Blockade of bradykinin receptors or angiotensin II type 2 receptor prevents paclitaxel‐associated acute pain syndrome in mice

2020 ◽  
Vol 25 (1) ◽  
pp. 189-198
Author(s):  
Graziele C. Zanata ◽  
Larissa G. Pinto ◽  
Nicole R. Silva ◽  
Alexandre H. P. Lopes ◽  
Francisco F. B. Oliveira ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Acute Pain ◽  
Pain Syndrome ◽  
Bradykinin Receptors

Type-2 Angiotensin II Receptor

2020 ◽  
Author(s):  
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Ii Receptor

Anti-Hypertensive Potential and Epigenetics of Angiotensin II type 2 Receptor (AT2R)

2020 ◽  
Vol 16 ◽  
Author(s):  
Mayank Chaudhary
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Renin Angiotensin System ◽  
Blood Pressure Regulation ◽  
Biologically Active ◽  
Pressure Regulation ◽  
Tissue Remodelling ◽  
Critical Pathway

Background:: Renin angiotensin system (RAS) is a critical pathway involved in blood pressure regulation. Octapeptide, angiotensin II (Ang aII), is biologically active compound of RAS pathway which mediates its action by binding to either angiotensin II type 1 receptor (AT1R) or angiotensin II type 2 receptor (AT2R). Binding of Ang II to AT1R facilitates blood pressure regulation whereas AT2R is primarily involved in wound healing and tissue remodelling. Objective:: Recent studies have highlighted additional role of AT2R to counter balance detrimental effects of AT1R. Activation of angiotensin II type 2 receptor using AT2R agonist has shown effect on natriuresis and release of nitric oxide. Additionally, AT2R activation has been found to inhibit angiotensin converting enzyme (ACE) and enhance angiotensin receptor blocker (ARB) activity. These findings highlight the potential of AT2R as novel therapeutic target against hypertension. Conclusion:: The potential role of AT2R highlights the importance of exploring additional mechanisms that might be crucial for AT2R expression. Epigenetic mechanisms including DNA methylation and histone modification have been explored vastly with relation to cancer but role of such mechanisms on expression of AT2R has recently gained interest.

scholarly journals Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury

2018 ◽  
Vol Volume 11 ◽  
pp. 169-178 ◽  
Author(s):  
Mario Menk ◽  
Jan Adriaan Graw ◽  
Clarissa von Haefen ◽  
Henrik Kurt Alexander Steinkraus ◽  
Burkhard Lachmann ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Angiotensin Ii ◽  
Lung Injury ◽  
Receptor Agonist ◽  
Pulmonary Inflammation ◽  
Compound 21

Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter region

1995 ◽  
Vol 1262 (2-3) ◽  
pp. 155-158 ◽  
Author(s):  
Shun-ichi Kobayashi ◽  
Junji Ohnishi ◽  
Yutaka Nibu ◽  
Shin-ichiro Nishimatsu ◽  
Satoshi Umemura ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Promoter Region ◽  
Receptor Gene

scholarly journals Nitric Oxide Mediates Benefits of Angiotensin II Type 2 Receptor Overexpression During Post-Infarct Remodeling

Hypertension ◽  
2004 ◽  
Vol 43 (3) ◽  
pp. 680-685 ◽  
Author(s):  
Christina M. Bove ◽  
Zequan Yang ◽  
Wesley D. Gilson ◽  
Frederick H. Epstein ◽  
Brent A. French ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii

Blockade of central angiotensin II type 1 and type 2 receptors suppresses adrenalectomy-induced NaCl intake in rats

1996 ◽  
Vol 66 (1-2) ◽  
pp. 47-50 ◽  
Author(s):  
O. Galaverna ◽  
C. Polidori ◽  
R.R. Sakai ◽  
F. Liénard ◽  
S.Y. Chow ◽  
...  
Keyword(s):  
Angiotensin Ii

scholarly journals The angiotensin II type 2 receptor in the brain

2009 ◽  
Vol 11 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Masatsugu Horiuchi ◽  
Masaki Mogi ◽  
Masaru Iwai
Keyword(s):  
Angiotensin Ii ◽  
The Brain
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