Identification and characterization of urinary prenylamine metabolites by means of liquid chromatography-tandem mass spectrometry

2012 ◽  
Vol 4 (9) ◽  
pp. 701-716 ◽  
Author(s):  
S. Beuck ◽  
G. Sigmund ◽  
A. Koch ◽  
W. Schänzer ◽  
A. Pokrywka ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Identification And Characterization

Detection and characterization of ponatinib reactive metabolites by liquid chromatography tandem mass spectrometry and elucidation of bioactivation pathways

RSC Advances ◽  
2016 ◽  
Vol 6 (76) ◽  
pp. 72575-72585 ◽  
Author(s):  
Adnan A. Kadi ◽  
Hany W. Darwish ◽  
Mohamed W. Attwa ◽  
Sawsan M. Amer
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Reactive Metabolites ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Trapping Agent ◽  
Identification And Characterization

This study involved the identification and characterization of ponatinib by LC-MS/MS. Additionally ponatinib reactive metabolites were also investigated using KCN as a trapping agent, showing the formation of four reactive cyano adducts.

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