Faculty Opinions recommendation of Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins.

2018 ◽  
Author(s):  
Giulio Gabbiani
Keyword(s):  
Extracellular Matrix ◽  
Trypanosoma Cruzi ◽  
Cardiac Fibroblasts ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins

scholarly journals Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Laura Lacerda Coelho ◽  
Isabela Resende Pereira ◽  
Mirian Claudia de Souza Pereira ◽  
Liliane Mesquita ◽  
Joseli Lannes-Vieira ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Trypanosoma Cruzi ◽  
Cardiac Fibroblasts ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins

In vitro evaluation of antagonism, modulation of cytokines and extracellular matrix proteins by Bifidobacterium strains

2018 ◽  
Vol 67 (5) ◽  
pp. 497-505 ◽  
Author(s):  
A.K.S. Silva ◽  
T.R.N. Silva ◽  
J.R. Nicoli ◽  
L.M.C. Vasquez-Pinto ◽  
F.S. Martins
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
In Vitro Evaluation

Effect of extracellular matrix proteins on in vitro testosterone production by rat Leydig cells

2002 ◽  
Vol 61 (4) ◽  
pp. 493-503 ◽  
Author(s):  
Emilce S. Diaz ◽  
Eliana Pellizzari ◽  
Silvina Meroni ◽  
Selva Cigorraga ◽  
Livia Lustig ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Leydig Cells ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Testosterone Production

scholarly journals High-Density Lipoproteins Limit Neutrophil-Induced Damage to the Blood–Brain Barrier in Vitro

2013 ◽  
Vol 33 (4) ◽  
pp. 575-582 ◽  
Author(s):  
Quoc Bao Dang ◽  
Bertrand Lapergue ◽  
Alexy Tran-Dinh ◽  
Devy Diallo ◽  
Juan-Antonio Moreno ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Blood Brain Barrier ◽  
Extracellular Matrix Proteins ◽  
High Density ◽  
Matrix Proteins ◽  
Brain Barrier ◽  
High Density Lipoproteins ◽  
Blood Brain

Breakdown of the blood–brain barrier (BBB) is a key step associated with ischemic stroke and its increased permeability causes extravasation of plasma proteins and circulating leukocytes. Polymorphonuclear neutrophil (PMN) proteases may participate in BBB breakdown. We investigated the role of PMNs in ischemic conditions by testing their effects on a model of BBB in vitro, under oxygen-glucose deprivation (OGD) to mimic ischemia, supplemented or not with high-density lipoproteins (HDLs) to assess their potential protective effects. Human cerebral endothelial cells cultured on transwells were incubated for 4 hours under OGD conditions with or without PMNs and supplemented or not with HDLs or alpha-1 antitrypsin (AAT, an elastase inhibitor). The integrity of the BBB was then assessed and the effect of HDLs on PMN-induced proteolysis of extracellular matrix proteins was evaluated. The release of myeloperoxidase and matrix metalloproteinase 9 (MMP-9) by PMNs was quantified. Polymorphonuclear neutrophils significantly increased BBB permeability under OGD conditions via proteolysis of extracellular matrix proteins. This was associated with PMN degranulation. Addition of HDLs or AAT limited the proteolysis and associated increased permeability by inhibiting PMN activation. Our results suggest a deleterious, elastase-mediated role of activated PMNs under OGD conditions leading to BBB disruption that could be inhibited by HDLs.

scholarly journals A7 COMP MUTATIONS AFFECT EXPRESSION PATTERNS OF EXTRACELLULAR MATRIX PROTEINS DURING IN VITRO CHONDROGENESIS

2006 ◽  
Vol 14 ◽  
pp. S20
Author(s):  
J.A. Roman-Blas ◽  
R.M. Seghatoleslami ◽  
A.S. Dion ◽  
K. van de Loo ◽  
P. Oca ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Expression Patterns ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Affect Expression
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