Significance of mammalian target of rapamycin in patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil

Head & Neck ◽  
2015 ◽  
Vol 38 (S1) ◽  
pp. E844-E852 ◽  
Author(s):  
Shau-Hsuan Li ◽  
Wei-Che Lin ◽  
Tai-Lin Huang ◽  
Chang-Han Chen ◽  
Tai-Jan Chiu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Mammalian Target Of Rapamycin ◽  
Stage Iv ◽  
Neck Squamous Cell Carcinoma ◽  
Advanced Stage

scholarly journals Concurrent Chemoradiation with Low-Dose Weekly Cisplatin in Locally Advanced Stage IV Head and Neck Squamous Cell Carcinoma

2014 ◽  
Vol 47 (3) ◽  
pp. 441-447 ◽  
Author(s):  
Myoung Hee Kang ◽  
Jung Hun Kang ◽  
Haa-Na Song ◽  
Bae Kwon Jeong ◽  
Gyu Young Chai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Low Dose ◽  
Locally Advanced ◽  
Stage Iv ◽  
Neck Squamous Cell Carcinoma ◽  
Advanced Stage ◽  
Weekly Cisplatin

nab-Paclitaxel-based induction chemotherapy with or without cetuximab for locally advanced head and neck squamous cell carcinoma

Oral Oncology ◽  
2017 ◽  
Vol 72 ◽  
pp. 26-31 ◽  
Author(s):  
Douglas Adkins ◽  
Jessica Ley ◽  
Peter Oppelt ◽  
Tanya M. Wildes ◽  
Hiram A. Gay ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Neck Squamous Cell Carcinoma ◽  
Advanced Head

Induction chemotherapy in locally advanced head-and-neck squamous cell carcinoma: Real-world outcome

2020 ◽  
Vol 4 (3) ◽  
pp. 105
Author(s):  
Manikandan Dhanushkodi ◽  
Vijay Gnanaguru ◽  
Venkatraman Radhakrishnan ◽  
JayachandranPerumal Kalaiarasi ◽  
ArunKumar Rajan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Squamous Cell ◽  
Real World ◽  
Locally Advanced ◽  
Neck Squamous Cell Carcinoma ◽  
Advanced Head

scholarly journals Induction Chemotherapy in Head and Neck Squamous Cell Carcinoma: A Question of Belief

Cancers ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 15 ◽  
Author(s):  
Andy Karabajakian ◽  
Max Gau ◽  
Thibault Reverdy ◽  
Eve-Marie Neidhardt ◽  
Jérôme Fayette
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Standard Of Care ◽  
Neck Squamous Cell Carcinoma ◽  
Larynx Preservation ◽  
Distant Failure

Induction chemotherapy (IC) in locally advanced head and neck squamous cell carcinoma (LA HNSCC) has been used for decades. However, its role is yet to be clearly defined outside of larynx preservation. Patients with high risk of distant failure might potentially benefit from sequential treatment. It is now widely accepted that TPF (docetaxel, cisplatin, and fluorouracil) is the standard IC regimen. Essays that have compared this approach with the standard of care, concurrent chemoradiotherapy (CCRT), are mostly inconclusive. Radiotherapy (RT) can be used in the post-IC setting and be sensitized by chemotherapy or cetuximab. Again, no consensus exists but there seems to be trend in favor of potentiation by cisplatin. Less toxic schemes of IC are tested as toxicity is a major issue with TPF. IC might have an interesting role in human papilloma virus (HPV)-related LA HNSCC and lead to CCRT de-escalation.

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