Differential modulation of T helper type 1 (Th1) and T helper type 2 (Th2) cytokine secretion by prostaglandin E2 critically depends on interleukin-2

1995 ◽  
Vol 25 (1) ◽  
pp. 59-63 ◽  
Author(s):  
Catharien M. U. Hilkens ◽  
Hans Vermeulen ◽  
R. J. Joost van Neerven ◽  
Frank G. M. Snijdewint ◽  
Eddy A. Wierenga ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Interleukin 2 ◽  
Cytokine Secretion ◽  
Differential Modulation ◽  
T Helper ◽  
Th2 Cytokine ◽  
Helper Type

scholarly journals CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4.

1993 ◽  
Vol 178 (5) ◽  
pp. 1645-1653 ◽  
Author(s):  
J G McArthur ◽  
D H Raulet
Keyword(s):  
Interleukin 2 ◽  
Interleukin 4 ◽  
Th2 Cells ◽  
T Helper ◽  
Autocrine Growth ◽  
Th Cells ◽  
Antigen Presenting ◽  
Helper Type

Type 1 and type 2 cloned T helper (Th) cells are believed to require different antigen-presenting cell (APC)-derived costimuli for proliferation. In the case of Th1-cloned T cells, CD28 signaling costimulates production of autocrine interleukin 2 (IL-2). Th2 cells produce their autocrine growth factor, IL-4, without costimulation, but require APC-derived costimuli, or IL-1, to respond to IL-4. Here we demonstrate that engagement of CD28 on Th2 cells with anti-CD28 antibody or with APC-associated B7 costimulates Th2 responsiveness to IL-4 but does not affect IL-4 or IL-2 production by Th2 cells. Costimulation of Th2 cells via CD28 appears to involve the induction of IL-1 production by Th2 cells, which acts in an autocrine fashion to induce IL-4 responsiveness. These results suggest that CD28-induced costimulation plays an important role in responses mediated by both types of Th cells.

Peyer's patch CD8+ memory T cells secrete T helper type 1 and type 2 cytokines and provide help for immunoglobulin secretion

1994 ◽  
Vol 24 (12) ◽  
pp. 3087-3092 ◽  
Author(s):  
Anand S. Lagoo ◽  
John H. Eldridge ◽  
Sandhya Lagoo-Deenadaylan ◽  
C. Allen Black ◽  
Ben U. Ridwan ◽  
...  
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
T Helper ◽  
Peyer's Patch ◽  
Immunoglobulin Secretion ◽  
Type 2 Cytokines ◽  
Cd8 Memory T Cells ◽  
Helper Type

scholarly journals Neurotransmitter signalling via NMDA receptors leads to decreased T helper type 1-like and enhanced T helper type 2-like immune balance in humans

Immunology ◽  
2017 ◽  
Vol 153 (3) ◽  
pp. 368-379 ◽  
Author(s):  
Kanami Orihara ◽  
Solomon O. Odemuyiwa ◽  
William P. Stefura ◽  
Ramses Ilarraza ◽  
Kent T. HayGlass ◽  
...  
Keyword(s):  
Nmda Receptors ◽  
T Helper ◽  
Immune Balance ◽  
Helper Type

scholarly journals Disruption of Rxra gene in thymocytes and T lymphocytes modestly alters lymphocyte frequencies, proliferation, survival and T helper type 1/type 2 balance

Immunology ◽  
2007 ◽  
Vol 121 (4) ◽  
pp. 484-498 ◽  
Author(s):  
Charles B. Stephensen ◽  
Alexander D. Borowsky ◽  
Kevin C. Kent Lloyd
Keyword(s):  
T Lymphocytes ◽  
T Helper ◽  
Helper Type
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