scholarly journals MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer

2009 ◽  
Vol 9 (5) ◽  
pp. 423-440 ◽  
Author(s):  
Pankaj Taneja ◽  
Donna P Frazier ◽  
Robert D Kendig ◽  
Dejan Maglic ◽  
Takayuki Sugiyama ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mouse Models ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Diagnostic Values

Serotonergic antagonists target breast tumor-initiating cells in mouse models of human breast cancer

2016 ◽  
Vol 69 ◽  
pp. S83
Author(s):  
W. Gwynne ◽  
R. Hallett ◽  
A. Girgis-Gabardo ◽  
A. Dvorkin-Gheva ◽  
J. Hassell
Keyword(s):  
Breast Cancer ◽  
Mouse Models ◽  
Breast Tumor ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Tumor Initiating Cells

scholarly journals Therapeutic Effects of Autologous Lymphocytes Activated with Trastuzumab for Xenograft Mouse Models of Human Breast Cancer

2013 ◽  
Vol 36 (5) ◽  
pp. 861-865
Author(s):  
Shinichiro Nakagawa ◽  
Yusuke Matsuoka ◽  
Hideaki Ichihara ◽  
Hitoji Yoshida ◽  
Kenshi Yoshida ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mouse Models ◽  
Human Breast Cancer ◽  
Therapeutic Effects ◽  
Human Breast

scholarly journals Integrated sequence and gene expression analysis of mouse models of breast cancer reveals critical events with human parallels

2018 ◽  
Author(s):  
Jonathan P Rennhack ◽  
Matthew Swiatnicki ◽  
Yueqi Zhang ◽  
Caralynn Li ◽  
Evan Bylett ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Cancer Patients ◽  
Mouse Models ◽  
Copy Number ◽  
Human Breast Cancer ◽  
Human Cancer ◽  
Copy Number Alterations ◽  
Human Breast ◽  
Lung Cancer Patients

AbstractMouse models have an essential role in cancer research, yet little is known about how various models resemble human cancer at a genomic level. However, the shared genomic alterations in each model and corresponding human cancer are critical for translating findings in mice to the clinic. We have completed whole genome sequencing and transcriptome profiling of two widely used mouse models of breast cancer, MMTV-Neu and MMTV-PyMT. This genomic information was integrated with phenotypic data and CRISPR/Cas9 studies to understand the impact of key events on tumor biology. Despite the engineered initiating transgenic event in these mouse models, they contain similar copy number alterations, single nucleotide variants, and translocation events as human breast cancer. Through integrative in vitro and in vivo studies, we identified copy number alterations in key extracellular matrix proteins including Collagen 1 Type 1 alpha 1 (Col1a1) and Chondroadherin (CHAD) that drive metastasis in these mouse models. Importantly this amplification is also found in 25% of HER2+ human breast cancer and is associated with increased metastasis. In addition to copy number alterations, we observed a propensity of the tumors to modulate tyrosine kinase mediated signaling through mutation of phosphatases. Specifically, we found that 81% of MMTV-PyMT tumors have a mutation in the EGFR regulatory phosphatase, PTPRH. Mutation in PTPRH led to increased phospho-EGFR levels and decreased latency. Moreover, PTPRH mutations increased response to EGFR kinase inhibitors. Analogous PTPRH mutations are present in lung cancer patients and together this data suggests that a previously unidentified population of human lung cancer patients may respond to EGFR targeted therapy. These findings underscore the importance of understanding the complete genomic landscape of a mouse model and illustrate the utility this has in understanding human cancers.

scholarly journals Integrin-mediated signal transduction in transgenic mouse models of human breast cancer

2003 ◽  
Vol 5 (S1) ◽  
Author(s):  
DE White ◽  
S Blaess ◽  
U Mueller ◽  
S Dedhar ◽  
RD Cardiff ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signal Transduction ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Human Breast Cancer ◽  
Transgenic Mouse Models ◽  
Human Breast
Sign in / Sign up

Export Citation Format

Share Document