scholarly journals Liquid‐based cell suspension of supraclavicular lymph node fine‐needle aspirate as an alternative specimen for NGS‐based genomic profiling in advanced lung cancer

2020 ◽  
Vol 10 (6) ◽  
Author(s):  
Xun Zhang ◽  
Ying Chen ◽  
Li Chu ◽  
Jianjiao Ni ◽  
Analyn Lizaso ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Cell Suspension ◽  
Advanced Lung Cancer ◽  
Genomic Profiling ◽  
Fine Needle Aspirate ◽  
Supraclavicular Lymph Node ◽  
Fine Needle ◽  
Alternative Specimen

Comprehensive genomic profiling of lung cancer cytologic specimens obtained by guided fine-needle aspirate biopsies.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e21002-e21002
Author(s):  
Sugganth Daniel ◽  
Laurie M. Gay ◽  
Siraj Mahamed Ali ◽  
Charlotte Brown ◽  
Shakti Ramkissoon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Genomic Profiling ◽  
Fine Needle Aspirate ◽  
Fine Needle ◽  
Comprehensive Genomic Profiling

scholarly journals Clinical Impact of Supraclavicular Lymph Node Involvement of Stage IIIC Non-Small Cell Lung Cancer Patients

Medicina ◽  
2021 ◽  
Vol 57 (3) ◽  
pp. 301
Author(s):  
Sunmin Park ◽  
Won Sup Yoon ◽  
Mi Hee Jang ◽  
Chai Hong Rim
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Small Cell Lung Cancer ◽  
Local Control ◽  
Small Cell ◽  
Clinical Impact ◽  
Small Cell Lung ◽  
Stage Iiic ◽  
Supraclavicular Lymph Node ◽  
Grade 3

Background and Objective: Investigations on the clinical impact of supraclavicular lymph node (SCN) involvement in stage IIIC non-small cell lung cancer (NSCLC) remain scarce. We evaluated the oncological outcomes of definitive radiochemotherapy and the clinical significance of SCN involvement. Materials and Methods: Between November 2009 and June 2019, a total of 40 patients with N3-positivity and NSCLC were evaluated. Most patients received concomitant chemotherapy, but six patients who received radiotherapy (RT) alone were also included. Twenty-one patients (52.5%) received 3D-conformal RT (3DCRT), and the remainder received intensity-modulated RT (IMRT). Results: The median follow-up duration was 10.7 months (range: 1.7–120.6 months). Median overall survival (OS) and cause-specific survival (CSS) times were 10.8 months and 16.3 months, respectively. Among the 40 patients, 17 (42.5%) had SCN involvement. SCN involvement negatively affected progression-free survival (hazard ratio (HR): 2.08, 95% confidence interval (CI): 1.04–4.17, p = 0.039) and local control (HR: 3.05, 95% CI: 1.09–8.50, p = 0.034). However, IMRT use was correlated with higher local control (HR: 0.28, 95% CI: 0.09–0.86, p = 0.027). Grade ≥3 esophagitis and pneumonitis accounted for 7.5% and 15.0% of all cases, respectively. A higher RT dose (mean dose: 66.6 vs. 61.7 Gy) was significantly correlated with grade ≥3 pneumonitis (p = 0.001). RT modality was a significant factor (p = 0.042, five of six cases occurred in the IMRT group). Conclusions: SCN involvement could negatively affect oncologic outcomes of stage IIIC NSCLC patients. High-dose irradiation with IMRT could increase local control but may cause lung toxicities.

scholarly journals Lymphogranuloma Venereum: a Croatian Case Report of a Patient with Proctitis and Concurrent Cervical Lymphadenitis

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S106-S106
Author(s):  
Branimir Gjurasin ◽  
Josip Begovac
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Cervical Lymph Node ◽  
Rectal Swab ◽  
Cervical Lymphadenopathy ◽  
Lymphogranuloma Venereum ◽  
Purulent Discharge ◽  
Fine Needle Aspirate ◽  
Cervical Lymphadenitis ◽  
Fine Needle

Abstract Background Lymphogranuloma venereum (LGV) can present with genital ulcers, proctitis, or femoral/inguinal lymphadenopathy with or without constitutional symptoms. There have been reports on the infection characterized by supraclavicular or cervical lymphadenopathy, although there is no published data on the detection of Chlamydia trachomatis (CT) in the affected lymph node. Methods We report a patient with pharyngitis, proctitis and cervical lymphadenitis, in whom LGV specific DNA was detected by polimerase chain reaction (PCR) in both the rectal swab and cervical lymph node fine needle aspirate. Results A 48-year-old Croatian HIV-positive male patient attended our outpatient HIV clinic complaining of a 10-day perianal pain, bloody rectal discharge with normal stool consistency and painful and enlarged cervical lymph node. On the first day he had fever, which subsided on the following day. Clinical examination demonstrated exudate on the right tonsil, painful, and enlarged right cervical lymph node (5 × 2 cm, Figure 1), perianal pain on palpation and rectal purulent discharge. During the preceding 10-year period, the patient was taking his antiretroviral therapy regularly and had an undetectable HIV RNA by PCR. We started treatment with ceftriaxone and doxycycline. The fine needle aspirate of the affected lymph node showed a pyogranulomatous inflammation. Indirect immunofluorescence assay on CT antibodies detected positive titers in IgG (>512) and IgA (256) classes. LGV-specific DNA was detected in both the rectal swab and the cervical lymph node fine needle aspirate. Ceftriaxone was discontinued after 5 days and doxycycline therapy was continued for a total of 6 weeks because of the persistence of the cervical lymphadenopathy. The patient came to a full recovery. Conclusion We found six published case reports on LGV with associated cervical lymphadenopathy in which the infection with CT was established by serologic testing and/or by nucleic acid amplification tests of the pharyngeal and/or rectal swabs. Some of the mentioned reports demonstrated granulomatous inflammation present in the affected cervical lymph node, as was evidenced in our patient. To our knowledge, this is the first case report of a patient with CT infection in whom LGV-specific DNA was detected in the cervical lymph node. Disclosures All authors: No reported disclosures.

Sign in / Sign up

Export Citation Format

Share Document