Antibacterial Small Molecules That Potently Inhibit Staphylococcus aureus Lipoteichoic Acid Biosynthesis

ChemMedChem ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. 1000-1004 ◽  
Author(s):  
George A. Naclerio ◽  
Caroline W. Karanja ◽  
Clement Opoku‐Temeng ◽  
Herman O. Sintim
Keyword(s):  
Staphylococcus Aureus ◽  
Small Molecules ◽  
Lipoteichoic Acid ◽  
Acid Biosynthesis

scholarly journals In Vitro Bactericidal Activities of Daptomycin against Staphylococcus aureus and Enterococcus faecalis Are Not Mediated by Inhibition of Lipoteichoic Acid Biosynthesis

2003 ◽  
Vol 47 (8) ◽  
pp. 2682-2684 ◽  
Author(s):  
Valerie Laganas ◽  
Jeffrey Alder ◽  
Jared A. Silverman
Keyword(s):  
Staphylococcus Aureus ◽  
Enterococcus Faecalis ◽  
Mechanism Of Action ◽  
Lipoteichoic Acid ◽  
Acid Synthesis ◽  
Enterococcus Hirae ◽  
Macromolecular Synthesis ◽  
Acid Biosynthesis ◽  
Bactericidal Activities

ABSTRACT Previous studies have suggested that lipoteichoic acid biosynthesis inhibition is the mechanism of action of daptomycin. In this investigation, daptomycin inhibited all macromolecular synthesis in Staphylococcus aureus, Enterococcus faecalis, and Enterococcus hirae without kinetic or dose specificity for lipoteichoic acid. Daptomycin remained bactericidal in the absence of ongoing lipoteichoic acid synthesis. Inhibition of lipoteichoic acid synthesis is apparently not the mechanism of action of daptomycin in these pathogens.

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