scholarly journals fMRI activation in late-life anxious depression: a potential biomarker

2009 ◽  
Vol 24 (8) ◽  
pp. 820-828 ◽  
Author(s):  
Carmen Andreescu ◽  
Meryl Butters ◽  
Eric J. Lenze ◽  
Vijay K. Venkatraman ◽  
Megan Nable ◽  
...  
Keyword(s):  
Late Life ◽  
Anxious Depression ◽  
Potential Biomarker

Late-Life Depression: Modifications of Brain Resting State Activity

2017 ◽  
Vol 30 (3) ◽  
pp. 140-150 ◽  
Author(s):  
Filippo Cieri ◽  
Roberto Esposito ◽  
Nicoletta Cera ◽  
Valentina Pieramico ◽  
Armando Tartaro ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Elderly Population ◽  
Rating Scale ◽  
Late Life ◽  
Group Differences ◽  
Depression Symptoms ◽  
Late Life Depression ◽  
Potential Biomarker ◽  
Intrinsic Connectivity

Late-life depression (LLD) is a common emotional and mental disability in the elderly population characterized by the presence of depressed mood, the loss of interest or pleasure in daily activities, and other depression symptoms. It has a serious effect on the quality of life of elderly individuals and increases their risk of developing physical and mental diseases. It is an important area of research, given the growing elderly population. Brain functional connectivity modifications represent one of the neurobiological biomarker for LLD even if to date remains poorly understood. In our study, we enrolled 10 elderly patients with depressive symptoms compared to 11 age-matched healthy controls. All participants were evaluated by means of neuropsychological tests and underwent the same functional magnetic resonance imaging (fMRI) protocol to evaluate modifications of brain resting state functional connectivity. Between-group differences were observed for the Geriatric Depression Scale and Hamilton Depression Rating Scale, with higher scores for patients with LLD. Voxel-wise, 1-way analysis of variance revealed between-group differences in left frontoparietal network (lFPN) and sensory motor network (SMN): Increased intrinsic connectivity in the LLD group was observed in the left dorsolateral prefrontal cortex and in the left superior parietal lobule of the lFPN and increased intrinsic connectivity in the LLD group was observed in the bilateral primary somatosensory cortex of the SMN. Our findings support the use of resting state fMRI as a potential biomarker for LLD; even if to confirm the relationship between brain changes and the pathophysiology of LLD, longitudinal neuroimaging studies are required.

scholarly journals Abnormalities of CSF flow patterns in the cerebral aqueduct in treatment-resistant late-life depression: A potential biomarker of microvascular angiopathy

2006 ◽  
Vol 56 (3) ◽  
pp. 509-516 ◽  
Author(s):  
Josephine H. Naish ◽  
Robert C. Baldwin ◽  
Tufail Patankar ◽  
Suzanne Jeffries ◽  
Alistair S. Burns ◽  
...  
Keyword(s):  
Late Life ◽  
Flow Patterns ◽  
Cerebral Aqueduct ◽  
Late Life Depression ◽  
Treatment Resistant ◽  
Csf Flow ◽  
Potential Biomarker

scholarly journals The Default Mode Network In Late-Life Anxious Depression

2011 ◽  
Vol 19 (11) ◽  
pp. 980-983 ◽  
Author(s):  
Carmen Andreescu ◽  
Minjie Wu ◽  
Meryl A. Butters ◽  
Jennifer Figurski ◽  
Charles F. Reynolds ◽  
...  
Keyword(s):  
Default Mode Network ◽  
Late Life ◽  
Default Mode ◽  
Anxious Depression

scholarly journals Clinical interventions for late-life anxious depression

2006 ◽  
Vol 1 (1) ◽  
pp. 41-50 ◽  
Author(s):  
Gretchen J Diefenbach ◽  
John Goethe
Keyword(s):  
Late Life ◽  
Clinical Interventions ◽  
Anxious Depression

The miR-21 potential of serving as a biomarker for liver diseases in clinical practice

2020 ◽  
Vol 48 (5) ◽  
pp. 2295-2305
Author(s):  
Jiawei Zhang ◽  
Dandan Li ◽  
Rui Zhang ◽  
Peng Gao ◽  
Rongxue Peng ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Liver Diseases ◽  
Hepatic Disease ◽  
Noninvasive Detection ◽  
Diagnosis And Prognosis ◽  
Expected Performance ◽  
Potential Biomarker ◽  
Disease Condition ◽  
Complex Regulatory Network

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.

Midlife HTN Tied to Late-Life Cortical Thinning

2011 ◽  
Vol 44 (6) ◽  
pp. 29
Author(s):  
MICHELE G. SULLIVAN
Keyword(s):  
Late Life ◽  
Cortical Thinning

Triglyceride to high density lipoprotein cholesterol ratio, total cholesterol to high density lipoprotein cholesterol ratio and low ankle brachial index in an elderly population

VASA ◽  
2014 ◽  
Vol 43 (3) ◽  
pp. 189-197 ◽  
Author(s):  
Yiqiang Zhan ◽  
Jinming Yu ◽  
Rongjing Ding ◽  
Yihong Sun ◽  
Dayi Hu
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Density Lipoprotein Cholesterol ◽  
Ankle Brachial Index ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Cholesterol Ratio ◽  
Potential Biomarker

Background: The associations of triglyceride (TG) to high-density lipoprotein cholesterol ratio (HDL‑C) and total cholesterol (TC) to HDL‑C ratio and low ankle brachial index (ABI) were seldom investigated. Patients and methods: A population based cross-sectional survey was conducted and 2982 participants 60 years and over were recruited. TG, TC, HDL‑C, and low-density lipoprotein cholesterol (LDL-C) were assessed in all participants. Low ABI was defined as ABI ≤ 0.9 in either leg. Multiple logistic regression models were applied to study the association between TG/HDL‑C ratio, TC/HDL‑C ratio and low ABI. Results: The TG/HDL‑C ratios for those with ABI > 0.9 and ABI ≤ 0.9 were 1.28 ± 1.20 and 1.48 ± 1.13 (P < 0.0001), while the TC/HDL‑C ratios were 3.96 ± 1.09 and 4.32 ± 1.15 (P < 0.0001), respectively. After adjusting for age, gender, body mass index, obesity, current drinking, physical activity, hypertension, diabetes, lipid-lowering drugs, and cardiovascular disease history, the odds ratios (ORs) with 95 % confidence intervals (CIs) of low ABI for TG/HDL‑C ratio and TC/HDL‑C ratio were 1.10 (0.96, 1.26) and 1.34 (1.14, 1.59) in non-smokers. When TC was further adjusted, the ORs (95 % CIs) were 1.40 (0.79, 2.52) and 1.53 (1.21, 1.93) for TG/HDL‑C ratio and TC/HDL‑C ratio, respectively. Non-linear relationships were detected between TG/HDL‑C ratio and TC/HDL‑C ratio and low ABI in both smokers and non-smokers. Conclusions: TC/HDL‑C ratio was significantly associated with low ABI in non-smokers and the association was independent of TC, TG, HDL‑C, and LDL-C. TC/HDL‑C might be considered as a potential biomarker for early peripheral arterial disease screening.

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