Downregulation of steroidogenic acute regulatory protein (StAR) gene expression by cyclic AMP in cultured Schwann cells

Glia ◽  
2004 ◽  
Vol 45 (3) ◽  
pp. 213-228 ◽  
Author(s):  
Yasmina Benmessahel ◽  
Jean-Denis Troadec ◽  
Fran�oise Cadepond ◽  
Rachida Guennoun ◽  
Dale Buchanan Hales ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cyclic Amp ◽  
Schwann Cells ◽  
Regulatory Protein ◽  
Steroidogenic Acute Regulatory Protein ◽  
Cultured Schwann Cells ◽  
Steroidogenic Acute Regulatory ◽  
Star Gene

scholarly journals Porcine and Bovine Steroidogenic Acute Regulatory Protein (StAR) Gene Expression during Gestation1

Endocrinology ◽  
1997 ◽  
Vol 138 (3) ◽  
pp. 1085-1091 ◽  
Author(s):  
Nicolas Pilon ◽  
Isabelle Daneau ◽  
Chantal Brisson ◽  
Jean-François Ethier ◽  
Jacques G. Lussier ◽  
...  
Keyword(s):  
Gene Expression ◽  
Regulatory Protein ◽  
Steroidogenic Acute Regulatory Protein ◽  
Steroidogenic Acute Regulatory ◽  
Star Gene

Regulation of steroidogenic acute regulatory protein (StAR) gene expression in hamster adrenals

1998 ◽  
Vol 24 (3-4) ◽  
pp. 623-624
Author(s):  
A. Fleury ◽  
L. Ducharme ◽  
D. B. Hales ◽  
J. G. Lehoux
Keyword(s):  
Gene Expression ◽  
Regulatory Protein ◽  
Steroidogenic Acute Regulatory Protein ◽  
Steroidogenic Acute Regulatory ◽  
Star Gene

Expression of Steroidogenic Acute Regulatory Protein in Cultured Schwann Cells and Its Regulation by cAMP

2002 ◽  
Vol 973 (1) ◽  
pp. 83-87 ◽  
Author(s):  
Y. BENMESSAHEL ◽  
R. GUENNOUN ◽  
F. CADEPOND ◽  
E. E. BAULIEU ◽  
M. SCHUMACHER ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Regulatory Protein ◽  
Steroidogenic Acute Regulatory Protein ◽  
Cultured Schwann Cells ◽  
Steroidogenic Acute Regulatory

scholarly journals DAX-1 Expression in Human Adrenocortical Neoplasms: Implications for Steroidogenesis

1998 ◽  
Vol 83 (7) ◽  
pp. 2597-2600 ◽  
Author(s):  
M. Reincke ◽  
F. Beuschlein ◽  
E. Lalli ◽  
W. Arlt ◽  
S. Vay ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mrna Expression ◽  
Protein Gene ◽  
Regulatory Protein ◽  
Nuclear Hormone Receptor ◽  
Adrenocortical Tumors ◽  
Steroidogenic Acute Regulatory ◽  
Adrenocortical Carcinomas ◽  
Star Gene ◽  
Functional Phenotype

The DAX-1 gene encodes an orphan nuclear hormone receptor essential for normal fetal development of the adrenal cortex. Recently, DAX-1 has been shown to act as a transcriptional repressor of steroidogenic acute regulatory protein gene expression (StAR), suppressing steroidogenesis. We, therefore, investigated the expression of DAX-1 in a variety of adrenocortical tumors and compared the results with StAR mRNA expression. We found low or absent DAX-1 expression in aldosterone-producing adenomas (n=11: 35±11%; normal adrenals: 100±17%) and in aldosterone-producing adrenocortical carcinomas (n=2: 24 and 36%). Cortisol-producing adenomas showed intermediate DAX-1 expression (n=8; 92±16), as did 3 non-aldosterone-producing carcinomas (72, 132 and 132%). High DAX-1 expression was present in nonfunctional adenomas (n=3; 160±17%). In contrast to DAX-1, StAR mRNA expression did not show significant variations between groups. We did not detect the expected negative correlation between DAX-1 and StAR mRNA in adrenocortical tumors. These data suggest that high DAX-1 expression in adrenocortical tumors is associated with a non-functional phenotype whereas low DAX-1 expression favors mineralo-corticoid secretion. These effects on steroidogenesis are mediated by mechanisms other than repression of StAR gene expression. Our results indicate that DAX-1 may be one of the factors influencing the steroid biosynthesis of adrenocortical neoplasms.

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