Use of radioiodine-131 scan to measure influence of surgical discipline, practice, and volume on residual thyroid tissue after total thyroidectomy for differentiated thyroid carcinoma

Head & Neck ◽  
2018 ◽  
Vol 40 (10) ◽  
pp. 2129-2136 ◽  
Author(s):  
Jin Soo A. Song ◽  
Nico Moolman ◽  
Steven Burrell ◽  
Murali Rajaraman ◽  
Martin Joseph Bullock ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Thyroid Tissue ◽  
Differentiated Thyroid Carcinoma

scholarly journals Assessment of calcium homeostasis after total thyroidectomy in differentiated thyroid carcinoma

2017 ◽  
Vol 5 (2) ◽  
pp. 79
Author(s):  
NareshK Panda ◽  
Gyanaranjan Nayak ◽  
RoshanK Verma ◽  
Jaimanti Bakshi ◽  
Abhijeet Singh ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Calcium Homeostasis ◽  
Differentiated Thyroid Carcinoma

scholarly journals Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 262
Author(s):  
Su Woong Yoo ◽  
Md. Sunny Anam Chowdhury ◽  
Subin Jeon ◽  
Sae-Ryung Kang ◽  
Sang-Geon Cho ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Thyroid Tissue ◽  
Predictive Performance ◽  
Response Prediction ◽  
Differentiated Thyroid Carcinoma ◽  
Whole Body ◽  
Serum Thyroglobulin ◽  
Focal Uptake ◽  
Uptake Pattern ◽  
Iodine Scan

We investigated whether the performance of serum thyroglobulin (Tg) for response prediction could be improved based on the iodine uptake pattern on the post-therapeutic I-131 whole body scan (RxWBS) and the degree of thyroid tissue damage with radioactive iodine (RAI) therapy. A total of 319 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and RAI therapy were included. Based on the presence/absence of focal uptake at the anterior midline of the neck above the thyroidectomy bed on RxWBS, patients were classified into positive and negative uptake groups. Serum Tg was measured immediately before (D0Tg) and 7 days after RAI therapy (D7Tg). Patients were further categorized into favorable and unfavorable Tg groups based on the prediction of excellent response (ER) using scan-corrected Tg developed through the stepwise combination of D0Tg with ratio Tg (D7Tg/D0Tg). We investigated whether the predictive performance for ER improved with the application of scan-corrected Tg compared to the single Tg cutoff. The combined approach using scan-corrected Tg showed better predictive performance for ER than the single cutoff of D0Tg alone (p < 0.001). Therefore, scan-corrected Tg can be a promising biomarker to predict the therapeutic responses after RAI therapy.

Differences in long-term quality of life between hemithyroidectomy and total thyroidectomy in patients treated for low-risk differentiated thyroid carcinoma

Surgery ◽  
2020 ◽  
Vol 167 (1) ◽  
pp. 94-101 ◽  
Author(s):  
Pim J. Bongers ◽  
Caylee A. Greenberg ◽  
Ralph Hsiao ◽  
Marloes Vermeer ◽  
Menno R. Vriens ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Differentiated Thyroid Carcinoma ◽  
Low Risk

scholarly journals Recombinant Human Thyrotropin-Aided Radioiodine Therapy in Patients with Metastatic Differentiated Thyroid Carcinoma

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Ivana Zagar ◽  
Andreja A. Schwarzbartl-Pevec ◽  
Barbara Vidergar-Kralj ◽  
Rika Horvat ◽  
Nikola Besic
Keyword(s):  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Physical Condition ◽  
Radioiodine Therapy ◽  
Differentiated Thyroid Carcinoma ◽  
Therapeutic Benefit ◽  
The Poor ◽  
Radioiodine Ablation ◽  
Recombinant Human Thyrotropin ◽  
Tsh Stimulation

Our aim was to test the efficacy of 131-I therapy (RIT) using recombinant human TSH (rhTSH) in patients with differentiated thyroid carcinoma (DTC) in whom endogenous TSH stimulation was not an option due to the poor patient's physical condition or due to the disease progression during L-thyroxin withdrawal. The study comprised 18 patients, who already have undergone total or near-total thyroidectomy and radioiodine ablation and 0–12 (median 5) RITs after L-thyroxin withdrawal. Our patients received altogether 44 RITs using rhTSH while on L-thyroxin. Six to 12 months after the first rhTSH-aided RIT, PR and SD was achieved in 3/18 (17%) and 4/18 patients (22%), respectively. In most patients (n= 12; 61%) disease progressed despite rhTSH-aided RITs. As a conclusion, rhTSH-aided RIT proved to add some therapeutic benefit in 39% our patients with metastatic DTC, who otherwise could not be efficiently treated with RIT.

SUPPRESSION OF THE TSH RESPONSE TO TRH BY THYROXINE THERAPY IN DIFFERENTIATED THYROID CARCINOMA PATIENTS

1979 ◽  
Vol 91 (2) ◽  
pp. 248-256 ◽  
Author(s):  
B.-A. Lamberg ◽  
Marja Rantanen ◽  
Pirkko Saarinen ◽  
K. Liewendahl ◽  
A. Sivula
Keyword(s):  
Thyroid Carcinoma ◽  
Thyroid Tissue ◽  
Reference Interval ◽  
Differentiated Thyroid Carcinoma ◽  
Thyrotrophin Releasing Hormone ◽  
Thyroxine Therapy ◽  
Trh Stimulation ◽  
Tsh Secretion ◽  
Adequate Dosage ◽  
The Individual

ABSTRACT Absent response of serum thyrotrophin (TSH) after stimulation with 200 μg synthetic thyrotrophin-releasing hormone (TRH) was used as a criterion of adequate suppression of TSH secretion in the treatment of thyroid carcinoma patients with thyroxine. The mean causing total suppression of the response was 223 μg of thyroxine per day. At this dose level about 40 % of the patients had serum thyroxine concentrations above the upper reference interval and only 10 % had elevated triiodothyronine concentrations. In some patients the TSH response to TRH varied between absent and low normal when tested at long intervals. The ideal dose of thyroxine is obviously slightly higher than the smallest one causing total suppression of the TSH response to TRH, i.e. about 250 μg a day. The individual dose must be found using the TRH stimulation test because serum thyroid hormone levels cannot be used as a guideline for adequate dosage. In some patients the thyroid remnant of apparently normal thyroid tissue was not totally suppressed although the thyroxine dose was definitely above the level causing suppression of the response to TRH.

scholarly journals Pediatric Differentiated Thyroid Carcinoma: Outcome in Response to Initial Treatment

2019 ◽  
Vol 24 (2) ◽  
pp. 143-148
Author(s):  
Md Mosleh Uddin ◽  
Syed Farhan Ali Razib ◽  
Kazi Shameemus Salam ◽  
Mohd Abdus Sattar ◽  
Belayat Hossain Siddiquee
Keyword(s):  
Adverse Effects ◽  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Initial Treatment ◽  
Differentiated Thyroid Carcinoma ◽  
Good Prognosis ◽  
Imaging Studies ◽  
Patients Experience ◽  
Longterm Outcome

Introduction: Though the differentiated thyroid carcinoma in children is a common pediatric endocrine malignancy, its prognosis is excellent with a proper initial treatment. Objectives: This is to evaluate the initial treatment patern for a good prognosis with longterm outcome in pediatric DTC patients. Methods: This study is a prospective one done in BSMMU during a period of 10 years in 52 post-operative pediatric DTC patients after excluding the follow-up missing patients. These patients are yet in a regular follow-up were outcome evaluated with clinical, pathological & imaging studies. Results: All the patients got initial treatment of total thyroidectomy. About half of the group had undergone neck dissection along with total thyroidectomy. Forty six patients had taken 131-I therapy. The survival is 100%. Conclusion: The life expectancy for children with DTC is excellent. However, many patients experience adverse effects from thyroid surgery, resulting in life long complications.  Bangladesh J of Otorhinolaryngology; October 2018; 24(2): 143-148

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