Hair cell innervation by spiral ganglion neurons in the mouse

1987 ◽  
Vol 255 (4) ◽  
pp. 560-570 ◽  
Author(s):  
A. M. Berglund ◽  
D. K. Ryugo
Keyword(s):  
Hair Cell ◽  
Spiral Ganglion ◽  
Spiral Ganglion Neurons ◽  
Hair Cell Innervation ◽  
Ganglion Neurons

scholarly journals Pou4f1 Defines a Subgroup of Type I Spiral Ganglion Neurons and Is Necessary for Normal Inner Hair Cell Presynaptic Ca2+ Signaling

2019 ◽  
Vol 39 (27) ◽  
pp. 5284-5298 ◽  
Author(s):  
Hanna E. Sherrill ◽  
Philippe Jean ◽  
Elizabeth C. Driver ◽  
Tessa R. Sanders ◽  
Tracy S. Fitzgerald ◽  
...  
Keyword(s):  
Hair Cell ◽  
Spiral Ganglion ◽  
Spiral Ganglion Neurons ◽  
Type I ◽  
Inner Hair Cell ◽  
Ganglion Neurons

scholarly journals Prickle1 regulates neurite outgrowth of apical spiral ganglion neurons but not hair cell polarity in the murine cochlea

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0183773 ◽  
Author(s):  
Tian Yang ◽  
Jennifer Kersigo ◽  
Shu Wu ◽  
Bernd Fritzsch ◽  
Alexander G. Bassuk
Keyword(s):  
Hair Cell ◽  
Neurite Outgrowth ◽  
Cell Polarity ◽  
Spiral Ganglion ◽  
Spiral Ganglion Neurons ◽  
Ganglion Neurons

scholarly journals Renewed proliferation in adult mouse cochlea and regeneration of hair cells

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Yilai Shu ◽  
Wenyan Li ◽  
Mingqian Huang ◽  
Yi-Zhou Quan ◽  
Deborah Scheffer ◽  
...  
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Adult Mouse ◽  
Spiral Ganglion ◽  
Cell Types ◽  
Spiral Ganglion Neurons ◽  
Supporting Cells ◽  
Styryl Dye ◽  
Co Activation ◽  
Ganglion Neurons

AbstractThe adult mammalian inner ear lacks the capacity to divide or regenerate. Damage to inner ear generally leads to permanent hearing loss in humans. Here, we present that reprogramming of the adult inner ear induces renewed proliferation and regeneration of inner ear cell types. Co-activation of cell cycle activator Myc and inner ear progenitor gene Notch1 induces robust proliferation of diverse adult cochlear sensory epithelial cell types. Transient MYC and NOTCH activities enable adult supporting cells to respond to transcription factor Atoh1 and efficiently transdifferentiate into hair cell-like cells. Furthermore, we uncover that mTOR pathway participates in MYC/NOTCH-mediated proliferation and regeneration. These regenerated hair cell-like cells take up the styryl dye FM1-43 and are likely to form connections with adult spiral ganglion neurons, supporting that Myc and Notch1 co-activation is sufficient to reprogram fully mature supporting cells to proliferate and regenerate hair cell-like cells in adult mammalian auditory organs.

scholarly journals Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Thomas M Coate ◽  
Nathalie A Spita ◽  
Kaidi D Zhang ◽  
Kevin T Isgrig ◽  
Matthew W Kelley
Keyword(s):  
Spiral Ganglion ◽  
Time Lapse ◽  
Spiral Ganglion Neurons ◽  
Type I ◽  
Inner Hair Cell ◽  
Semaphorin 3F ◽  
Innervation Patterns ◽  
Hair Cell Innervation ◽  
Mechanosensory Hair Cells ◽  
Ganglion Neurons

Auditory function is dependent on the formation of specific innervation patterns between mechanosensory hair cells (HCs) and afferent spiral ganglion neurons (SGNs). In particular, type I SGNs must precisely connect with inner HCs (IHCs) while avoiding connections with nearby outer HCs (OHCs). The factors that mediate these patterning events are largely unknown. Using sparse-labeling and time-lapse imaging, we visualized for the first time the behaviors of developing SGNs including active retraction of processes from OHCs, suggesting that some type I SGNs contact OHCs before forming synapses with IHCs. In addition, we demonstrate that expression of Semaphorin-3F in the OHC region inhibits type I SGN process extension by activating Neuropilin-2 receptors expressed on SGNs. These results suggest a model in which cochlear innervation patterns by type I SGNs are determined, at least in part, through a Semaphorin-3F-mediated inhibitory signal that impedes processes from extending beyond the IHC region.

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