Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Volunteers Treated With GDC-0853, a Selective Reversible Bruton's Tyrosine Kinase Inhibitor

2018 ◽  
Vol 103 (6) ◽  
pp. 1020-1028 ◽  
Author(s):  
Ann E. Herman ◽  
Leslie W. Chinn ◽  
Shweta G. Kotwal ◽  
Elaine R. Murray ◽  
Rui Zhao ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Healthy Volunteers ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Bruton’S Tyrosine Kinase ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Bruton's Tyrosine Kinase

Separation of Bruton’s tyrosine kinase inhibitor atropisomers by supercritical fluid chromatography

2019 ◽  
Vol 1586 ◽  
pp. 106-115 ◽  
Author(s):  
Shiuhang Henry Yip ◽  
Dauh-Rurng Wu ◽  
Peng Li ◽  
Dawn Sun ◽  
Scott H. Watterson ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Kinase Inhibitor ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase

scholarly journals Development of an Efficient Manufacturing Process for Reversible Bruton’s Tyrosine Kinase Inhibitor GDC-0853

2018 ◽  
Vol 22 (8) ◽  
pp. 978-990 ◽  
Author(s):  
Haiming Zhang ◽  
Theresa Cravillion ◽  
Ngiap-Kie Lim ◽  
Qingping Tian ◽  
Danial Beaudry ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Manufacturing Process ◽  
Kinase Inhibitor ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase ◽  
Efficient Manufacturing

scholarly journals Long-term follow-up of patients with CLL treated with the selective Bruton’s tyrosine kinase inhibitor ONO/GS-4059

Blood ◽  
2017 ◽  
Vol 129 (20) ◽  
pp. 2808-2810 ◽  
Author(s):  
Harriet S. Walter ◽  
Sandrine Jayne ◽  
Simon A. Rule ◽  
Guillaume Cartron ◽  
Franck Morschhauser ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase ◽  
Long Term Follow Up
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