Clear cell carcinoma first suspected in Pap smear. The value of neutrophil cannibalism by tumor cells

2016 ◽  
Vol 45 (2) ◽  
pp. 176-178 ◽  
Author(s):  
Badr AbdullGaffar
Keyword(s):  
Cell Carcinoma ◽  
Tumor Cells ◽  
Pap Smear ◽  
Clear Cell ◽  
Clear Cell Carcinoma

scholarly journals A Case of Hyalinizing Clear Cell Carcinoma, So-Called Clear Cell Carcinoma, Not Otherwise Specified, of the Minor Salivary Glands of the Buccal Mucosa

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Takahiro Yamanishi ◽  
Kiwako Kutsuma ◽  
Keisuke Masuyama
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Tumor Cells ◽  
Buccal Mucosa ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Glands ◽  
Hyalinizing Clear Cell Carcinoma ◽  
Not Otherwise Specified ◽  
The Right

Hyalinizing clear cell carcinoma (HCCC), so-called clear cell carcinoma, not otherwise specified (CCC (NOS)), of the salivary glands is a rare and low-grade malignant tumor. We report a case of HCCC so-called CCC (NOS) (referred to as HCCC) of the minor salivary gland of the buccal mucosa. A 52-year-old woman had presented with a gradually growing and indolent mass in the right buccal mucosa for about two years. The first biopsy histopathologically suggested the possibility of malignancy derived from the minor salivary glands. A month later, she visited our hospital. The tumor measured approximately 1.5 cm in diameter and was elastic hard, smooth, and well movable. Image examinations demonstrated internal homogeneity of the lesion, which had a smooth margin, in the right buccal mucosa. Complete tumor resection followed by covering with a polyglycolic acid sheet and fibrin glue spray was performed without surgical flap reconstruction. Histopathological findings revealed proliferating tumor cells with clear cytoplasm surrounded by hyalinizing stroma in the submucosal minor salivary glands. Immunohistochemical stains revealed these tumor cells to be positive for epithelial cell markers but negative for myoepithelial ones. These findings confirmed the diagnosis of HCCC. Good wound healing and no evidence of local recurrence and metastasis have been shown since surgery.

scholarly journals Ovarian Seromucinous Borderline Tumor and Clear Cell Carcinoma: An Unusual Combination

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Eriko Nakamura ◽  
Yuichiro Sato ◽  
Sayaka Moriguchi ◽  
Atsushi Yamashita ◽  
Takashi Higo ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Tumor Cells ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
English Literature ◽  
Borderline Tumor ◽  
Borderline Tumors ◽  
First Case ◽  
Napsin A ◽  
Unusual Combination

Ovarian seromucinous borderline tumors (SMBTs) are rare. They architecturally resemble serous borderline tumors but are much more frequently associated with endometriosis. The coexistence of other tumors with seromucinous tumors is also extremely rare. Here, we report an unusual combination of bilateral ovarian SMBT and clear cell carcinoma associated with polypoid endometriosis of the colon, in a 62-year-old woman. There was no transitional lesion between the two tumors. Immunohistochemistry showed different staining patterns in tumor components. Seromucinous tumor cells were positive for estrogen receptor (ER) and progesterone receptor (PgR) but negative for Napsin A, p504S, and HNF1B. Clear cell tumor cells were positive for Napsin A and p504S and focally positive for HNF1B but negative for ER and PgR. Loss of ARID1A expression was not observed in SMBTs, clear cell tumors, or endometriosis. These findings suggest that these tumors arose from separate endometriosis foci and collided within the same ovary. To the best of our knowledge, this is the first case of this unusual combination of ovarian seromucinous tumor and clear cell carcinoma to be reported in the English literature.

scholarly journals Clear Cell Carcinoma of Endometrium: A Clinical Review

2014 ◽  
Vol 2 (1) ◽  
pp. 15-19
Author(s):  
Rajani Rawat ◽  
Soniya Vishwakarma ◽  
Shikha Seth ◽  
Vaibhav Kanti ◽  
Pragati Mishra
Keyword(s):  
Endometrial Cancer ◽  
Cell Carcinoma ◽  
Clinical Review ◽  
Pap Smear ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Clinical Staging ◽  
Transvaginal Sonography ◽  
Histopathological Diagnosis ◽  
Management Protocol

ABSTRACT Clear cell carcinoma of endometrium is a rare (1-6%) but aggressive malignancy with high propensity of early extra-uterine spread. The usual presentation is postmenopausal bleeding and discharge as with other endometrial cancers but it does not have preceding hyperplastic stage, instead it develops from thin atrophic endometrium, therefore impossible to identify by the screening measures like Pap smear and transvaginal sonography. First step for early diagnosis of such unfavorable endometrial cancer should be endometrial biopsy. Histopathological diagnosis is mandatory to confirm the clear cells present in the endometrial sample before planning the management. Clinical staging is highly erroneous in clear cell endometrial cancer and should not be taken into consideration in management plan. Being a rare cancer, there is lack of true evidence on its management protocol. Here, we had tried to provide the review about the clear cell endometrial (CCE) cancer diagnosis and management along with a case report for clinical perspective. How to cite this article Seth S, Rawat R, Kanti V, Mishra P, Vishwakarma S. Clear Cell Carcinoma of Endometrium: A Clinical Review. J South Asian Feder Menopause Soc 2014;2(1):15-19.

scholarly journals Glycogen Rich Clear Cell Carcinoma Pada Payudara

2019 ◽  
Vol 6 (2) ◽  
pp. 146-149
Author(s):  
Finot Finot ◽  
Dik Puspasari ◽  
Siti Amarwati
Keyword(s):  
Breast Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Periodic Acid ◽  
Low Grade ◽  
Breast Cancers ◽  
Signet Ring ◽  
Pas Staining

Background: Glycogen rich clear cell carcinoma is a rare neoplasm of the breast, with the incidence of 1.4-3% of all breast cancers. The tumour has distinct morphology, different from that of common breast cancers. Glycogen rich clear cell carcinomas are members of a heterogeneous group of neoplasms, including signet-ring, secretory and lipid-rich carcinomas of the breast. In general, clear cell breast carcinoma tends to follow an aggressive clinical course. Case report: To present a case of a 47 years old woman suffering from breast mass in the upper outer quadrant of her right breast. On macroscopic examination, the biopsy tumor sized 2x1.5x0.5 cm and solid with brown and white. Discussion: Microscopic examination showed breast tissue composed of tumor cells arranged in nets, trabeculae and singly dispersed. Tumor cells are moderately pleomorphic, have sharply defined border and polygonal contours. Cytoplasm is clear in more than 90% of cells and finely granular in few cells. Nuclei are hyperchromatic with clumped chromatin and prominent nucleoli. Occasional mitosis is also observed. Special stain (PAS Staining): Intracytoplasmic PAS positivity in tumor cells are variable. Immunohistochemistry ER (+) positive >20-50%, PR (+) positive <20%, HER2 (-) negative. The patient was diagnosed with glycogen rich clear cell carcinoma. Conclusion: Glycogen rich clear cell carcinoma of the breast is rare. Its clinical feature is rather aggressive and varies depending on special characteristics such as low grade. Keywords: Glycogen rich clear cell carcinoma, breast carcinoma, PAS staining   Latar belakang: Glycogen rich clear cell carcinoma adalah kanker payudara yang jarang, dengan insidensi 1.4-3% dari semua kanker payudara. Tumor memiliki morfologi yang berbeda dari kanker payudara pada umunya. Glycogen rich clear cell carcinoma merupakan neoplasma heterogen yang termasuk karsinoma payudara signet-ring, sekretori dan kaya lipid. Secara umum, carcinoma ini cenderung mengikuti perjalanan klinis yang agresif. Tujuan: Laporan Kasus: Dilakukan pemeriksaan makroskopis jaringan tumor dari seorang perempuan berusia 47 tahun dengan massa payudara kanan di kuadran luar atas. Tumor biopsi berukuran 2x1.5x0.5 cm, komposisi padat, berwarna coklat dan putih. Dilakukan pemeriksaan histopatologi, imunohistokimia dan histokimia pewarnaan khusus PAS (Periodic Acid Schiff). Pembahasan: Pemeriksaan mikroskopis menunjukkan jaringan payudara dengan sel-sel tumor yang tersusun dalam jaring, trabekula dan tersebar tunggal. Sel-sel tumor cukup pleomorfik, hiperkromatik, kromatin kasar dan nucleoli prominent, mitosis dapat ditemukan, sitoplasma jernih lebih dari 90% sel dan granular halus dalam beberapa sel, memiliki garis batas dan beberapa bentuk poligon yang jelas. Hasil histokimia PAS (+) positif, Immunohistokimia ER (+) positif > 20-50% pada sel-sel tumor, PR (+) positif < 20%, HER2 (-) negatif. Dari hasil pemeriksaan tersebut, pasien didiagnosis Glycogen rich clear cell carcinoma. Kesimpulan: Glycogen rich clear cell carcinoma pada payudara adalah tumor yang jarang, perilaku klinisnya dilaporkan agak agresif sejauh ini, sangat bervariasi tergantung pada karakteristik khusus seperti tingkat rendah. Kata kunci: Glycogen rich clear cell carcinoma, karsinoma payudara, pewarnaan PAS.

scholarly journals A RARE CASE OF CLEAR CELL CARCINOMA OF ENDOMETRIUM IN A POST-MENOPAUSAL WOMAN- A HISTOPATHOLOGICAL CASE REPORT

2021 ◽  
pp. 10-11
Author(s):  
Joyeeta Mandal ◽  
Manoj Kumar Paswan ◽  
Arpana Shailaly Tirkey ◽  
Sona Pathak
Keyword(s):  
Cell Carcinoma ◽  
Vaginal Bleeding ◽  
Pap Smear ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Relevant Literature ◽  
Endometrial Biopsy ◽  
Menopausal Woman ◽  
Histopathological Diagnosis ◽  
Post Menopausal

Clear cell carcinoma of endometrium is a rare but aggressive malignancy with high predisposition of early extra-uterine spread. It commonly presents with vaginal bleeding or discharge. Less commonly, it may be diagnosed subsequent to an abnormal pap smear. Endometrial biopsy is ideally the first step for early diagnosis of such unfavourable endometrial cancer. Histopathological diagnosis is mandatory to confirm the presence of clear cells in the endometrial sample before planning the course of treatment. Here, we report a case of a postmenopausal woman who presented with vaginal bleeding without a specific medical history. Endometrial biopsy was done and sample was sent to our department of Pathology for histopathological diagnosis. We report the case from a histopathological perspective with a brief review of the relevant literature.

Diagnostic Impacts of Serum CA-125 Levels, Pap Smear Evaluation, and Endometrial Sampling in Women with Endometrial Clear Cell Carcinoma

2016 ◽  
Vol 39 (5) ◽  
pp. 283-288 ◽  
Author(s):  
Nilufer Cetinkaya ◽  
İlker Selcuk ◽  
Bulent Ozdal ◽  
Mehmet M. Meydanli ◽  
Tayfun Gungor
Keyword(s):  
Cell Carcinoma ◽  
Pap Smear ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Ca 125 ◽  
Endometrial Sampling

Delayed Pancreatic Metastasis of Renal Clear Cell Carcinoma

2013 ◽  
Vol 13 (2) ◽  
pp. 79-80
Author(s):  
Zane Simtniece ◽  
Gatis Kirsakmens ◽  
Ilze Strumfa ◽  
Andrejs Vanags ◽  
Maris Pavars ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Surgical Treatment ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Primary Tumour ◽  
Renal Clear Cell Carcinoma ◽  
Pancreatic Metastasis ◽  
Distal Pancreatic Resection

Abstract Here, we report surgical treatment of a patient presenting with pancreatic metastasis (MTS) of renal clear cell carcinoma (RCC) 11 years after nephrectomy. RCC is one of few cancers that metastasise in pancreas. Jaundice, abdominal pain or gastrointestinal bleeding can develop; however, asymptomatic MTS can be discovered by follow-up after removal of the primary tumour. The patient, 67-year-old female was radiologically diagnosed with a clinically silent mass in the pancreatic body and underwent distal pancreatic resection. The postoperative period was smooth. Four months after the surgery, there were no signs of disease progression.

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