Outcomes of relapsed human papillomavirus‐related oropharyngeal squamous cell carcinoma treated with curative intent

Head & Neck ◽  
2018 ◽  
Vol 41 (5) ◽  
pp. 1312-1319 ◽  
Author(s):  
Patrik Pipkorn ◽  
Parul Sinha ◽  
Dorina Kallogjeri ◽  
Douglas Adkins ◽  
Wade T. Thorstad ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Curative Intent

Pre-treatment absolute lymphocyte count predicts for improved survival in human papillomavirus (HPV)-driven oropharyngeal squamous cell carcinoma

Oral Oncology ◽  
2021 ◽  
Vol 116 ◽  
pp. 105245
Author(s):  
P.J. Kreinbrink ◽  
J. Li ◽  
S. Parajuli ◽  
T.M. Wise-Draper ◽  
D.L. Choi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphocyte Count ◽  
Absolute Lymphocyte Count ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Pre Treatment

Transoral robotic surgery for oropharyngeal squamous cell carcinoma in the era of human papillomavirus

Head & Neck ◽  
2017 ◽  
Vol 40 (4) ◽  
pp. 710-721 ◽  
Author(s):  
Omar Mahmoud ◽  
Kim Sung ◽  
Francisco J. Civantos ◽  
Giovanna R. Thomas ◽  
Michael A. Samuels
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Robotic Surgery ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Transoral Robotic Surgery ◽  
Oropharyngeal Squamous Cell Carcinoma

Treatment trends for advanced oropharyngeal squamous cell carcinoma in the era of human papillomavirus

Head & Neck ◽  
2021 ◽  
Author(s):  
Faris A. Mirza ◽  
Christopher Z. Johnson ◽  
James Kenneth Byrd ◽  
William Greer Albergotti
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Treatment Trends

Survival Outcomes for p16-positive Oropharyngeal Squamous Cell Carcinoma Based on Human Papillomavirus Status

2021 ◽  
Author(s):  
S.D. Robinson ◽  
J.D. Towler ◽  
R. Kitson ◽  
D. Saleh ◽  
H.-C. Younan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Survival Outcomes

Impact of Human Papillomavirus on the Tumor Microenvironment in Oropharyngeal Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Xinyi Liu ◽  
Ping Liu ◽  
Rebecca D. Chernock ◽  
Krystle A. Lang Kuhs ◽  
James S. Lewis ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Tumor Microenvironment ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma

Salivary HPV Persistence Following Treatment of Oropharyngeal Squamous Cell Carcinoma

2021 ◽  
pp. 000348942110556
Author(s):  
Alexandra E. Quimby ◽  
Pagona Lagiou ◽  
Bibiana Purgina ◽  
Martin Corsten ◽  
Stephanie Johnson-Obaseki
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hpv Infection ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Cancer Center ◽  
Study Cohort ◽  
Curative Intent ◽  
Cross Sectional ◽  
Hpv Dna

Objective: To determine the persistence of human papillomavirus (HPV) infection following treatment of HPV-positive oropharyngeal squamous cell carcinoma (HPV + OPSCC). Methods: A cross-sectional study was undertaken at The Ottawa Hospital (Ottawa, ON, Canada), a tertiary academic hospital and regional cancer center. Adult patients who were diagnosed with HPV + OPSCC between the years of 2014 and 2016 and treated with curative intent, and who were alive and willing to consent were eligible for inclusion. A saliva assay was used to test for the presence of HPV DNA in a random sample of patients. qPCR was used to amplify DNA from saliva samples. Results: Saliva samples were obtained from 69 patients previously treated with HPV + OPSCC. All patients had a minimum of 2 years of follow-up. 5 patients tested positive for HPV: 2 were positive for HPV-16, 2 for HPV-18, and 1 “other” HPV type. No patient in our study cohort had suffered recurrence post-treatment. Conclusions: This study is the first to demonstrate the prevalence of persistent oncogenic HPV DNA in saliva following treatment for HPV + OPSCC. This prevalence appears to be low, despite the fact that persistent HPV infection is a precursor for the development of HPV + OPSCC. This finding raises questions about what factors influence the clearance or persistence of HPV DNA in saliva after treatment for HPV + OPSCC, and may add to our understanding about the longitudinal effects of HPV infection in these cancers.

Current status of human papillomavirus positivity in oropharyngeal squamous cell carcinoma in Europe: a systematic review

2019 ◽  
Vol 139 (12) ◽  
pp. 1112-1116 ◽  
Author(s):  
Karoline Dyrberg Stjernstrøm ◽  
Jakob Schmidt Jensen ◽  
Kathrine Kronberg Jakobsen ◽  
Christian Grønhøj ◽  
Christian von Buchwald
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Current Status

scholarly journals Raptor and rictor expression in patients with human papillomavirus-related oropharyngeal squamous cell carcinoma

2020 ◽  
Author(s):  
Shunsuke Kondo ◽  
Hitoshi Hirakawa ◽  
Taro Ikegami ◽  
Takayuki Uehara ◽  
Shinya Agena ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Squamous Cell ◽  
Mtor Pathway ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
High Gene ◽  
Complex Expression

Abstract Background Despite reports of a link between human papillomavirus (HPV) infection and mechanistic target of rapamycin (mTOR) signaling activation, the role of the mTOR pathway, especially raptor and rictor, in HPV-related head and neck cancer is still unclear. The aim of the present study was to elucidate the role of the mTOR pathway in HPV-related oropharyngeal squamous cell carcinoma (OPSCC). Methods The present study involved two strategies. The first was to investigate the activity of mTOR and mTOR-related complexes in high-risk HPV-positive (UM-SCC47 and CaSki) and HPV-negative (SCC-4 and SAS) cancer cell lines. The second was to elucidate mTOR complex expression in 80 oropharyngeal cancer tissues and to examine the relationship between mTOR complex expression and survival in patients with OPSCC. Results The UM-SCC47 and CaSki cell lines showed high gene and protein expression of raptor. They also exhibited G1/S and G2/M phase cell cycle arrest following 24 h incubation with 6 μM temsirolimus, a rapamycin analog, and temsirolimus administration inhibited their growth. HPV-related OPSCC samples showed high gene expression of raptor and rictor compared with HPV-unrelated OPSCC. In addition, HPV-related OPSCC patients with high raptor and rictor expression tended to have a worse prognosis than those with low or medium expression. Conclusions These results suggest that raptor has an important role in HPV-related OPSCC and that temsirolimus is a potential therapeutic agent for patients with HPV-related OPSCC. This is the first report to reveal overexpression of raptor and rictor in HPV-related OPSCC.

scholarly journals Prognostic Value of Radiologic Extranodal Extension in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma

2019 ◽  
Vol 20 (8) ◽  
pp. 1266 ◽  
Author(s):  
Boeun Lee ◽  
Young Jun Choi ◽  
Seon-Ok Kim ◽  
Yoon Se Lee ◽  
Jung Yong Hong ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Extranodal Extension
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