scholarly journals Genome‐wide association of individual vulnerability with alcoholic liver disease: A Korean Genome and Epidemiology Study

Hepatology ◽  
2021 ◽  
Author(s):  
Kwang Yoon Kim ◽  
Jung Oh Kim ◽  
Young‐Sang Kim ◽  
Ja‐Eun Choi ◽  
Jae‐Min Park ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Genome Wide Association ◽  
Epidemiology Study ◽  
Individual Vulnerability ◽  
Genome Wide

scholarly journals Genome-Wide Association Studies and Liver Disease

2015 ◽  
Vol 35 (04) ◽  
pp. 355-360
Author(s):  
Elizabeth Speliotes
Keyword(s):  
Liver Disease ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide

scholarly journals A genome-wide association study for nonalcoholic fatty liver disease identifies novel genetic loci and trait-relevant candidate genes in the Million Veteran Program

2021 ◽  
Author(s):  
Marijana Vujkovic ◽  
Shweta Ramdas ◽  
Kimberly M. Lorenz ◽  
Carolin V. Schneider ◽  
Joseph Park ◽  
...  
Keyword(s):  
Gene Expression ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Functional Genomic ◽  
Nonalcoholic Fatty Liver ◽  
Genomic Annotation ◽  
Genome Wide

AbstractNonalcoholic fatty liver disease (NAFLD) is a prevalent, heritable trait that can progress to cancer and liver failure. Using our recently developed proxy definition for NAFLD based on chronic liver enzyme elevation without other causes of liver disease or alcohol misuse, we performed a multi-ancestry genome-wide association study in the Million Veteran Program with 90,408 NAFLD cases and 128,187 controls. Seventy-seven loci exceeded genome-wide significance of which 70 were novel, with an additional European-American specific and two African-American specific loci. Twelve of these loci were also significantly associated with quantitative hepatic fat on radiological imaging (n=44,289). Gene prioritization based on coding annotations, gene expression from GTEx, and functional genomic annotation identified candidate genes at 97% of loci. At eight loci, the allele associated with lower gene expression in liver was also associated with reduced risk of NAFLD, suggesting potential therapeutic relevance. Functional genomic annotation and gene-set enrichment demonstrated that associated loci were relevant to liver biology. We expand the catalog of genes influencing NAFLD, and provide a novel resource to understand its disease initiation, progression and therapy.

scholarly journals A genome-wide association study identified genetic loci for end-stage liver disease in the Korean population

2020 ◽  
Vol 34 (1) ◽  
pp. S146-S146
Author(s):  
Hye-Mi Jang ◽  
Dong Jin Joo ◽  
Sung Min Kim ◽  
Hyun-Young Park ◽  
Bong-Jo Kim ◽  
...  
Keyword(s):  
Liver Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Korean Population ◽  
Genetic Loci ◽  
End Stage Liver Disease ◽  
Genome Wide ◽  
A Genome ◽  
End Stage

scholarly journals Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

PLoS Genetics ◽  
2011 ◽  
Vol 7 (3) ◽  
pp. e1001324 ◽  
Author(s):  
Elizabeth K. Speliotes ◽  
Laura M. Yerges-Armstrong ◽  
Jun Wu ◽  
Ruben Hernaez ◽  
Lauren J. Kim ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Association Analysis ◽  
Fatty Liver Disease ◽  
Genome Wide Association ◽  
Nonalcoholic Fatty Liver ◽  
Genome Wide Association Analysis ◽  
Metabolic Traits ◽  
Genome Wide

scholarly journals Insights from Genome-Wide Association Analyses of Nonalcoholic Fatty Liver Disease

2015 ◽  
Vol 35 (04) ◽  
pp. 375-391 ◽  
Author(s):  
Bratati Kahali ◽  
Brian Halligan ◽  
Elizabeth Speliotes
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Genome Wide Association ◽  
Nonalcoholic Fatty Liver ◽  
Association Analyses ◽  
Genome Wide

scholarly journals Genome‐Wide Association Study of Lean Nonalcoholic Fatty Liver Disease Suggests Human Leukocyte Antigen as a Novel Candidate Locus

2020 ◽  
Vol 4 (8) ◽  
pp. 1124-1135
Author(s):  
Ken Yoshida ◽  
Kazuha Yokota ◽  
Yukinobu Kutsuwada ◽  
Kazuhiro Nakayama ◽  
Kazuhisa Watanabe ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Genome Wide Association Study ◽  
Human Leukocyte ◽  
Genome Wide Association ◽  
Candidate Locus ◽  
Nonalcoholic Fatty Liver ◽  
Leukocyte Antigen ◽  
Genome Wide
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