scholarly journals Fecundity compensation is dependent on the generalized stress response in a nematode host

2019 ◽  
Vol 9 (20) ◽  
pp. 11957-11961 ◽  
Author(s):  
Victoria L. Pike ◽  
Suzanne A. Ford ◽  
Kayla C. King ◽  
Charlotte Rafaluk‐Mohr
Keyword(s):  
Stress Response ◽  
Fecundity Compensation ◽  
Generalized Stress Response

Pesticide tolerance induced by a generalized stress response in wood frogs (Rana sylvatica)

Ecotoxicology ◽  
2020 ◽  
Vol 29 (9) ◽  
pp. 1476-1485
Author(s):  
Logan S. Billet ◽  
Jason T. Hoverman
Keyword(s):  
Stress Response ◽  
Rana Sylvatica ◽  
Wood Frogs ◽  
Pesticide Tolerance ◽  
Generalized Stress Response

scholarly journals Nitric oxide production in tobacco leaf cells: a generalized stress response?

2003 ◽  
Vol 26 (11) ◽  
pp. 1851-1862 ◽  
Author(s):  
K. S. GOULD ◽  
O. LAMOTTE ◽  
A. KLINGUER ◽  
A. PUGIN ◽  
D. WENDEHENNE
Keyword(s):  
Nitric Oxide ◽  
Stress Response ◽  
Nitric Oxide Production ◽  
Tobacco Leaf ◽  
Oxide Production ◽  
Generalized Stress Response

scholarly journals The Brucella abortus Lon functions as a generalized stress response protease and is required for wild-type virulence in BALB/c mice

2002 ◽  
Vol 35 (3) ◽  
pp. 577-588 ◽  
Author(s):  
Gregory T. Robertson ◽  
Michael E. Kovach ◽  
Chris A. Allen ◽  
Thomas A. Ficht ◽  
R. Martin Roop
Keyword(s):  
Stress Response ◽  
Brucella Abortus ◽  
Wild Type ◽  
Generalized Stress Response

scholarly journals Contrasting Responses of Lizards to Divergent Ecological Stressors Across Biological Levels of Organization

2019 ◽  
Vol 59 (2) ◽  
pp. 292-305 ◽  
Author(s):  
Rory S Telemeco ◽  
Dasia Y Simpson ◽  
Catherine Tylan ◽  
Tracy Langkilde ◽  
Tonia S Schwartz
Keyword(s):  
Stress Response ◽  
Cellular Response ◽  
Plasma Corticosterone ◽  
Cellular Level ◽  
Sceloporus Undulatus ◽  
Context Specific ◽  
Shock Proteins ◽  
Blood Glucose Concentrations ◽  
Red Imported Fire Ants ◽  
Generalized Stress Response

Abstract It is frequently hypothesized that animals employ a generalized “stress response,” largely mediated by glucocorticoid (GC) hormones, such as corticosterone, to combat challenging environmental conditions. Under this hypothesis, diverse stressors are predicted to have concordant effects across biological levels of an organism. We tested the generalized stress response hypothesis in two complementary experiments with juvenile and adult male Eastern fence lizards (Sceloporus undulatus). In both experiments, animals were exposed to diverse, ecologically-relevant, acute stressors (high temperature or red imported fire ants, Solenopsis invicta) and we examined their responses at three biological levels: behavioral; physiological (endocrine [plasma corticosterone and blood glucose concentrations] and innate immunity [complement and natural antibodies]); and cellular responses (gene expression of a panel of five heat-shock proteins in blood and liver) at 30 or 90 min post stress initiation. In both experiments, we observed large differences in the cellular response to the two stressors, which contrasts the similar behavioral and endocrine responses. In the adult experiment for which we had innate immune data, the stressors affected immune function independently, and they were correlated with CORT in opposing directions. Taken together, these results challenge the concept of a generalized stress response. Rather, the stress response was context specific, especially at the cellular level. Such context-specificity might explain why attempts to link GC hormones with life history and fitness have proved difficult. Our results emphasize the need for indicators at multiple biological levels and whole-organism examinations of stress.

scholarly journals The Transcriptome of Prematurely Aging Yeast Cells Is Similar to That of Telomerase-deficient Cells

2004 ◽  
Vol 15 (3) ◽  
pp. 1297-1312 ◽  
Author(s):  
Isabelle Lesur ◽  
Judith L. Campbell
Keyword(s):  
Stress Response ◽  
Life Span ◽  
Genome Instability ◽  
Glyoxylate Cycle ◽  
Yeast Cells ◽  
Environmental Stress Response ◽  
Isolated Cells ◽  
Repair Genes ◽  
Wild Type Yeast ◽  
Generalized Stress Response

To help define the pathologies associated with yeast cells as they age, we analyzed the transcriptome of young and old cells isolated by elutriation, which allows isolation of biochemical quantities of old cells much further advanced in their life span than old cells prepared by the biotin-streptavidin method. Both 18-generation-old wild-type yeast and 8-generation-old cells from a prematurely aging mutant (dna2-1), with a defect in DNA replication, were evaluated. Genes involved in gluconeogenesis, the glyoxylate cycle, lipid metabolism, and glycogen production are induced in old cells, signifying a shift toward energy storage. We observed a much more extensive generalized stress response known as the environmental stress response (ESR), than observed previously in biotin-streptavidin-isolated cells, perhaps because the elutriated cells were further advanced in their life span. In addition, there was induction of DNA repair genes that fall in the so-called DNA damage “signature” set. In the dna2-1 mutant, energy production genes were also induced. The response in the dna2-1 strain is similar to the telomerase delete response, genes whose expression changes during cellular senescence in telomerase-deficient cells. We propose that these results suggest, albeit indirectly, that old cells are responding to genome instability.

scholarly journals Bio-electrospraying and aerodynamically assisted bio-jetting the model eukaryotic Dictyostelium discoideum : assessing stress and developmental competency post treatment

2011 ◽  
Vol 8 (61) ◽  
pp. 1185-1191 ◽  
Author(s):  
Nicholl K. Pakes ◽  
Suwan N. Jayasinghe ◽  
Robin S. B. Williams
Keyword(s):  
Stress Response ◽  
Dictyostelium Discoideum ◽  
Immune Cell ◽  
Single Cells ◽  
Model Organism ◽  
Cell Types ◽  
Cell Development ◽  
Biomedical Model ◽  
Wide Range ◽  
Generalized Stress Response

Bio-electrospraying (BES) and aerodynamically assisted bio-jetting (AABJ) have recently been established as important novel biospray technologies for directly manipulating living cells. To elucidate their potential in medical and clinical sciences, these bio-aerosol techniques have been subjected to increasingly rigorous investigations. In parallel to these studies, we wish to introduce these unique biotechnologies for use in the basic biological sciences, for handling a wide range of cell types and systems, thus increasing the range and the scope of these techniques for modern research. Here, the authors present the analysis of the new use of these biospray techniques for the direct handling of the simple eukaryotic biomedical model organism Dictyostelium discoideum . These cells are widely used as a model for immune cell chemotaxis and as a simple model for development. We demonstrate that AABJ of these cells did not cause cell stress, as defined by the stress-gene induction, nor affect cell development. Furthermore, although BES induced the increased expression of one stress-related gene ( gapA ), this was not a generalized stress response nor did it affect cell development. These data suggest that these biospray techniques can be used to directly manipulate single cells of this biomedical model without inducing a generalized stress response or perturbing later development.

CarR, a MarR-family regulator from Corynebacterium glutamicum, modulated antibiotic and aromatic compound resistance

2019 ◽  
Vol 476 (21) ◽  
pp. 3141-3159 ◽  
Author(s):  
Meiru Si ◽  
Can Chen ◽  
Zengfan Wei ◽  
Zhijin Gong ◽  
GuiZhi Li ◽  
...  
Keyword(s):  
Stress Response ◽  
Ligand Binding ◽  
Corynebacterium Glutamicum ◽  
Conformational Changes ◽  
Cysteine Oxidation ◽  
Transcriptional Regulatory ◽  
Ligand Free ◽  
Redox Sensing

Abstract MarR (multiple antibiotic resistance regulator) proteins are a family of transcriptional regulators that is prevalent in Corynebacterium glutamicum. Understanding the physiological and biochemical function of MarR homologs in C. glutamicum has focused on cysteine oxidation-based redox-sensing and substrate metabolism-involving regulators. In this study, we characterized the stress-related ligand-binding functions of the C. glutamicum MarR-type regulator CarR (C. glutamicum antibiotic-responding regulator). We demonstrate that CarR negatively regulates the expression of the carR (ncgl2886)–uspA (ncgl2887) operon and the adjacent, oppositely oriented gene ncgl2885, encoding the hypothetical deacylase DecE. We also show that CarR directly activates transcription of the ncgl2882–ncgl2884 operon, encoding the peptidoglycan synthesis operon (PSO) located upstream of carR in the opposite orientation. The addition of stress-associated ligands such as penicillin and streptomycin induced carR, uspA, decE, and PSO expression in vivo, as well as attenuated binding of CarR to operator DNA in vitro. Importantly, stress response-induced up-regulation of carR, uspA, and PSO gene expression correlated with cell resistance to β-lactam antibiotics and aromatic compounds. Six highly conserved residues in CarR were found to strongly influence its ligand binding and transcriptional regulatory properties. Collectively, the results indicate that the ligand binding of CarR induces its dissociation from the carR–uspA promoter to derepress carR and uspA transcription. Ligand-free CarR also activates PSO expression, which in turn contributes to C. glutamicum stress resistance. The outcomes indicate that the stress response mechanism of CarR in C. glutamicum occurs via ligand-induced conformational changes to the protein, not via cysteine oxidation-based thiol modifications.

Syntax, Stress Response, and Speech Motor Control

2007 ◽  
Vol 17 (2) ◽  
pp. 25-26
Author(s):  
Jennifer Kleinow
Keyword(s):  
Motor Control ◽  
Stress Response ◽  
Speech Motor Control ◽  
Speech Motor

Eustress: The Positive Stress Response In Two Samples Of Nurses

2002 ◽  
Author(s):  
Bret L. Simmons ◽  
Debra L. Nelson
Keyword(s):  
Stress Response ◽  
Two Samples
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