Down-regulation of class II major histocompatibility complex molecules on antigen presenting cells after interaction with helper T cells

1995 ◽  
Vol 25 (5) ◽  
pp. 1326-1331 ◽  
Author(s):  
Damir Vidović ◽  
Fiorenza Falcioni ◽  
David R. Bolin ◽  
Zoltan A. Nagy
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Antigen Presenting Cells ◽  
Class Ii ◽  
Helper T Cells ◽  
Major Histocompatibility ◽  
Down Regulation ◽  
Complex Molecules ◽  
Histocompatibility Complex ◽  
Antigen Presenting

scholarly journals Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 ◽  
Vol 194 (4) ◽  
pp. 427-438 ◽  
Author(s):  
Steven J. Bensinger ◽  
Antonio Bandeira ◽  
Martha S. Jordan ◽  
Andrew J. Caton ◽  
Terri M. Laufer
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Mhc Class Ii ◽  
Antigen Presenting Cells ◽  
Class Ii ◽  
Histocompatibility Complex ◽  
Antigen Presenting ◽  
Immunoregulatory T Cells ◽  
Deficient Mice ◽  
Selection Of

CD4+25+ T cells are a unique population of immunoregulatory T cells which are critical for the prevention of autoimmunity. To address the thymic selection of these cells we have used two models of attenuated thymic deletion. In K14-Aβb mice, major histocompatibility complex (MHC) class II I-Ab expression is limited to thymic cortical epithelium and deletion by hematopoietic antigen-presenting cells does not occur. In H2-DMα–deficient mice, MHC class II molecules contain a limited array of self-peptides resulting in inefficient clonal deletion. We find that CD4+25+ T cells are present in the thymus and periphery of K14-Aβb and H2-DMα–deficient mice and, like their wild-type counterparts, suppress the proliferation of cocultured CD4+25− effector T cells. In contrast, CD4+25+ T cells from MHC class II–deficient mice do not suppress responder CD4+ T cells in vitro or in vivo. Thus, development of regulatory CD4+25+ T cells is dependent on MHC class II-positive thymic cortical epithelium. Furthermore, analysis of the specificities of CD4+25+ T cells in K14-Aβb and H2-DMα–deficient mice suggests that a subset of CD4+25+ T cells is subject to negative selection on hematopoietic antigen-presenting cells.

Extrathymic selection of TCR γδ+ T cells by class II major histocompatibility complex molecules

Cell ◽  
1990 ◽  
Vol 63 (2) ◽  
pp. 333-340 ◽  
Author(s):  
Leo Lefrancois ◽  
Rozenne LeCorre ◽  
Judy Mayo ◽  
Jeffrey A. Bluestone ◽  
Thomas Goodman
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Γδ T Cells ◽  
Class Ii ◽  
Major Histocompatibility ◽  
Complex Molecules ◽  
Histocompatibility Complex ◽  
Selection Of
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