scholarly journals Detection and quantification of circulating tumor cells in mouse models of human breast cancer using immunomagnetic enrichment and multiparameter flow cytometry

2005 ◽  
Vol 65A (1) ◽  
pp. 4-14 ◽  
Author(s):  
Alison L. Allan ◽  
Sharon A. Vantyghem ◽  
Alan B. Tuck ◽  
Ann F. Chambers ◽  
Ian H. Chin-Yee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Flow Cytometry ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Mouse Models ◽  
Human Breast Cancer ◽  
Multiparameter Flow Cytometry ◽  
Human Breast ◽  
Immunomagnetic Enrichment ◽  
Detection And Quantification

Capture of Very Rare Circulating Tumor Cells for Human Breast Cancer Diagnosis

2007 ◽  
Author(s):  
Taehyun Park ◽  
Timothy Jensen ◽  
Daniel Park ◽  
Jason Guy ◽  
Proyag Datta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Diagnosis ◽  
Human Breast Cancer ◽  
Microfluidic Channel ◽  
Breast Cancer Diagnosis ◽  
Breast Cancer Cell Lines ◽  
Target Cells ◽  
Human Breast

A method of collecting and delivering single or precise numbers of cells to assess the feasibility of capturing very rare circulating tumor cells for human breast cancer diagnosis and monitoring was developed. A PMMA device was assembled with minimal assembly variation using passive alignment. Thermoplastic fusion bonding was optimized to yield minimal deformation of the microfluidic channel. UV modification and an anti-epithelial cell adhesion molecule (anti-EpCAM) functionalization process were used to generate capture surfaces and maximized by control experiment. Single or precise numbers of target cells were collected using a cell collecting capillary tube and a hemacytometer and delivered into the microchannel without any loss. Cells from one of the human breast cancer cell lines, the MCF-7 cell line (ATCC, Manassas, VA) which strongly overexpresses EpCAM, were successfully captured on the anti-EpCAM coated microchannel surfaces. Successful capture of early stage breast cancer cells in whole blood may be feasible with further optimization of the microchannel geometry and flow velocity through the microfluidic device.

scholarly journals MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer

2009 ◽  
Vol 9 (5) ◽  
pp. 423-440 ◽  
Author(s):  
Pankaj Taneja ◽  
Donna P Frazier ◽  
Robert D Kendig ◽  
Dejan Maglic ◽  
Takayuki Sugiyama ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mouse Models ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Diagnostic Values

Abstract 1400: Mouse models for detection of circulating tumor cells from breast cancer

2012 ◽  
Author(s):  
Arunasalam Navaraj ◽  
David T. Dicker ◽  
Wafik S. El-Deiry
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Mouse Models

Abstract 2978:In vivoprofiling of migratory tumor cells identifies novel mediators for invasion and dissemination in human breast cancer.

2012 ◽  
Author(s):  
Antonia Patsialou ◽  
Yarong Wang ◽  
Juan Lin ◽  
Kathleen Whitney ◽  
Sumanta Goswami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Human Breast Cancer ◽  
Human Breast

Serotonergic antagonists target breast tumor-initiating cells in mouse models of human breast cancer

2016 ◽  
Vol 69 ◽  
pp. S83
Author(s):  
W. Gwynne ◽  
R. Hallett ◽  
A. Girgis-Gabardo ◽  
A. Dvorkin-Gheva ◽  
J. Hassell
Keyword(s):  
Breast Cancer ◽  
Mouse Models ◽  
Breast Tumor ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Tumor Initiating Cells

scholarly journals Transfer of siRNA against XIAP induces apoptosis and reduces tumor cells growth potential in human breast cancer in vitro and in vivo

2007 ◽  
Vol 103 (1) ◽  
pp. 129-129
Author(s):  
Yingchao Zhang ◽  
Yu Wang ◽  
Wenxin Gao ◽  
Ruhui Zhang ◽  
Xichun Han ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Human Breast Cancer ◽  
Growth Potential ◽  
Human Breast
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