Abstract
Background
Potential links between population exposure to organochlorine pesticides (OCPs) and their impact on human health are under discussion. The current study explored the effects of population OCP intake from plant-origin food consumption on lipid metabolism and inflammation using a multiple follow-up study.
Methods
A total of 10 childbearing-age women (five in urban areas and five in rural areas) in northern China were recruited and visited for five times. During each visit, we conducted a questionnaire survey, blood collection, and food sampling. The levels of OCPs in cereals, fruits, and vegetables were measured, and nutrient content information was obtained from a national monitoring program. We calculated the women’s dietary intakes of OCPs and nutrients. Serum biomarkers of lipids [triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL), and lipoprotein(a)], monocyte chemotactic protein-1, interleukin (IL)-6, and IL-8 were measured. Linear mixed-effect models were used to evaluate the associations of dietary OCP and nutrient intake with serum biomarkers.
Results
The dietary intake of p,p′-dichlorodiphenyltrichloroethane (DDT) [β = -10.11, 95% confidence interval (95%CI): -17.32, -2.905] and o,p′-dichlorodiphenyldichloroethylene (DDE) (β = -6.077, 95%CI: -9.954, -2.200) were overall negatively associated with serum HDL, whereas other OCPs were not. IL-8 was positively associated with intake of dieldrin (β = 0.390, 95% CI: 0.105, 0.674), endosulfan-β (β = 0.361, 95%CI: 0.198, 0.523), total endosulfan (β = 0.136, 95%CI: 0.037, 0.234), and total OCPs (β = 0.084, 95%CI: 0.016, 0.153), and negatively correlated with intake of p,p′-DDE (β = -2.692, 95%CI: -5.185, -0.198). No associations between dietary nutrient intake and serum biomarkers were observed.
Conclusions
We concluded that dietary intake of some individual DDT-, DDE- dieldrin-, and endosulfan-class chemicals from plant-origin foods may interfere with lipid metabolism and inflammation responses.
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