness. Synthesis and screening of 1,8-naphthyridines have attracted much attention over the decades since it plays a key role against the microorganisms. Methods: 1,8-naphthyridine based 5-arylidene derivatives of thiazolidinone (3a-i) has been achieved by the cyclization reaction of 2-chloro-N- (2-phenyl-1,8-naphthyridin-3-yl)acetamide (1) with potassium thiocyanate in acetone followed by its Knoevenagel condensation reaction with appropriate arylaldehydes in ethanol. All the resulting products were confirmed using spectral and physicochemical data. Antibacterial activity was performed against different bacterial strains by agar disc diffusion method using ciprofloxacin as standard. Results: Compound 3b showed tremendous antibacterial activity among all the tested compounds. Conclusions: This study provides several advantages such as shorter reaction times, clean product, and good yields. Most of the final products possessed moderate to excellent antibacterial activity.

Synthesis of pyrazolopyridine and pyrazoloquinoline derivatives by one-pot, three-component reactions of arylglyoxals, 3-methyl-1-aryl-1H-pyrazol-5-amines and cyclic 1,3-dicarbonyl compounds in the presence of tetrapropylammonium bromide

Pyrazolopyridine and pyrazoloquinoline derivatives were obtained by a one-pot, three-component reaction of arylglyoxals, 3-methyl-1-aryl-1H-pyrazol-5-amines and cyclic 1,3-dicarbonyl compounds in the presence of tetrapropylammonium bromide at 80°C in water through Knoevenagel and Micheal reactions, followed by intramolecular condensation, unexpected dearoylation and oxidation. Mild reaction conditions, high yields, simplicity of work up procedure, starting materials availability and clean product formation are some of the main advantages of this synthetic strategy.

A novel biocompatible antibacterial product: Nanoliposomes loaded with poly(hexamethylene biguanide chloride)

In this study, nanoliposome-loaded poly(hexamethylene biguanide) is introduced as a novel biocompatible antibacterial product with higher activity than microliposomes. Soy lecithin as a clean product was used to prepare various nanoliposomes through sonication, high-pressure homogenizer, and normal homogenizer and also microliposomes through two methods of lipid film hydration and incubation methods. The nanoliposomes were formed under sonication with the size of 50 nm. The prepared liposomes were then loaded with poly(hexamethylene biguanide chloride) and the inclusion percentage was measured. The release profile of liposomes in buffer showed a release of 92% for poly(hexamethylene biguanide) during 24 h. The loaded liposomes were characterized with particle size analyzer, nuclear magnetic resonance, X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy. The antibacterial properties of different micro and nanoliposomes were investigated against a Gram-negative ( Escherichia coli) and a Gram-positive ( Staphylococcus aureus) bacteria. The poly(hexamethylene biguanide)–loaded nanoliposomes indicated higher antibacterial activities than microliposomes. Nanoliposomes have the potential to entrap lower poly(hexamethylene biguanide) dosages while retaining optimum therapeutic efficacy in the target site having lower cytotoxicity with lower side effects. The cytotoxicity of poly(hexamethylene biguanide) entrapped in liposomes was studied in human dermal fibroblasts and compared with free poly(hexamethylene biguanide) and blank liposomes. The maximum cytotoxicity was observed for free poly(hexamethylene biguanide) that is substantially decreased through loading within liposomes structure. Overall, the encapsulation of poly(hexamethylene biguanide) in liposomes improved the biocompatibility and safety of the product introducing a useful biocompatible antibacterial polymer for treatments of infectious diseases.

Clauson Kaas Pyrrole Synthesis Catalyzed by Acidic Ionic Liquid under Microwave Irradiation

A new procedure to synthesize the N-substituted pyrrole derivatives by Clauson Kaas reaction catalyzed by acidic ionic liquid under microwave irradiation was developed. This procedure provides several advantages such as high yield, clean product formation, and short reaction time.