Identification and Characterization of Terpenoid Lactones and Flavonoids from Ethanolic Extract ofAndrographis Paniculata(Burm.f.) Nees Using Liquid Chromatography/Tandem Mass Spectrometry

2018 ◽  
Vol 1 (12) ◽  
pp. 762-770 ◽  
Author(s):  
Sunil Kumar ◽  
Awantika Singh ◽  
Vikas Bajpai ◽  
Kulwant R. Sharma ◽  
Brijesh Kumar
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Ethanolic Extract ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Identification And Characterization

Detection and characterization of ponatinib reactive metabolites by liquid chromatography tandem mass spectrometry and elucidation of bioactivation pathways

RSC Advances ◽  
2016 ◽  
Vol 6 (76) ◽  
pp. 72575-72585 ◽  
Author(s):  
Adnan A. Kadi ◽  
Hany W. Darwish ◽  
Mohamed W. Attwa ◽  
Sawsan M. Amer
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Reactive Metabolites ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Trapping Agent ◽  
Identification And Characterization

This study involved the identification and characterization of ponatinib by LC-MS/MS. Additionally ponatinib reactive metabolites were also investigated using KCN as a trapping agent, showing the formation of four reactive cyano adducts.

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