Surgical treatment of early-stage carcinoma of the oral tongue—would adjuvant treatment be beneficial?

1986 ◽  
Vol 8 (6) ◽  
pp. 401-408 ◽  
Author(s):  
Christopher J. O'brien ◽  
Christopher J. Lahr ◽  
Seng-Jaw Soong ◽  
Michael J. Gandour ◽  
J. Michael Jones ◽  
...  
2016 ◽  
Author(s):  
Adarsh Dharmarajan ◽  
M. Geetha

Introduction: Clinical staging is universally accepted for ca cervix. In early stage of carcinoma cervix both radiation and radical hysterectomy given equivalent local control rates as well as survival. Poor prognostic factors following surgery would necessitate-post-operative adjuvant radiation. Selecting the patients who is unlikely to require adjuvant treatment after surgery spares them the toxicity of multiple treatment modalities, which is worse than alone. Aim: To find out clinico-pathological correlation in early stage carcinoma cervix treated with the surgery. Materials and Methods: It is a retrospective audit of study. All carcinoma cervix cases primarily treated with surgery. Results: A total of 25 cases were treated in this study. The median age of patients observed with 48 years. The common symptoms and stage were vaginal discharge (i.e., 42.30%) and 1B1 (61.53%). Most of patients were treated with type III radical hysterectomy and their clinical staging was correlated with the final histo-pathological staging. A total of 11 (i.e., 42.30%) required adjuvant treatment among them 7 (63.633%), 1 (9.09%) and 3 (27.27%) patients were in 1B1 1B2 and 2A respectively. The chi-square test has been performed to compute the correlation between clinical and histo-pathological finding. It shows that significant amount of relation present between clinical and histo-pathological findings.


Toukeibu Gan ◽  
2017 ◽  
Vol 43 (1) ◽  
pp. 17-22
Author(s):  
Rintaro Shimazu ◽  
Mihoko Yamamoto ◽  
Akimichi Minesaki ◽  
Eriko Shimazaki ◽  
Yuichiro Kuratomi

Oral Oncology ◽  
2000 ◽  
Vol 36 (6) ◽  
pp. 508-514 ◽  
Author(s):  
N. Al-Rajhi ◽  
Y. Khafaga ◽  
J. El-Husseiny ◽  
M. Saleem ◽  
W. Mourad ◽  
...  

2017 ◽  
Vol 4 (1) ◽  
pp. 36
Author(s):  
Kashyap Rahul ◽  
Siwach Vijay ◽  
Kumar Jitender ◽  
Arya Varun ◽  
Anil K Sheorain ◽  
...  

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3235
Author(s):  
Alhadi Almangush ◽  
Ibrahim O. Bello ◽  
Ilkka Heikkinen ◽  
Jaana Hagström ◽  
Caj Haglund ◽  
...  

Although patients with early-stage oral tongue squamous cell carcinoma (OTSCC) show better survival than those with advanced disease, there is still a number of early-stage cases who will suffer from recurrence, cancer-related mortality and worse overall survival. Incorporation of an immune descriptive factor in the staging system can aid in improving risk assessment of early OTSCC. A total of 290 cases of early-stage OTSCC re-classified according to the American Joint Committee on Cancer (AJCC 8) staging were included in this study. Scores of tumor-infiltrating lymphocytes (TILs) were divided as low or high and incorporated in TNM AJCC 8 to form our proposed TNM-Immune system. Using AJCC 8, there were no significant differences in survival between T1 and T2 tumors (p > 0.05). Our proposed TNM-Immune staging system allowed for significant discrimination in risk between tumors of T1N0M0-Immune vs. T2N0M0-Immune. The latter associated with a worse overall survival with hazard ratio (HR) of 2.87 (95% CI 1.92–4.28; p < 0.001); HR of 2.41 (95% CI 1.26–4.60; p = 0.008) for disease-specific survival; and HR of 1.97 (95% CI 1.13–3.43; p = 0.017) for disease-free survival. The TNM-Immune staging system showed a powerful ability to identify cases with worse survival. The immune response is an important player which can be assessed by evaluating TILs, and it can be implemented in the staging criteria of early OTSCC. TNM-Immune staging forms a step towards a more personalized classification of early OTSCC.


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