Monoamine Oxidase (MAO) Inhibitory Activity: 3-Phenylcoumarins versus 4-Hydroxy-3-phenylcoumarins

ChemMedChem ◽  
2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Giovanna L. Delogu ◽  
Silvia Serra ◽  
Elias Quezada ◽  
Eugenio Uriarte ◽  
Santiago Vilar ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Inhibitory Activity

Synthesis and Evaluation of 2-benzylidene-1-tetralone Derivatives for Monoamine Oxidase Inhibitory Activity

2018 ◽  
Vol 18 (2) ◽  
pp. 136-149 ◽  
Author(s):  
Klaudia T. Amakali ◽  
Lesetja J. Legoabe ◽  
Anel Petzer ◽  
Jacobus P. Petzer
Keyword(s):  
Monoamine Oxidase ◽  
Inhibitory Activity

Monoamine oxidase inhibitory activity of someHypericumspecies native to South Brazil

2001 ◽  
Vol 53 (9) ◽  
pp. 1273-1279 ◽  
Author(s):  
Carmela Gnerre ◽  
Gilsane L. von Poser ◽  
Alexandre Ferraz ◽  
Alice Viana ◽  
Bernard Testa ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Inhibitory Activity ◽  
South Brazil

scholarly journals 8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects

2020 ◽  
Vol 56 ◽  
Author(s):  
María del Pilar Olaya ◽  
Nadezdha Esperanza Vergel ◽  
Jose Luis López ◽  
Dolores Viña ◽  
Mario Francisco Guerrero
Keyword(s):  
Monoamine Oxidase ◽  
Inhibitory Activity ◽  
Monoamine Oxidase B

scholarly journals Synthesis and evaluation of small molecules bearing a benzyloxy substituent as novel and potent monoamine oxidase inhibitors

MedChemComm ◽  
2017 ◽  
Vol 8 (2) ◽  
pp. 471-478 ◽  
Author(s):  
Jin-Shuai Lan ◽  
Tong Zhang ◽  
Yun Liu ◽  
Yong Zhang ◽  
Jian-wei Hou ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Small Molecules ◽  
Inhibitory Activity ◽  
Monoamine Oxidase Inhibitors

A new series of small molecules bearing a benzyloxy substituent have been designed, synthesized and evaluated for hMAO inhibitory activity in vitro.

scholarly journals Monoamine Oxidase Inhibitory Activity of Biflavonoids from Branches of Garcinia gardneriana (Clusiaceae)

2017 ◽  
Vol 12 (4) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Maria Angélica Recalde-Gil ◽  
Luiz Carlos Klein-Júnior ◽  
Carolina dos Santos Passos ◽  
Juliana Salton ◽  
Sérgio Augusto de Loreto Bordignon ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Inhibitory Activity ◽  
Ethanol Extract ◽  
Ethyl Acetate Fraction ◽  
Spectrometric Data ◽  
Mao B ◽  
Inhibitory Compounds ◽  
Mao A ◽  
Mao Activity

Garcinia gardneriana is chemically characterized by the presence of biflavonoids. Taking into account that flavonoids are able to inhibit monoamine oxidase (MAO) activity, in the present study, the chemical composition of the branches’ extract of the plant is described for the first time and the MAO inhibitory activity of the isolated biflavonoids was evaluated. Based on spectroscopic and spectrometric data, it was possible to identify volkesiflavone, morelloflavone (1), Gb-2a (2) and Gb-2a-7- O-glucoside (3) in the ethyl acetate fraction from ethanol extract of the branches. Compounds 1-3 were evaluated in vitro and demonstrated the capacity to inhibit MAO-A activity with an IC50 ranging from 5.05 to 10.7 μM, and from 20.7 to 66.2 μM for MAO-B. These inhibitions corroborate with previous IC50 obtained for monomeric flavonoids, with a higher selectivity for MAO-A isoform. The obtained results indicate that biflavonoids might be promising structures for the identification of new MAO inhibitory compounds.

Monoamine Oxidase Inhibitory Activity of Ferulic Acid Amides: Curcumin-Based Design and Synthesis

2015 ◽  
Vol 349 (1) ◽  
pp. 9-19 ◽  
Author(s):  
Vishnu N. Badavath ◽  
İpek Baysal ◽  
Gülberk Uçar ◽  
Susanta K. Mondal ◽  
Barij N. Sinha ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Ferulic Acid ◽  
Inhibitory Activity ◽  
Design And Synthesis

scholarly journals Coumarin analogue 3-methyl-7H-furo[3,2-g] chromen-7-one as a possible antiparkinsonian agent

Biomédica ◽  
2019 ◽  
Vol 39 (3) ◽  
pp. 491-501
Author(s):  
María del Pilar Olaya ◽  
Nadezdha Esperanza Vergel ◽  
José Luis López ◽  
María Dolores Viña ◽  
Mario Francisco Guerrero
Keyword(s):  
Antioxidant Activity ◽  
Monoamine Oxidase ◽  
Mouse Models ◽  
Inhibitory Activity ◽  
Ex Vivo ◽  
Monoamine Oxidase B ◽  
Mao B ◽  
Continue Research ◽  
Substituted Coumarins

Introduction: Parkinson’s disease is the second most common neurodegenerative disease. Monoamine oxidase B inhibitors are used in the treatment of this disease concomitantly with levodopa or as monotherapy. Several substituted coumarins have shown activity as inhibitors of monoamine oxidase B.Objective: To evaluate the possible antiparkinsonian effects of the coumarin analogue FCS005 (3-methyl-7H-furo[3,2-g]chromen-7-one) in mouse models, as well as its inhibitory activity towards monoamine oxidases (MAO) and its antioxidant activity.Materials and methods: FCS005 was synthesized and the reversal of hypokinesia was evaluated in the reserpine and levodopa models. Moreover, in the haloperidol model, its anticataleptic effects were evaluated. Additionally, the monoamine oxidase inhibitory activity and antioxidant activity of FCS005 were evaluated using in vitro and ex vivo studies, respectively.Results: FCS005 (100 mg/kg) caused the reversal of hypokinesia in the reserpine and levodopa models. This furocoumarin also presented anti-cataleptic effects at the same dose. Besides, it showed selective inhibitory activity towards the MAO-B isoform and antioxidant activity.Conclusion: These results attribute interesting properties to the compound FCS005. It is important to continue research on this molecule considering that it could be a potential antiparkinsonian agent.

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