4,4-Dimethyl- and Diastereomeric 4-Hydroxy-4-methyl- (2S)-Glutamate Analogues Display Distinct Pharmacological Profiles at Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters

ChemMedChem ◽  
2009 ◽  
Vol 4 (11) ◽  
pp. 1925-1929 ◽  
Author(s):  
Lennart Bunch ◽  
Darryl S. Pickering ◽  
Thierry Gefflaut ◽  
Virginie Vinatier ◽  
Virgil Helaine ◽  
...  
Keyword(s):  
Amino Acid ◽  
Glutamate Receptors ◽  
Excitatory Amino Acid ◽  
Ionotropic Glutamate Receptors ◽  
Amino Acid Transporters ◽  
Excitatory Amino Acid Transporters ◽  
Glutamate Analogues ◽  
Pharmacological Profiles

scholarly journals Design and Synthesis of 2,3-trans-Proline Analogues as Ligands for Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters

2019 ◽  
Vol 10 (6) ◽  
pp. 2989-3007 ◽  
Author(s):  
Christian B. M. Poulie ◽  
Anna Alcaide ◽  
Mikkel Krell-Jørgensen ◽  
Younes Larsen ◽  
Eloi Astier ◽  
...  
Keyword(s):  
Amino Acid ◽  
Glutamate Receptors ◽  
Excitatory Amino Acid ◽  
Ionotropic Glutamate Receptors ◽  
Amino Acid Transporters ◽  
Excitatory Amino Acid Transporters ◽  
Design And Synthesis

Progressive Parkinsonism by acute dysfunction of excitatory amino acid transporters in the rat substantia nigra

2014 ◽  
Vol 65 ◽  
pp. 69-81 ◽  
Author(s):  
Maxime Assous ◽  
Laurence Had-Aissouni ◽  
Paolo Gubellini ◽  
Christophe Melon ◽  
Imane Nafia ◽  
...  
Keyword(s):  
Amino Acid ◽  
Substantia Nigra ◽  
Excitatory Amino Acid ◽  
Amino Acid Transporters ◽  
Excitatory Amino Acid Transporters ◽  
Rat Substantia Nigra

scholarly journals Recent Advance in the Relationship between Excitatory Amino Acid Transporters and Parkinson’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Yunlong Zhang ◽  
Feng Tan ◽  
Pingyi Xu ◽  
Shaogang Qu
Keyword(s):  
Parkinson’S Disease ◽  
Amino Acid ◽  
Animal Models ◽  
Substantia Nigra ◽  
Excitatory Amino Acid ◽  
Synaptic Cleft ◽  
Dopamine Neurons ◽  
Amino Acid Transporters ◽  
Excitatory Amino Acid Transporters ◽  
And Function

Parkinson’s disease (PD) is the most common movement disorder disease in the elderly and is characterized by degeneration of dopamine neurons and formation of Lewy bodies. Glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). If glutamate is not removed promptly in the synaptic cleft, it will excessively stimulate the glutamate receptors and induce excitotoxic effects on the CNS. With lack of extracellular enzyme to decompose glutamate, glutamate uptake in the synaptic cleft is mainly achieved by the excitatory amino acid transporters (EAATs, also known as high-affinity glutamate transporters). Current studies have confirmed that decreased expression and function of EAATs appear in PD animal models. Moreover, single unilateral administration of EAATs inhibitor in the substantia nigra mimics several PD features and this is a solid evidence supporting that decreased EAATs contribute to the process of PD. Drugs or treatments promoting the expression and function of EAATs are shown to attenuate dopamine neurons death in the substantia nigra and striatum, ameliorate the behavior disorder, and improve cognitive abilities in PD animal models. EAATs are potential effective drug targets in treatment of PD and thus study of relationship between EAATs and PD has predominant medical significance currently.

scholarly journals Klotho Sensitivity of the Neuronal Excitatory Amino Acid Transporters EAAT3 and EAAT4

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e70988 ◽  
Author(s):  
Ahmad Almilaji ◽  
Carlos Munoz ◽  
Tatsiana Pakladok ◽  
Ioana Alesutan ◽  
Martina Feger ◽  
...  
Keyword(s):  
Amino Acid ◽  
Excitatory Amino Acid ◽  
Amino Acid Transporters ◽  
Excitatory Amino Acid Transporters
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