scholarly journals Activation of virus-specific major histocompatibility complex class II-restricted CD8+ cytotoxic T cells in CD4-deficient mice

1995 ◽  
Vol 25 (4) ◽  
pp. 1109-1112 ◽  
Author(s):  
Mirjam H. M. Heemskerk ◽  
Marco W. Schilham ◽  
Henriette M. Schoemaker ◽  
Gerrit Spierenburg ◽  
Willy J. M. Spaan ◽  
...  
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Cytotoxic T Cells ◽  
Class Ii ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Deficient Mice

scholarly journals Vaccination with Minigenes Encoding VH-derived Major Histocompatibility Complex Class I–binding Epitopes Activates Cytotoxic T Cells that Ablate Autoantibody-producing B Cells and Inhibit Lupus

2002 ◽  
Vol 196 (6) ◽  
pp. 731-741 ◽  
Author(s):  
Guo-Chang Fan ◽  
Ram Raj Singh
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
B Cells ◽  
Major Histocompatibility Complex Class ◽  
Cytotoxic T Cells ◽  
Variable Region ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

Current treatments for autoantibody-mediated diseases, such as lupus, can cause nonspecific immune suppression. In this paper, we used a bioinformatic approach to identify major histocompatibility complex class I–binding epitopes in the heavy chain variable region of anti-DNA antibodies from lupus-prone (NZB/NZW F1) mice. Vaccination of such mice with plasmid DNA vectors encoding these epitopes induced CD8+ T cells that killed anti-DNA antibody-producing B cells, reduced serum anti-DNA antibody levels, retarded the development of nephritis, and improved survival. Vaccine-mediated induction of anti-VH cytotoxic T lymphocytes that ablate autoreactive B cells represents a novel approach to treat autoantibody-mediated diseases.

scholarly journals Direct Staining with Major Histocompatibility Complex Class II Dextramers Permits Detection of Antigen-Specific, Autoreactive CD4 T Cells In Situ

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e87519 ◽  
Author(s):  
Chandirasegaran Massilamany ◽  
Arunakumar Gangaplara ◽  
Ting Jia ◽  
Christian Elowsky ◽  
Guobin Kang ◽  
...  
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Cd4 T Cells ◽  
Class Ii ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

scholarly journals Antigen Presentation by Dendritic Cells after Immunization with DNA Encoding a Major Histocompatibility Complex Class II–restricted Viral Epitope

1997 ◽  
Vol 186 (9) ◽  
pp. 1481-1486 ◽  
Author(s):  
Sofia Casares ◽  
Kayo Inaba ◽  
Teodor-Doru Brumeanu ◽  
Ralph M. Steinman ◽  
Constantin A. Bona
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Antigen Presentation ◽  
Class Ii ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Dna Encoding ◽  
Histocompatibility Complex

Intramuscular and intracutaneous immunization with naked DNA can vaccinate animals to the encoded proteins, but the underlying mechanisms of antigen presentation are unclear. We used DNA that encodes an A/PR/8/34 influenza peptide for CD4 T cells and that elicits protective antiviral immunity. DNA-transfected, cultured muscle cells released the influenza polypeptide, which then could be presented on the major histocompatibility complex class II molecules of dendritic cells. When DNA was injected into muscles or skin, and antigen-presenting cells were isolated from either the draining lymph nodes or the skin, dendritic, but not B, cells presented antigen to T cells and carried plasmid DNA. We suggest that the uptake of DNA and/or the protein expressed by dendritic cells triggers immune responses to DNA vaccines.

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