11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: Report from an International Workshop†

2001 ◽  
Vol 33 (4) ◽  
pp. 362-378 ◽  
Author(s):  
Clara D. Bloomfield ◽  
Kellie J. Archer ◽  
Krzysztof Mrózek ◽  
Debra M. Lillington ◽  
Yasuhiko Kaneko ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Myelodysplastic Syndromes ◽  
Chromosome Aberrations ◽  
International Workshop

Comparison of de novo vs. therapy-related acute leukemia (AL) and myelodysplastic syndromes (MDS) in adults with balanced chromosome aberrations of 11q23

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 6549-6549
Author(s):  
W. Blum ◽  
K. Mrózek ◽  
K. Maharry ◽  
S. C. Raimondi ◽  
A. J. Carroll ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Myelodysplastic Syndromes ◽  
Chromosome Aberrations ◽  
De Novo

Balanced chromosome abnormalities inv(16) and t(15;17) in therapy-related myelodysplastic syndromes and acute leukemia: Report from an International Workshop

2002 ◽  
Vol 33 (4) ◽  
pp. 395-400 ◽  
Author(s):  
Mette K. Andersen ◽  
Richard A. Larson ◽  
Nils Mauritzson ◽  
Susanne Schnittger ◽  
Suresh C. Jhanwar ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Myelodysplastic Syndromes ◽  
International Workshop ◽  
Chromosome Abnormalities

Rare recurring balanced chromosome abnormalities in therapy-related myelodysplastic syndromes and acute leukemia: Report from an International Workshop

2002 ◽  
Vol 33 (4) ◽  
pp. 401-412 ◽  
Author(s):  
AnneMarie W. Block ◽  
Andrew J. Carroll ◽  
Anne Hagemeijer ◽  
Lucienne Michaux ◽  
Kirsten van Lom ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Myelodysplastic Syndromes ◽  
International Workshop ◽  
Chromosome Abnormalities

Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells

2014 ◽  
Vol 38 (2) ◽  
pp. 251-257 ◽  
Author(s):  
João Agostinho Machado-Neto ◽  
Paula de Melo Campos ◽  
Patricia Favaro ◽  
Mariana Lazarini ◽  
Irene Lorand-Metze ◽  
...  
Keyword(s):  
High Risk ◽  
Acute Leukemia ◽  
Myelodysplastic Syndromes ◽  
Leukemia Cells ◽  
Stathmin 1

scholarly journals ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy

Blood ◽  
1993 ◽  
Vol 82 (2) ◽  
pp. 544-546 ◽  
Author(s):  
G Cimino ◽  
F Lo Coco ◽  
A Biondi ◽  
L Elia ◽  
A Luciano ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Tumor Cell ◽  
Chromosome Aberrations ◽  
Poor Prognosis ◽  
Genetic Locus ◽  
Genetic Defect ◽  
Early Infancy ◽  
Acute Leukemias ◽  
Chromosome 11Q23 ◽  
Characteristic Features

Abstract Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are characteristic features of a particular subset of childhood acute leukemias (AL). In these cases, chromosome aberrations at the 11q23 band are the most frequently reported cytogenetic abnormalities. We have recently cloned a genetic locus named ALL-1, in which DNA breakpoints are clustered in leukemic patients with 11q23 aberrations. Analysis of the ALL-1 genomic configuration in DNA from 15 infants with AL showed specific ALL-1 rearrangements in 12 cases (80%), including 5 with normal karyotypes. These findings indicate that a consistent genetic defect underlies this particular leukemic subset.

Treatment of acute leukemia arising from myelodysplastic syndromes with oral idarubicin, etoposide, and 6-thioguanine

1994 ◽  
Vol 18 ◽  
pp. 61
Author(s):  
M. Montillo ◽  
A. Tedeschi ◽  
A. Olivieri ◽  
R. Centurioni ◽  
G. Pelliccia ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Myelodysplastic Syndromes
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