Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus

1994 ◽  
Vol 340 (4) ◽  
pp. 551-565 ◽  
Author(s):  
Elizabeth Gould ◽  
Heather A. Cameron ◽  
Bruce S. McEwen
Keyword(s):  
Cell Death ◽  
Dentate Gyrus ◽  
Nmda Receptors ◽  
Developing Rat

scholarly journals The maintenance of specific aspects of neuronal function and behavior is dependent on programmed cell death of adult-generated neurons in the dentate gyrus

2009 ◽  
Vol 29 (7) ◽  
pp. 1408-1421 ◽  
Author(s):  
Woon Ryoung Kim ◽  
Ok-hee Park ◽  
Sukwoo Choi ◽  
Se-Young Choi ◽  
Soon Kwon Park ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Dentate Gyrus ◽  
Neuronal Function ◽  
And Behavior

scholarly journals Hippocampal distribution of IL-1β and IL-1RI following lithium-pilocarpine-induced status epilepticus in the developing rat

2016 ◽  
Vol 88 (suppl 1) ◽  
pp. 653-663 ◽  
Author(s):  
Dulce-Mariely Álvarez-Croda ◽  
Juan Santiago-García ◽  
Jesús S. Medel-Matus ◽  
Joel Martínez-Quiroz ◽  
Angel A. Puig-Lagunes ◽  
...  
Keyword(s):  
Cell Death ◽  
Status Epilepticus ◽  
Mrna Expression ◽  
Dorsal Hippocampus ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Control Group ◽  
Rat Pups ◽  
Fluoro Jade B ◽  
Developing Rat

The contribution of Interleukin-1β (IL-1β) to neuronal injury induced by status epilepticus (SE) in the immature brain remains unclear. The goal of this study was to determine the hippocampal expression of IL-1β and its type 1 receptor (IL-1RI) following SE induced by the lithium-pilocarpine model in fourteen-days-old rat pups; control animals were given an equal volume of saline instead of the convulsant. IL-1β and IL-1RI mRNA hippocampal levels were assessed by qRT-PCR 6 and 24 h after SE or control conditions. IL-1β and IL-1RI expression was detected in the dorsal hippocampus by immunohistochemical procedures; Fluoro-Jade B staining was carried out in parallel sections in order to detect neuronal cell death. IL-1β mRNA expression was increased 6 h following SE, but not at 24 h; however IL-1RI mRNA expression was unaffected when comparing with the control group. IL-1β and IL-1RI immunoreactivity was not detected in control animals. IL-1β and IL-1RI were expressed in the CA1 pyramidal layer, the dentate gyrus granular layer and the hilus 6 h after SE, whereas injured cells were detected 24 h following seizures. Early expression of IL-1β and IL-1RI in the hippocampus could be associated with SE-induced neuronal cell death mechanisms in the developing rat.

Mechanisms of ammonia-induced cell death in rat cortical neurons: Roles of NMDA receptors and glutathione

2005 ◽  
Vol 47 (1-2) ◽  
pp. 51-57 ◽  
Author(s):  
A KLEJMAN ◽  
M WEGRZYNOWICZ ◽  
E SZATMARI ◽  
B MIODUSZEWSKA ◽  
M HETMAN ◽  
...  
Keyword(s):  
Cell Death ◽  
Nmda Receptors ◽  
Cortical Neurons ◽  
Rat Cortical Neurons

scholarly journals NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death

2006 ◽  
Vol 103 (45) ◽  
pp. 16971-16976 ◽  
Author(s):  
J. C. de Rivero Vaccari ◽  
G. P. Casey ◽  
S. Aleem ◽  
W.-M. Park ◽  
R. A. Corriveau
Keyword(s):  
Cell Death ◽  
Nmda Receptors ◽  
Developmental Cell Death

Glutamate-induced cobalt uptake reveals non-NMDA receptors in developing rat taste buds

Neuroreport ◽  
2001 ◽  
Vol 12 (8) ◽  
pp. 1715-1718 ◽  
Author(s):  
Kyung-Nyun Kim ◽  
Alejandro Caicedo ◽  
Stephen D. Roper
Keyword(s):  
Nmda Receptors ◽  
Taste Buds ◽  
Cobalt Uptake ◽  
Developing Rat

Delayed Synaptogenesis in the Dentate Gyrus of the Thyroid-Deficient Developing Rat

1990 ◽  
Vol 12 (6) ◽  
pp. 398-405 ◽  
Author(s):  
Abdelhaq Rami ◽  
Alain Rabié
Keyword(s):  
Dentate Gyrus ◽  
Developing Rat
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