scholarly journals A Phase 2a dose-escalation study of the safety, tolerability, pharmacokinetics and haemodynamic effects of BMS-986231 in hospitalized patients with heart failure with reduced ejection fraction

2017 ◽  
Vol 19 (10) ◽  
pp. 1321-1332 ◽  
Author(s):  
Cristina Tita ◽  
Edward M. Gilbert ◽  
Adrian B. Van Bakel ◽  
Jacek Grzybowski ◽  
Garrie J. Haas ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Dose Escalation ◽  
Haemodynamic Effects ◽  
Hospitalized Patients ◽  
Dose Escalation Study ◽  
Reduced Ejection Fraction ◽  
Patients With Heart Failure

Virtual optimization of guideline‐directed medical therapy in hospitalized patients with heart failure with reduced ejection fraction: the IMPLEMENT‐HF pilot study

2021 ◽  
Author(s):  
Ankeet S. Bhatt ◽  
Anubodh S. Varshney ◽  
Mahan Nekoui ◽  
Alea Moscone ◽  
Jonathan W. Cunningham ◽  
...  
Keyword(s):  
Heart Failure ◽  
Pilot Study ◽  
Ejection Fraction ◽  
Medical Therapy ◽  
Hospitalized Patients ◽  
Reduced Ejection Fraction ◽  
Patients With Heart Failure

scholarly journals Guideline Adherence of β-blocker Initiating Dose and its Consequence in Hospitalized Patients With Heart Failure With Reduced Ejection Fraction

2021 ◽  
Vol 12 ◽  
Author(s):  
Yiling Zhou ◽  
Yuping Zeng ◽  
Si Wang ◽  
Nan Li ◽  
Miye Wang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Dose Reduction ◽  
Guideline Adherence ◽  
Standard Dose ◽  
Hospitalized Patients ◽  
Adherence To Guidelines ◽  
Reduced Ejection Fraction ◽  
Patients With Heart Failure ◽  
Β Blocker

Background: We aim to investigate the guideline adherence of β-blocker (BB) initiating dose in Chinese hospitalized patients with heart failure with reduced ejection fraction (HFrEF) and whether the adherence affected the in-hospital outcomes.Methods: This was a retrospective study of patients hospitalized with HFrEF who had initiated BBs during their hospitalization. We defined adherence to clinical practice guidelines as initiating BB with standard dose and non-adherence to guidelines if otherwise, and examined the association between adherence to guidelines and in-hospital BB-related adverse events. Subgroup analyses based on sex, age, coronary heart disease, and hypertension were performed.Results: Among 1,104 patients with HFrEF initiating BBs during hospitalization (median length of hospitalization, 12 days), 304 (27.5%) patients received BB with non-adherent initiating dose. This non-adherence was related to a higher risk (hazard ratio [95% confidence interval]) of BB dose reduction or withdrawal (1.78 [1.42 to 2.22], P < 0.001), but not significantly associated with risks of profound bradycardia, hypotension, cardiogenic shock requiring intravenous inotropes, and severe bronchospasm requiring intravenous steroid during hospitalization.Conclusion: This study identified that over a fourth of patients had received BBs with an initiating dose that was not adherent to guidelines in Chinese hospitalized patients with HFrEF, and this non-adherence was associated with BB dose reduction or withdrawal during hospitalization.

Sacubitril/Valsartan Initiated in Hospitalized Patients with Heart Failure with Reduced Ejection Fraction after Hemodynamic Stabilization: Primary Results of the TRANSITION Study

2018 ◽  
Vol 24 (8) ◽  
pp. S15 ◽  
Author(s):  
Rolf Wachter ◽  
Michele Senni ◽  
Jan Belohlavek ◽  
Dmytro Butylin ◽  
Adele Noe ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Hospitalized Patients ◽  
Reduced Ejection Fraction ◽  
Patients With Heart Failure ◽  
Transition Study

Rate of Rehospitalization in 60 Days of Discharge and It's Determinants in Patients with Heart Failure with Reduced Ejection Fraction in a Tertiary Care Centre in India

2020 ◽  
Vol 2 (2) ◽  
pp. 131
Author(s):  
Kakasaheb H. Bhosale ◽  
Ranjit Kumar Nath ◽  
Neeraj Pandit ◽  
Puneet Agarwal ◽  
Shripad Khairnar ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Reduced Ejection Fraction ◽  
Patients With Heart Failure

Baroreflex Activation Therapy (BAT) in Patients with Heart Failure and a Reduced Ejection Fraction (HFrEF): The BeAT-HF Trial

2019 ◽  
Author(s):  
Michael Zile ◽  
JoAnn Lindenfeld ◽  
Fred A. Weaver ◽  
Faiez Zannad ◽  
Elizabeth Galle ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Baroreflex Activation Therapy ◽  
Reduced Ejection Fraction ◽  
Patients With Heart Failure ◽  
Activation Therapy
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