Cyclen-Based Cationic Lipids Containing Carbamate Linkages as Efficient Gene Delivery Vectors with Low Toxicity

ChemPlusChem ◽  
2012 ◽  
Vol 77 (7) ◽  
pp. 584-591 ◽  
Author(s):  
Qing-Dong Huang ◽  
Jiang Ren ◽  
Hong Chen ◽  
Wen-Jing Ou ◽  
Ji Zhang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cationic Lipids ◽  
Gene Delivery Vectors ◽  
Efficient Gene ◽  
Low Toxicity

scholarly journals Cyclen-Based Cationic Lipids for Highly Efficient Gene Delivery towards Tumor Cells

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e23134 ◽  
Author(s):  
Qing-Dong Huang ◽  
Guo-Xing Zhong ◽  
Yang Zhang ◽  
Jiang Ren ◽  
Yun Fu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Tumor Cells ◽  
Cationic Lipids ◽  
Highly Efficient ◽  
Efficient Gene

scholarly journals Cationic lipids with a cyclen headgroup: synthesis and structure–activity relationship studies as non-viral gene vectors

RSC Advances ◽  
2017 ◽  
Vol 7 (30) ◽  
pp. 18681-18689 ◽  
Author(s):  
De-Chun Chang ◽  
Yi-Mei Zhang ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
Xiao-Qi Yu
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Viral Gene ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Gene Delivery Vectors ◽  
Gene Vectors ◽  
Viral Gene Delivery

The structure–activity relationships of cyclen-based cationic lipids as non-viral gene delivery vectors were studied and clarified.

Cholesterol derived cationic lipids as potential non-viral gene delivery vectors and their serum compatibility

2016 ◽  
Vol 26 (10) ◽  
pp. 2401-2407 ◽  
Author(s):  
Jia Ju ◽  
Meng-Lei Huan ◽  
Ning Wan ◽  
Yi-Lin Hou ◽  
Xi-Xi Ma ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cationic Lipids ◽  
Viral Gene ◽  
Gene Delivery Vectors ◽  
Viral Gene Delivery

Biotinylated Cyclen-Contained Cationic Lipids as Non-Viral Gene Delivery Vectors

2013 ◽  
Vol 82 (4) ◽  
pp. 376-383 ◽  
Author(s):  
Qiang Liu ◽  
Wen-Jing Yi ◽  
Yi-Mei Zhang ◽  
Ji Zhang ◽  
Liandi Guo ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cationic Lipids ◽  
Viral Gene ◽  
Gene Delivery Vectors ◽  
Viral Gene Delivery

scholarly journals Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

2017 ◽  
Vol 53 (59) ◽  
pp. 8328-8331 ◽  
Author(s):  
Jamie C. Gaitor ◽  
Lauren M. Paul ◽  
Melissa M. Reardon ◽  
Taha Hmissa ◽  
Samuel Minkowicz ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Gene Delivery ◽  
Click Chemistry ◽  
Gene Transfection ◽  
Cationic Lipids ◽  
Efficient Gene

Novel lipidic ionic liquids with imidazolium headgroups (red), thioether linkers (black), and two hydrophobic tails (blue) as efficient gene transfection vectors, synthesized via thiol–yne click chemistry.

A carbon-based nanocarrier for efficient gene delivery

2021 ◽  
Author(s):  
Tahereh Kashkoulinejad-Kouhi ◽  
Shadi Sawalha ◽  
Shahrokh Safarian ◽  
Blanca Arnaiz
Keyword(s):  
Hydrogen Peroxide ◽  
Gene Delivery ◽  
Water Solubility ◽  
Chemotherapy Resistance ◽  
A549 Cells ◽  
Carbon Nanodots ◽  
Simple Method ◽  
Efficient Gene ◽  
Low Toxicity ◽  
Positively Charged

Aim: Several types of nanocarriers, most of which show significant cytotoxicity, have been developed to overcome the problem of gene-delivery barriers. Biocompatibility, low toxicity and water solubility of carbon nanodots (CNDs) are major advantages that recommend them as delivery systems. Materials & methods: We present a simple method to produce positively charged CNDs. Ethanolamine, ethylenediamine and hydrogen peroxide were utilized to synthesize these CNDs. Results & conclusion: Our results indicated that delivery of the CND–siGFP complex led to significant switching-off of the fluorescence of the GFP-expressing A549 cell. Next, the A549 cells were transfected with siRNA against BiP, which is a pivotal protein in the chemotherapy resistance of cancer cells. The expression levels of BiP decreased remarkably.

Cyclen-based cationic lipids containing a pH-sensitive moiety as gene delivery vectors

2015 ◽  
Vol 13 (2) ◽  
pp. 620-630 ◽  
Author(s):  
Zheng Huang ◽  
Yan-Hong Liu ◽  
Yi-Mei Zhang ◽  
Ji Zhang ◽  
Qiang Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Ph Sensitive ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Structure Activity ◽  
Gene Delivery Vectors

Imidazole-functionalized cationic lipids with a cyclen headgroup were synthesized, and the structure–activity relationship in gene delivery mediated by these lipids was discussed.

scholarly journals Biocleavable Polycationic Micelles as Highly Efficient Gene Delivery Vectors

2010 ◽  
Vol 5 (11) ◽  
pp. 1804-1811 ◽  
Author(s):  
Min Zhang ◽  
Ya-Nan Xue ◽  
Min Liu ◽  
Ren-Xi Zhuo ◽  
Shi-Wen Huang
Keyword(s):  
Gene Delivery ◽  
Highly Efficient ◽  
Gene Delivery Vectors ◽  
Efficient Gene

Engineered PEI-piperazinyl nanoparticles as efficient gene delivery vectors: evidence from both in vitro and in vivo studies

RSC Advances ◽  
2012 ◽  
Vol 2 (10) ◽  
pp. 4335 ◽  
Author(s):  
Soma Patnaik ◽  
Ritu Goyal ◽  
Sushil K. Tripathi ◽  
Mohammed Arif ◽  
Kailash C. Gupta
Keyword(s):  
Gene Delivery ◽  
In Vivo Studies ◽  
Gene Delivery Vectors ◽  
Efficient Gene
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