Studies on the minor metabolite 6a-hydroxy-androstenedione for doping control purposes and its contribution to the steroid profile

2014 ◽  
Vol 6 (10) ◽  
pp. 978-984 ◽  
Author(s):  
Michael Polet ◽  
Pieter Van Renterghem ◽  
Wim Van Gansbeke ◽  
Peter Van Eenoo

2017 ◽  
Vol 9 (11-12) ◽  
pp. 1779-1787 ◽  
Author(s):  
Jingzhu Wang ◽  
Yi He ◽  
Xin Liu ◽  
Zhiyong Yang ◽  
Wenning Yang


2018 ◽  
Vol 10 (9) ◽  
pp. 1458-1468 ◽  
Author(s):  
I. Athanasiadou ◽  
S. Kraiem ◽  
S. Al-Sowaidi ◽  
H. Al-Mohammed ◽  
N. Dbes ◽  
...  


2008 ◽  
Vol 43 (7) ◽  
pp. 877-891 ◽  
Author(s):  
Ute Mareck ◽  
Hans Geyer ◽  
Georg Opfermann ◽  
Mario Thevis ◽  
Wilhelm Schänzer


2001 ◽  
Vol 289 (2) ◽  
pp. 116-123 ◽  
Author(s):  
Rafael de la Torre ◽  
Xavier de la Torre ◽  
Concepción Alı́a ◽  
Jordi Segura ◽  
Teresa Baró ◽  
...  


2020 ◽  
Vol 17 (1) ◽  
pp. 31-39
Author(s):  
Marilene Lopes Ângelo ◽  
Fernanda de Lima Moreira ◽  
Ana Laura Araújo Santos ◽  
Hérida Regina Nunes Salgado ◽  
Magali Benjamim de Araújo

Background:: Tibolone is a synthetic steroid commercialized by Organon under the brand name Livial (Org OD14), which is used in hormone therapy for menopause management and treatment of postmenopausal osteoporosis. Tibolone is defined as a selective tissue estrogenic activity regulator (STEAR) demonstrating tissue-specific effects on several organs such as brain, breast, urogenital tract, endometrium, bone and cardiovascular system. Aims:: This work aims to (1) present an overview of important published literature on existing methods for the analysis of tibolone and/or its metabolites in pharmaceutical formulations and biological fluids and (2) to conduct a critical comparison of the analytical methods used in doping control, pharmacokinetics and pharmaceutical formulations analysis of tibolone and its metabolites. Results and conclusions: : The major analytical method described for the analysis of tibolone in pharmaceutical formulations is High Pressure Liquid Chromatography (HPLC) coupled with ultraviolet (UV) detection, while Liquid Chromatography (LC) or Gas Chromatography (GC) used in combination with Mass Spectrometry (MS) or tandem mass spectrometry (MS/MS) is employed for the analysis of tibolone and/or its metabolites in biological fluids.



Author(s):  
Austin J. Snyder ◽  
Jacob M. Gibbs ◽  
Manoj K. Jamarkattel ◽  
Adam B. Phillips ◽  
Michael J. Heben
Keyword(s):  


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