scholarly journals Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells

2001 ◽  
Vol 33 (1) ◽  
pp. 82-92 ◽  
Author(s):  
Martin F. Arlt ◽  
Diane E. Miller ◽  
David G. Beer ◽  
Thomas W. Glover
Keyword(s):  
Cancer Cells ◽  
Molecular Characterization ◽  
Fragile Site ◽  
Common Fragile Site

Molecular characterization of the human common fragile site FRA1H

2007 ◽  
Vol 46 (5) ◽  
pp. 487-493 ◽  
Author(s):  
Angela Curatolo ◽  
Zaira M. Limongi ◽  
Franca Pelliccia ◽  
Angela Rocchi
Keyword(s):  
Molecular Characterization ◽  
Fragile Site ◽  
Common Fragile Site

scholarly journals Molecular characterization of exosome-like vesicles from breast cancer cells

BMC Cancer ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Stefan Kruger ◽  
Zakaria Y Abd Elmageed ◽  
David H Hawke ◽  
Philipp M Wörner ◽  
David A Jansen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Molecular Characterization ◽  
Breast Cancer Cells

Molecular characterization of minimal residual cancer cells in patients with solid tumors

2001 ◽  
Vol 17 (3) ◽  
pp. 95-111 ◽  
Author(s):  
Beatrix Böckmann ◽  
Hans-Jörg Grill ◽  
Michael Giesing
Keyword(s):  
Cancer Cells ◽  
Solid Tumors ◽  
Molecular Characterization ◽  
Residual Cancer ◽  
Minimal Residual Cancer ◽  
Minimal Residual

scholarly journals Molecular characterization of type I IFN-induced cytotoxicity in bladder cancer cells reveals biomarkers of resistance

2021 ◽  
Author(s):  
Jennifer L. Green ◽  
Robin Osterhout ◽  
Amy L. Klova ◽  
Carsten Merkwirth ◽  
Scott R.P. McDonnell ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Molecular Characterization ◽  
Type I ◽  
Type I Ifn ◽  
Bladder Cancer Cells

scholarly journals An integrated enrichment system to facilitate isolation and molecular characterization of single cancer cells from whole blood

2018 ◽  
Vol 93 (12) ◽  
pp. 1226-1233 ◽  
Author(s):  
Liping Yu ◽  
Silin Sa ◽  
Ling Wang ◽  
Keely Dulmage ◽  
Neha Bhagwat ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Molecular Characterization ◽  
Whole Blood ◽  
Single Cancer

scholarly journals BRCA1 Is Required for Common-Fragile-Site Stability via Its G2/M Checkpoint Function

2004 ◽  
Vol 24 (15) ◽  
pp. 6701-6709 ◽  
Author(s):  
Martin F. Arlt ◽  
Bo Xu ◽  
Sandra G. Durkin ◽  
Anne M. Casper ◽  
Michael B. Kastan ◽  
...  
Keyword(s):  
Rna Interference ◽  
Tumor Suppressor ◽  
Dna Synthesis ◽  
Cancer Cells ◽  
Tumor Suppressor Genes ◽  
Fragile Site ◽  
Fragile Sites ◽  
Common Fragile Site ◽  
Interacting Proteins ◽  
Checkpoint Pathway

ABSTRACT Common fragile sites are loci that form chromosome gaps or breaks when DNA synthesis is partially inhibited. Fragile sites are prone to deletions, translocations, and other rearrangements that can cause the inactivation of associated tumor suppressor genes in cancer cells. It was previously shown that ATR is critical to fragile-site stability and that ATR-deficient cells have greatly elevated fragile-site expression (A. M. Casper, P. Nghiem, M. F. Arlt, and T. W. Glover, Cell 111:779-789, 2002). Here we demonstrate that mouse and human cells deficient for BRCA1, due to mutation or knockdown by RNA interference, also have elevated fragile-site expression. We further show that BRCA1 functions in the induction of the G2/M checkpoint after aphidicolin-induced replication stalling and that this checkpoint function is involved in fragile-site stability. These data indicate that BRCA1 is important in fragile-site stability and that fragile sites are recognized by the G2/M checkpoint pathway, in which BRCA1 plays a key role. Furthermore, they suggest that mutations in BRCA1 or interacting proteins could lead to rearrangements at fragile sites in cancer cells.

Abstract 252: Molecular characterization of cancer stem cells isolated from primary colon cancer cells.

2013 ◽  
Author(s):  
Martin Lange ◽  
Dirk Schumacher ◽  
Thomas Hauling ◽  
Christian Regenbrecht ◽  
Oliver Politz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Stem Cells ◽  
Cancer Cells ◽  
Molecular Characterization ◽  
Colon Cancer Cells ◽  
Primary Colon Cancer ◽  
Primary Colon

scholarly journals Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer

Oncogene ◽  
2004 ◽  
Vol 23 (41) ◽  
pp. 6872-6880 ◽  
Author(s):  
Lorène Rozier ◽  
Eliane El-Achkar ◽  
Françoise Apiou ◽  
Michelle Debatisse
Keyword(s):  
Fragile Site ◽  
Common Fragile Site ◽  
Inherited Disease

Independent Prognostication and Therapy Monitoring of Breast Cancer Patients by Dna/Rna Typing of Minimal Residual Cancer Cells

2000 ◽  
Vol 15 (1) ◽  
pp. 94-99 ◽  
Author(s):  
M. Giesing ◽  
F. Austrup ◽  
B. BÖckmann ◽  
G. Driesel ◽  
C. Eder ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Molecular Characterization ◽  
Therapy Monitoring ◽  
Breast Cancer Patients ◽  
Residual Cancer ◽  
Minimal Residual Cancer ◽  
Minimal Residual

Clinical relevance, purification techniques and molecular characterization of minimal residual cancer cells (MRCC) is a controversial topic in the literature. An analytical concept including a novel isolation procedure and a panel of tests for DNA and RNA typing of MRCCs is described and clinically evaluated in this paper. The purification procedure exploiting the physical characteristics of MRCCs shows superior performance leading to >50% pure and viable tumor cells. Proof of the presence and purity of MRCCs in an isolated sample is given by multiparametric DNA typing (amplifications, mutations, losses of heterozygosity). On the basis of the proven presence of MRCCs tumor-relevant mRNAs can be adequately analyzed by normalized quantitative real-time RT-PCR. The molecular characterization of MRCCs isolated from blood of breast cancer patients could have a strong clinical impact on prognostication, drug targeting and therapy monitoring.

Sign in / Sign up

Export Citation Format

Share Document