scholarly journals The molecular machinery of myelin gene transcription in Schwann cells

Glia ◽  
2008 ◽  
Vol 56 (14) ◽  
pp. 1541-1551 ◽  
Author(s):  
John Svaren ◽  
Dies Meijer
Keyword(s):  
Schwann Cells ◽  
Gene Transcription ◽  
Molecular Machinery ◽  
Myelin Gene

Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells

2003 ◽  
Vol 23 (1) ◽  
pp. 13-27 ◽  
Author(s):  
David B Parkinson ◽  
Sarah Dickinson ◽  
Ambily Bhaskaran ◽  
Matthew T Kinsella ◽  
Peter J Brophy ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Myelin Gene

scholarly journals P0 Glycoprotein Overexpression Causes Congenital Hypomyelination of Peripheral Nerves

2000 ◽  
Vol 148 (5) ◽  
pp. 1021-1034 ◽  
Author(s):  
Lawrence Wrabetz ◽  
Maria Laura Feltri ◽  
Angelo Quattrini ◽  
Daniele Imperiale ◽  
Stefano Previtali ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Peripheral Nerves ◽  
Gene Dosage ◽  
Hereditary Neuropathy ◽  
Myelin Protein Zero ◽  
Low Copy Number ◽  
Nerve Development ◽  
Protein Zero ◽  
Dose Dependent ◽  
Myelin Gene

We show that normal peripheral nerve myelination depends on strict dosage of the most abundantly expressed myelin gene, myelin protein zero (Mpz). Transgenic mice containing extra copies of Mpz manifested a dose-dependent, dysmyelinating neuropathy, ranging from transient perinatal hypomyelination to arrested myelination and impaired sorting of axons by Schwann cells. Myelination was restored by breeding the transgene into the Mpz-null background, demonstrating that dysmyelination does not result from a structural alteration or Schwann cell-extrinsic effect of the transgenic P0 glycoprotein. Mpz mRNA overexpression ranged from 30–700%, whereas an increased level of P0 protein was detected only in nerves of low copy-number animals. Breeding experiments placed the threshold for dysmyelination between 30 and 80% Mpz overexpression. These data reveal new points in nerve development at which Schwann cells are susceptible to increased gene dosage, and suggest a novel basis for hereditary neuropathy.

Induction of Myelin Gene Expression in Murine Schwann Cells in Primary Culture and in a Schwann Cell Line

1999 ◽  
Vol 883 (1) ◽  
pp. 513-517
Author(s):  
S. M. NICHOLSON ◽  
D. GOMÈS ◽  
A. BARON-VAN EVERCOOREN ◽  
R. BRUZZONE
Keyword(s):  
Gene Expression ◽  
Schwann Cell ◽  
Primary Culture ◽  
Cell Line ◽  
Schwann Cells ◽  
Myelin Gene

Myelin Gene Expression in Immortalized Schwann Cells: Relationship to Cell Density and Proliferation

2002 ◽  
Vol 66 (4) ◽  
pp. 1432-1439 ◽  
Author(s):  
Naokazu Sasagasako ◽  
Kenichi Toda ◽  
Melissa Hollis ◽  
Richard H. Quarles
Keyword(s):  
Gene Expression ◽  
Schwann Cells ◽  
Cell Density ◽  
Myelin Gene ◽  
Immortalized Schwann Cells

Comparative analysis of Schwann cell lines as model systems for myelin gene transcription studies

2002 ◽  
Vol 69 (4) ◽  
pp. 497-508 ◽  
Author(s):  
Mehreen Hai ◽  
Naser Muja ◽  
George H. DeVries ◽  
Richard H. Quarles ◽  
Pragna I. Patel
Keyword(s):  
Comparative Analysis ◽  
Schwann Cell ◽  
Cell Lines ◽  
Gene Transcription ◽  
Model Systems ◽  
Myelin Gene
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