scholarly journals Involvement of the extracellular matrix proteins periostin and tenascin C in nasal polyp remodeling by regulating the expression of MMPs

2021 ◽  
Vol 11 (7) ◽  
Author(s):  
Kun Du ◽  
Min Wang ◽  
Nan Zhang ◽  
Pei Yu ◽  
Ping Wang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Nasal Polyp ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Tenascin C

Tenascin-C modulates tumor stroma and monocyte/macrophage recruitment but not tumor growth or metastasis in a mouse strain with spontaneous mammary cancer

1999 ◽  
Vol 112 (12) ◽  
pp. 1855-1864 ◽  
Author(s):  
J.F. Talts ◽  
G. Wirl ◽  
M. Dictor ◽  
W.J. Muller ◽  
R. Fassler
Keyword(s):  
Extracellular Matrix ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Mouse Strain ◽  
Extracellular Matrix Proteins ◽  
Tumor Stroma ◽  
Mammary Tumors ◽  
Matrix Proteins ◽  
Metastatic Tumors ◽  
Tenascin C

The local growth of tumors and their ability to metastasize are crucially dependent on their interactions with the surrounding extracellular matrix. Tenascin-C (TNC) is an extracellular matrix protein which is highly expressed during development, tissue repair and cancer. Despite the high levels of TNC in the stroma of primary and metastatic tumors, the function of TNC is not known. In the present study we have crossed TNC-null mice with a mouse strain where both female and male mice spontaneously develop mammary tumors followed by metastatic disease in the lungs. We report that the absence of TNC had no effect on the temporal occurrence of mammary tumors and their metastatic dissemination in lungs. Furthermore, the number and size of tumors, the number and size of metastatic foci in the lungs, the proliferation rate and apoptosis of tumor cells and tumor angiogenesis were not altered in the absence of TNC. Histological examination revealed that the tumor organisation, however, was modulated by TNC. In the presence of TNC both primary as well as metastatic tumors were organised in large tumor cell nests surrounded by thick layers of extracellular matrix proteins. In the absence of TNC these tumor cell nests were smaller but still separated from each other by extracellular matrix proteins. In addition, the TNC-null stromal compartment contained significantly more monocytes/macrophages than tumor stroma from TNC wild-type mice. Using in vitro coculture experiments we show that TNC-null tumor cells were still able to activate the TNC gene in fibroblasts which express low basal levels of TNC. Altogether these data indicate that TNC has a very limited role during the spontaneous development and growth of mamary tumors and their metastasis to the lungs.

scholarly journals Alternative Splicing in the Aggrecan G3 Domain Influences Binding Interactions with Tenascin-C and Other Extracellular Matrix Proteins

2004 ◽  
Vol 279 (13) ◽  
pp. 12511-12518 ◽  
Author(s):  
Joanna M. Day ◽  
Anders I. Olin ◽  
Alan D. Murdoch ◽  
Ann Canfield ◽  
Takako Sasaki ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Alternative Splicing ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Binding Interactions ◽  
Tenascin C

scholarly journals Lung fibrotic tenascin-C upregulation is associated with other extracellular matrix proteins and induced by TGFβ1

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Susanna Estany ◽  
Vanesa Vicens-Zygmunt ◽  
Roger Llatjós ◽  
Ana Montes ◽  
Rosa Penín ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Tenascin C

scholarly journals Increased Obesity-Associated Circulating Levels of the Extracellular Matrix Proteins Osteopontin, Chitinase-3 Like-1 and Tenascin C Are Associated with Colon Cancer

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0162189 ◽  
Author(s):  
Victoria Catalán ◽  
Javier Gómez-Ambrosi ◽  
Amaia Rodríguez ◽  
Beatriz Ramírez ◽  
Maitane Izaguirre ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Extracellular Matrix ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Tenascin C ◽  
Circulating Levels

scholarly journals Dynamics of extracellular matrix proteins in cerebrospinal fluid and serum and their relation to clinical outcome in human traumatic brain injury

2019 ◽  
Vol 57 (10) ◽  
pp. 1565-1573 ◽  
Author(s):  
Karolina Minta ◽  
Nicholas C. Cullen ◽  
Faiez Al Nimer ◽  
Eric P. Thelin ◽  
Fredrik Piehl ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Extracellular Matrix ◽  
Cerebrospinal Fluid ◽  
Brain Injury ◽  
Clinical Outcome ◽  
Extracellular Matrix Proteins ◽  
Normal Pressure ◽  
Matrix Proteins ◽  
Healthy Controls ◽  
Tenascin C

Abstract Background Brevican, neurocan, tenascin-C and tenascin-R are extracellular matrix proteins present in brain that show increased expression in experimental animal models of brain injury. However, little is known about the dynamics of these proteins in human body fluids, such as cerebrospinal fluid (CSF) and serum, after traumatic brain injury (TBI). The aims of this study were to investigate if matrix proteins in CSF and serum are associated with functional outcome following traumatic brain injury, if their concentrations change over time and to compare their levels between brain injured patients to controls. Methods In total, 42 traumatic brain injury patients, nine healthy controls and a contrast group consisting of 38 idiopathic normal pressure hydrocephalus patients were included. Enzyme-linked immunosorbent assays (ELISAs) were used to measure the concentrations of proteins. Results Increased concentrations of brevican, tenascin-C and tenascin-R in CSF correlated with unfavourable outcome, with stronger outcome prediction ability compared to other biomarkers of brain tissue injury. CSF brevican, tenascin-R and serum neurocan gradually decreased with time (p = 0.04, p = 0.008, p = 0.005, respectively), while serum tenascin-C (p = 0.01) increased. CSF concentrations of brevican, neurocan and tenascin-R (only in time point 3) after TBI were lower than in the idiopathic normal pressure hydrocephalus group (p < 0.0001, p < 0.0001, and p = 0.0008, respectively). In serum, tenascin-C concentration was higher and neurocan lower compared to healthy controls (p = 0.02 and p = 0.0009). Conclusions These findings indicate that levels of extracellular matrix proteins are associated with clinical outcome following TBI and may act as markers for different pathophysiology than currently used protein biomarkers.

scholarly journals Early remodelling of the extracellular matrix proteins tenascin-C and phosphacan in retina and optic nerve of an experimental autoimmune glaucoma model

2016 ◽  
Vol 20 (11) ◽  
pp. 2122-2137 ◽  
Author(s):  
Sabrina Reinehr ◽  
Jacqueline Reinhard ◽  
Susanne Wiemann ◽  
Gesa Stute ◽  
Sandra Kuehn ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Optic Nerve ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Tenascin C ◽  
Experimental Autoimmune

Extracellular matrix proteins control the growth of cerebellar medulloblastoma cells

2004 ◽  
Vol 216 (03) ◽  
Author(s):  
U Schüller ◽  
W Hartmann ◽  
A Koch ◽  
K Schilling ◽  
OD Wiestler ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Cerebellar Medulloblastoma
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