Role of PET/CT in detection of post-Thyroidectomy recurrence in differentiated cancer thyroid patients with negative radio-isotope iodine scan & elevated serum thyroglobulin level

Aim of the Work To study of the role of PET/CT in in detection of post-thyroidectomy recurrence in differentiated cancer thyroid patients having negative radio-isotope iodine scan & high serum thyroglobulin level. Materials and Methods The study incorporated 20 patients with previous history of differentiated cancer thyroid. All patients performed Serum Thyroglobulin level Estimation & entire body scan I-131 (WBS) examination & PET/CT study alluded from oncology specialist to Radiology Department. All patients in the study were subjected to history taking &revising the medical sheet. Results PET/CT results will be compared with iodine radio-isotope scan & serum thyroglobulin level and statistical analysis of the collected data will be performed to determine the diagnostic value of the PET/CT in detection of local recurrence or distant metastasis.

Papillary carcinoma in a thyroglossal cyst: a rare case report and review of literature

Thyroglossal cysts are the most common thyroid anomaly with a majority of it being diagnosed at fourth decade of life. Authors report a case of 32-year-old lady with a globular swelling of 3×2 cm moving with deglutition with no cervical lymph nodes and a normal thyroid function test. Intra operatively a distinct lesion of 3×2 cm was found superior to the thyroid gland with firm nodules in the right lobe of the thyroid. Patient underwent total thyroidectomy with central compartment neck dissection and Sistrunk’s operation followed by a negative radio iodine scan and thyroid hormone suppression. This was considered based on intraoperative nodularity of the thyroid gland.

Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma

We investigated whether the performance of serum thyroglobulin (Tg) for response prediction could be improved based on the iodine uptake pattern on the post-therapeutic I-131 whole body scan (RxWBS) and the degree of thyroid tissue damage with radioactive iodine (RAI) therapy. A total of 319 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and RAI therapy were included. Based on the presence/absence of focal uptake at the anterior midline of the neck above the thyroidectomy bed on RxWBS, patients were classified into positive and negative uptake groups. Serum Tg was measured immediately before (D0Tg) and 7 days after RAI therapy (D7Tg). Patients were further categorized into favorable and unfavorable Tg groups based on the prediction of excellent response (ER) using scan-corrected Tg developed through the stepwise combination of D0Tg with ratio Tg (D7Tg/D0Tg). We investigated whether the predictive performance for ER improved with the application of scan-corrected Tg compared to the single Tg cutoff. The combined approach using scan-corrected Tg showed better predictive performance for ER than the single cutoff of D0Tg alone (p < 0.001). Therefore, scan-corrected Tg can be a promising biomarker to predict the therapeutic responses after RAI therapy.