Potential role of micro-RNAs in head and neck tumorigenesis

Head & Neck ◽  
2010 ◽  
Vol 32 (8) ◽  
pp. 1099-1111 ◽  
Author(s):  
Nham Tran ◽  
Christopher J. O'Brien ◽  
Jonathan Clark ◽  
Barbara Rose
Keyword(s):  
Head And Neck ◽  
Potential Role ◽  
Micro Rnas

Hypopharyngeal Squamous Cell Carcinoma in Sisters with LMNA Associated Familial Partial Lipodystrophy: A Case Report and Review of the Literature

2020 ◽  
Vol 129 (12) ◽  
pp. 1243-1246
Author(s):  
Stephanie J. Youssef ◽  
Robert J. Macielak ◽  
Lisa A. Schimmenti ◽  
Kyriakos Chatzopoulos ◽  
Daniel L. Price
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Potential Role ◽  
Partial Lipodystrophy ◽  
Hypopharyngeal Squamous Cell Carcinoma ◽  
Familial Partial Lipodystrophy ◽  
Subcutaneous Adipose

Objectives: LMNA-associated familial partial lipodystrophy (FPLD) is a rare autosomal dominant A-type laminopathy characterized by variable loss and redistribution of subcutaneous adipose tissue, dyslipidemia, and insulin resistance. Though A-type lamins play a key role in nuclear membrane structure and regulation of cell proliferation, an association between cancer and LMNA-associated FPLD has not been reported. Methods and Results: This report outlines the case of two biological sisters with LMNA-associated FPLD who developed hypopharyngeal squamous cell carcinoma in the absence of any other risk factors for head and neck cancer. Conclusion: These observations prompt further investigation into the potential role of A-type lamins in the development and progression of head and neck cancers.

Potential role of microbiome in oncogenesis, outcome prediction and therapeutic targeting for head and neck cancer

Oral Oncology ◽  
2019 ◽  
Vol 99 ◽  
pp. 104453 ◽  
Author(s):  
Ester Orlandi ◽  
Nicola Alessandro Iacovelli ◽  
Vincenzo Tombolini ◽  
Tiziana Rancati ◽  
Antonella Polimeni ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Potential Role ◽  
Outcome Prediction ◽  
Therapeutic Targeting

scholarly journals Potential Role of PET/MRI for Imaging Metastatic Lymph Nodes in Head and Neck Cancer

2016 ◽  
Vol 207 (2) ◽  
pp. 248-256 ◽  
Author(s):  
Sungheon Gene Kim ◽  
Kent Friedman ◽  
Sohil Patel ◽  
Mari Hagiwara
Keyword(s):  
Head And Neck Cancer ◽  
Lymph Nodes ◽  
Head And Neck ◽  
Neck Cancer ◽  
Potential Role ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

scholarly journals Towards a molecular basis of oligometastatic disease: potential role of micro-RNAs

2014 ◽  
Vol 31 (6) ◽  
pp. 735-748 ◽  
Author(s):  
Abhineet Uppal ◽  
Mark K. Ferguson ◽  
Mitchell C. Posner ◽  
Samuel Hellman ◽  
Nikolai N. Khodarev ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Potential Role ◽  
Oligometastatic Disease ◽  
Micro Rnas

scholarly journals Interaction between Chronic Inflammation and Oral HPV Infection in the Etiology of Head and Neck Cancers

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Mine Tezal
Keyword(s):  
Head And Neck ◽  
Chronic Inflammation ◽  
Potential Role ◽  
Hpv Infection ◽  
Oral Tongue ◽  
Papillomavirus Infection ◽  
Prevention And Treatment ◽  
Oral Hpv ◽  
Base Of The Tongue

Incidences of oral tongue, base of the tongue, and tonsil cancers have been increasing steadily in many parts of the world in spite of declining rates of tobacco use over the last four decades. A better understanding of the etiology, interactions between risk factors, and new approaches to prevention and treatment are necessary to change this course. This paper will present evidence supporting a potential role of chronic inflammation in the etiologies of oral human papillomavirus infection and head and neck squamous cell carcinoma, and it will discuss the implications for prevention and treatment.

Micro-ribonucleic acids in head and neck cancer: an introduction

2013 ◽  
Vol 127 (S2) ◽  
pp. S2-S7 ◽  
Author(s):  
I Gunawardena ◽  
J Fitzgerald ◽  
A Morley ◽  
D J Hussey ◽  
C M Woods ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Potential Role ◽  
Regulation Of Gene Expression ◽  
Head And Neck Oncology ◽  
Ribonucleic Acids ◽  
Non Coding Rnas ◽  
Cycle Regulation

AbstractBackground and methods:Head and neck cancer is the sixth most common cancer worldwide. Advances in management have not greatly altered overall survival. Over the last decade, there have been significant scientific advances in our knowledge of cell cycle regulation and the complex oncogenic processes. MicroRNAs are small, non-coding RNAs which are integral to the regulation of gene expression and which play a part in carcinogenesis. The literature on the role of microRNA in head and neck cancer is reviewed.Objective:To introduce the role and significance of microRNAs in head and neck cancer.Results:The possibilities of incorporating microRNAs into clinical practice are discussed, including their potential role in diagnosis, prognosis, prediction of metastatic spread, therapy and tumour surveillance.Conclusion:Discoveries in expression profiling of microRNA in head and neck oncology promise advancements in the diagnosis, prognosis and therapy of these cancers.

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