Spatial patterns of mammalian brain aging: Distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease

2003 ◽  
Vol 464 (3) ◽  
pp. 371-381 ◽  
Author(s):  
Xiaoning Bi ◽  
Elizabeth Head ◽  
Carl W. Cotman ◽  
Gary Lynch
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Spatial Patterns ◽  
Cathepsin D ◽  
Brain Aging ◽  
Immunoreactive Cell ◽  
Mammalian Brain ◽  
Dystrophic Dendrites

Longitudinal Changes in Individual BrainAGE in Healthy Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

GeroPsych ◽  
2012 ◽  
Vol 25 (4) ◽  
pp. 235-245 ◽  
Author(s):  
Katja Franke ◽  
Christian Gaser
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Healthy Aging ◽  
Brain Aging ◽  
Elderly Subjects ◽  
Additional Increase ◽  
Longitudinal Changes ◽  
Novel Method ◽  
The Brain

We recently proposed a novel method that aggregates the multidimensional aging pattern across the brain to a single value. This method proved to provide stable and reliable estimates of brain aging – even across different scanners. While investigating longitudinal changes in BrainAGE in about 400 elderly subjects, we discovered that patients with Alzheimer’s disease and subjects who had converted to AD within 3 years showed accelerated brain atrophy by +6 years at baseline. An additional increase in BrainAGE accumulated to a score of about +9 years during follow-up. Accelerated brain aging was related to prospective cognitive decline and disease severity. In conclusion, the BrainAGE framework indicates discrepancies in brain aging and could thus serve as an indicator for cognitive functioning in the future.

scholarly journals Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease

2019 ◽  
Vol 10 (2) ◽  
pp. 470 ◽  
Author(s):  
Ashok K. Shetty ◽  
Raghavendra Upadhya ◽  
Leelavathi N. Madhu ◽  
Maheedhar Kodali
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyotrophic Lateral Sclerosis ◽  
Brain Aging ◽  
Lateral Sclerosis

scholarly journals Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer's disease

2018 ◽  
Vol 527 (13) ◽  
pp. 2122-2145 ◽  
Author(s):  
Jennifer D. Whitesell ◽  
Alex R. Buckley ◽  
Joseph E. Knox ◽  
Leonard Kuan ◽  
Nile Graddis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Imaging ◽  
Mouse Models ◽  
Spatial Patterns ◽  
Amyloid Beta ◽  
Whole Brain

scholarly journals Microglial dysfunction in brain aging and Alzheimer's disease

2014 ◽  
Vol 88 (4) ◽  
pp. 594-604 ◽  
Author(s):  
Kira Irving Mosher ◽  
Tony Wyss-Coray
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Aging

Lipidomics of Human Brain Aging and Alzheimer's Disease Pathology

2015 ◽  
pp. 133-189 ◽  
Author(s):  
Alba Naudí ◽  
Rosanna Cabré ◽  
Mariona Jové ◽  
Victoria Ayala ◽  
Hugo Gonzalo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Human Brain ◽  
Brain Aging
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