scholarly journals An activated‐zinc oral rinse reduces pro‐inflammatory cytokine secretion and promotes proliferation in Porphyromonas gingivalis LPS‐challenged gingival tissues – A pilot study

2021 ◽  
Author(s):  
Kaitlyn A. Stanton ◽  
Barbara A. McCracken
Keyword(s):  
Pilot Study ◽  
Porphyromonas Gingivalis ◽  
Inflammatory Cytokine ◽  
Cytokine Secretion ◽  
Oral Rinse ◽  
Porphyromonas Gingivalis Lps

Inhibition of Pro-Inflammatory Cytokine Secretion by Select Antioxidants in Human Coronary Artery Endothelial Cells

2020 ◽  
Vol 90 (1-2) ◽  
pp. 103-112 ◽  
Author(s):  
Michael J. Haas ◽  
Marilu Jurado-Flores ◽  
Ramadan Hammoud ◽  
Victoria Feng ◽  
Krista Gonzales ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Ascorbic Acid ◽  
Coronary Artery ◽  
Inflammatory Cytokines ◽  
Inflammatory Cytokine ◽  
Culture Media ◽  
Cytokine Secretion ◽  
Human Coronary Artery ◽  
Tnf Α ◽  
Pro Inflammatory Cytokines

Abstract. Inflammatory and oxidative stress in endothelial cells are implicated in the pathogenesis of premature atherosclerosis in diabetes. To determine whether high-dextrose concentrations induce the expression of pro-inflammatory cytokines, human coronary artery endothelial cells (HCAEC) were exposed to either 5.5 or 27.5 mM dextrose for 24-hours and interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor α (TNF α) levels were measured by enzyme immunoassays. To determine the effect of antioxidants on inflammatory cytokine secretion, cells were also treated with α-tocopherol, ascorbic acid, and the glutathione peroxidase mimetic ebselen. Only the concentration of IL-1β in culture media from cells exposed to 27.5 mM dextrose increased relative to cells maintained in 5.5 mM dextrose. Treatment with α-tocopherol (10, 100, and 1,000 μM) and ascorbic acid (15, 150, and 1,500 μM) at the same time that the dextrose was added reduced IL-1β, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1β, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose. However, ebselen treatment reduced IL-1β, IL-6, and IL-8 levels in cells maintained in either 5.5 or 27.5 mM dextrose. IL-2 and TNF α concentrations in culture media were below the limit of detection under all experimental conditions studied suggesting that these cells may not synthesize detectable quantities of these cytokines. These results suggest that dextrose at certain concentrations may increase IL-1β levels and that antioxidants have differential effects on suppressing the secretion of pro-inflammatory cytokines in HCAEC.

High Glucose Enhances Neurotoxicity and Inflammatory Cytokine Secretion by Stimulated Human Astrocytes

2017 ◽  
Vol 14 (7) ◽  
Author(s):  
Manpreet Bahniwal ◽  
Jonathan P. Little ◽  
Andis Klegeris
Keyword(s):  
High Glucose ◽  
Inflammatory Cytokine ◽  
Cytokine Secretion ◽  
Human Astrocytes

Human β‐defensin 3 binds to hemagglutinin B (rHagB), a non‐fimbrial adhesin from Porphyromonas gingivalis , and attenuates a pro‐inflammatory cytokine response

2008 ◽  
Vol 86 (8) ◽  
pp. 643-649 ◽  
Author(s):  
Lindsey C Pingel ◽  
Karl G Kohlgraf ◽  
Christopher J Hansen ◽  
Christopher G Eastman ◽  
Deborah E Dietrich ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Inflammatory Cytokine ◽  
Cytokine Response ◽  
Inflammatory Cytokine Response ◽  
Fimbrial Adhesin

109. Repeated social defeat increases cytokine production by Porphyromonas gingivalis LPS-stimulated macrophages

2008 ◽  
Vol 22 (4) ◽  
pp. 34-35
Author(s):  
Michael Bailey ◽  
Steven Kinsey ◽  
Rebecca Allen ◽  
David Padgett ◽  
John Sheridan
Keyword(s):  
Porphyromonas Gingivalis ◽  
Cytokine Production ◽  
Social Defeat ◽  
Porphyromonas Gingivalis Lps

Nobiletin reduces LPL-mediated lipid accumulation and pro-inflammatory cytokine secretion through upregulation of miR-590 expression

2019 ◽  
Vol 508 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Ping-Ping He ◽  
Qian-Qian Shen ◽  
Min Wen ◽  
Jie-Qiong Zou ◽  
Yan Wang ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Inflammatory Cytokine ◽  
Cytokine Secretion

Endotoxin recognition in fish results in inflammatory cytokine secretion not gene expression

2010 ◽  
Vol 17 (1) ◽  
pp. 16-28 ◽  
Author(s):  
Nerea Roher ◽  
Agnes Callol ◽  
Josep V. Planas ◽  
Frederick W. Goetz ◽  
Simon A. MacKenzie
Keyword(s):  
Gene Expression ◽  
Inflammatory Cytokine ◽  
Cytokine Secretion
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