An optimized SDS‐PAGE protocol with a new blotting system for the initial testing procedure of ESAs in doping control

2020 ◽  
Author(s):  
Laurent Martin ◽  
Jean‐Antoine Martin ◽  
Michel Audran ◽  
Alexandre Marchand
Keyword(s):  
Testing Procedure ◽  
Doping Control ◽  
Initial Testing ◽  
In Doping ◽  
Sds Page

SDS-PAGE of recombinant and endogenous erythropoietins: benefits and limitations of the method for application in doping control

2009 ◽  
Vol 1 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Christian Reichel ◽  
Ronald Kulovics ◽  
Veronika Jordan ◽  
Martina Watzinger ◽  
Thomas Geisendorfer
Keyword(s):  
Doping Control ◽  
In Doping ◽  
Sds Page

A Review of Analytical Methods for the Determination of Tibolone: Pharmacokinetics and Pharmaceutical Formulations Analysis and Application in Doping Control

2020 ◽  
Vol 17 (1) ◽  
pp. 31-39
Author(s):  
Marilene Lopes Ângelo ◽  
Fernanda de Lima Moreira ◽  
Ana Laura Araújo Santos ◽  
Hérida Regina Nunes Salgado ◽  
Magali Benjamim de Araújo
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Analytical Methods ◽  
Estrogenic Activity ◽  
Biological Fluids ◽  
Pharmaceutical Formulations ◽  
Doping Control ◽  
Specific Effects ◽  
In Doping

Background:: Tibolone is a synthetic steroid commercialized by Organon under the brand name Livial (Org OD14), which is used in hormone therapy for menopause management and treatment of postmenopausal osteoporosis. Tibolone is defined as a selective tissue estrogenic activity regulator (STEAR) demonstrating tissue-specific effects on several organs such as brain, breast, urogenital tract, endometrium, bone and cardiovascular system. Aims:: This work aims to (1) present an overview of important published literature on existing methods for the analysis of tibolone and/or its metabolites in pharmaceutical formulations and biological fluids and (2) to conduct a critical comparison of the analytical methods used in doping control, pharmacokinetics and pharmaceutical formulations analysis of tibolone and its metabolites. Results and conclusions: : The major analytical method described for the analysis of tibolone in pharmaceutical formulations is High Pressure Liquid Chromatography (HPLC) coupled with ultraviolet (UV) detection, while Liquid Chromatography (LC) or Gas Chromatography (GC) used in combination with Mass Spectrometry (MS) or tandem mass spectrometry (MS/MS) is employed for the analysis of tibolone and/or its metabolites in biological fluids.

Qualitative screening in doping control by MALDI-TOF/TOF mass spectrometry: A proof-of-evidence

2012 ◽  
Vol 71 ◽  
pp. 193-197 ◽  
Author(s):  
E. Galano ◽  
M. Fidani ◽  
F. Baia ◽  
L. Palomba ◽  
G. Marino ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Doping Control ◽  
Maldi Tof ◽  
In Doping

Application of the new ion trap detector in doping control

1988 ◽  
Vol 6 (6-8) ◽  
pp. 987-993
Author(s):  
E.G. de Jong ◽  
R.A.A. Maes ◽  
J.M. van Rossum
Keyword(s):  
Ion Trap ◽  
Doping Control ◽  
Trap Detector ◽  
In Doping

Evaluation of AMGEN clone 9G8A anti-Epo antibody for application in doping control

2016 ◽  
Vol 8 (11-12) ◽  
pp. 1131-1137 ◽  
Author(s):  
Christian Reichel ◽  
Wolfgang Benetka ◽  
Barbara Lorenc ◽  
Mario Thevis
Keyword(s):  
Doping Control ◽  
In Doping
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