Low-frequency stimulation induces a new form of LTP, metabotropic glutamate (mGlu5) receptor- and PKA-dependent, in the CA1 area of the rat hippocampus

Hippocampus ◽  
2006 ◽  
Vol 16 (4) ◽  
pp. 345-360 ◽  
Author(s):  
Fabien Lanté ◽  
Marie-Céleste de Jésus Ferreira ◽  
Janique Guiramand ◽  
Max Récasens ◽  
Michel Vignes
Keyword(s):  
Low Frequency ◽  
Rat Hippocampus ◽  
Metabotropic Glutamate ◽  
Mglu5 Receptor ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation ◽  
New Form ◽  
Ca1 Area

scholarly journals A Comparison of the Dynamics of S100B, S100A1, and S100A6 mRNA Expression in Hippocampal CA1 Area of Rats during Long-Term Potentiation and after Low-Frequency Stimulation

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Pavel D. Lisachev ◽  
Mark B. Shtark ◽  
Olga O. Sokolova ◽  
Vladimir O. Pustylnyak ◽  
Mary Yu. Salakhutdinova ◽  
...  
Keyword(s):  
Mrna Level ◽  
Hippocampal Slices ◽  
Low Frequency ◽  
Fold Increase ◽  
Long Term Potentiation ◽  
Low Frequency Stimulation ◽  
Term Potentiation ◽  
Mrna Content ◽  
Frequency Stimulation ◽  
Ca1 Area

The interest in tissue- and cell-specific S100 proteins physiological roles in the brain remains high. However, necessary experimental data for the assessment of their dynamics in one of the most important brain activities, its plasticity, is not sufficient. We studied the expression of S100B, S100A1, and S100A6 mRNA in the subfield CA1 of rat hippocampal slices after tetanic and low-frequency stimulation by real-time PCR. Within 30 min after tetanization, a 2–4 fold increase of the S100B mRNA level was observed as compared to the control (intact slices) or to low-frequency stimulation. Subsequently, the S100B mRNA content gradually returned to baseline. The amount of S100A1 mRNA gradually increased during first hour and maintained at the achieved level in the course of second hour after tetanization. The level of S100A6 mRNA did not change following tetanization or low-frequency stimulation.

Cancellation of low-frequency stimulation-induced long-term depression by docosahexaenoic acid in the rat hippocampus

1998 ◽  
Vol 247 (2-3) ◽  
pp. 198-200 ◽  
Author(s):  
Chainllie Young ◽  
Po-Wu Gean ◽  
Shang-Peng Wu ◽  
Chih-Hung Lin ◽  
Yu-Zen Shen
Keyword(s):  
Docosahexaenoic Acid ◽  
Low Frequency ◽  
Rat Hippocampus ◽  
Long Term Depression ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation

scholarly journals Low-Frequency Stimulation Prevents Kindling-Induced Impairment through the Activation of the Endocannabinoid System

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Sina Khajei ◽  
Khadijeh Esmaeilpour ◽  
Javad Mirnajafi-Zadeh ◽  
Vahid Sheibani ◽  
Soheila Rezakhani ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Low Frequency ◽  
Endocannabinoid System ◽  
The Novel ◽  
Memory Impairments ◽  
Low Frequency Stimulation ◽  
Hippocampal Ca1 ◽  
Significant Difference ◽  
Frequency Stimulation ◽  
Ca1 Area

Background. Cannabinoid system affects memory and has anticonvulsant effects in epileptic models. In the current study, the role of cannabinoid 1 (CB1) receptors was investigated in amelioration of the effects of low-frequency stimulation (LFS) on learning and memory impairments in kindled rats. Methods. Electrical stimulation of the hippocampal CA1 area was employed to kindle the animals. LFS was applied to the CA1 area in four trials following the last kindling stimulation. One group of animals received intraperitoneal injection of AM251 (0.1 μg/rat), a CB1 receptor antagonist, before the LFS application. Similarly, CB1 agonist WIN55-212-2 (WIN) was administrated to another group prior to LFS. The Morris water maze (MWM) and the novel object recognition (NOR) tests were executed 48 h after the last kindling stimulation to assess learning and memory. Results. Applying LFS in the kindled+LFS group restored learning and memory impairments in the kindled rats. There was a significant difference between the kindled and the kindled+LFS groups in learning and memory. The application of AM251 reduced the LFS effects significantly. Adversely, WIN acted similarly to LFS and alleviated learning and memory deficits in the kindled+WIN group. In addition, WIN did not counteract the LFS enhancing effects in the KLFS+WIN group. Conclusions. Improving effects of LFS on learning and memory impairments are mediated through the activation of the endocannabinoid (ECB) system.

scholarly journals Low-frequency Stimulation at the Subiculum is Anti-convulsant and Anti-drug-resistant in a Mouse Model of Lamotrigine-resistant Temporal Lobe Epilepsy

2020 ◽  
Vol 36 (6) ◽  
pp. 654-658
Author(s):  
Yeping Ruan ◽  
Cenglin Xu ◽  
Jile Lan ◽  
Jiazhen Nao ◽  
Shuo Zhang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Low Frequency ◽  
Drug Resistant ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation

Fatigue and damage to the masseter muscle by prolonged low-frequency stimulation in the rat

2005 ◽  
Vol 50 (12) ◽  
pp. 1005-1013 ◽  
Author(s):  
Konosuke Yamasaki ◽  
Shuitsu Harada ◽  
Itsuro Higuchi ◽  
Mitsuhiro Osame ◽  
Gakuji Ito
Keyword(s):  
Masseter Muscle ◽  
Low Frequency ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation

scholarly journals MONOSYNAPTIC REFLEX RESPONSE OF INDIVIDUAL MOTONEURONS AS A FUNCTION OF FREQUENCY

1957 ◽  
Vol 40 (3) ◽  
pp. 435-450 ◽  
Author(s):  
David P. C. Lloyd
Keyword(s):  
High Frequency ◽  
Temporal Summation ◽  
Low Frequency ◽  
Stimulation Frequency ◽  
Monosynaptic Reflex ◽  
Reflex Response ◽  
High Frequency Stimulation ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation ◽  
Frequency Of Stimulation

An assemblage of individual motoneurons constituting a synthetic motoneuron pool has been studied from the standpoint of relating monosynaptic reflex responses to frequency of afferent stimulation. Intensity of low frequency depression is not a simple function of transmitter potentiality. As frequency of stimulation increases from 3 per minute to 10 per second, low frequency depression increases in magnitude. Between 10 and approximately 60 per second low frequency depression apparently diminishes and subnormality becomes a factor in causing depression. At frequencies above 60 per second temporal summation occurs, but subnormality limits the degree of response attainable by summation. At low stimulation frequencies rhythm is determined by stimulation frequency. Interruptions of rhythmic firing depend solely upon temporal fluctuation of excitability. At high frequency of stimulation rhythm is determined by subnormality rather than inherent rhythmicity, and excitability fluctuation leads to instability of response rhythm. In short, whatever the stimulation frequency, random excitability fluctuation is the factor disrupting rhythmic response. Monosynaptic reflex response latency is stable during high frequency stimulation as it is in low frequency stimulation provided a significant extrinsic source of random bombardment is not present. In the presence of powerful random bombardment discharge may become random with respect to monosynaptic afferent excitation provided the latter is feeble. When this occurs it does so equally at low frequency and high frequency. Thus temporal summation is not a necessary factor. There is, then, no remaining evidence to suggest that the agency for temporal summation in the monosynaptic system becomes a transmitting agency in its own right.

Effects of low-frequency stimulation of the superior colliculus on spontaneous and visually guided saccades

1993 ◽  
Vol 69 (3) ◽  
pp. 953-964 ◽  
Author(s):  
P. W. Glimcher ◽  
D. L. Sparks
Keyword(s):  
Superior Colliculus ◽  
Time Course ◽  
Low Frequency ◽  
Arbitrary Point ◽  
Visually Guided ◽  
Spontaneous Movements ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation ◽  
Stimulation Current ◽  
Stimulation Of

1. The first experiment of this study determined the effects of low-frequency stimulation of the monkey superior colliculus on spontaneous saccades in the dark. Stimulation trains, subthreshold for eliciting short-latency fixed-vector saccades, were highly effective at biasing the metrics (direction and amplitude) of spontaneous movements. During low-frequency stimulation, the distribution of saccade metrics was biased toward the direction and amplitude of movements induced by suprathreshold stimulation of the same collicular location. 2. Low-frequency stimulation biased the distribution of saccade metrics but did not initiate movements. The distribution of intervals between stimulation onset and the onset of the next saccade did not differ significantly from the distribution of intervals between an arbitrary point in time and the onset of the next saccade under unstimulated conditions. 3. Results of our second experiment indicate that low-frequency stimulation also influenced the metrics of visually guided saccades. The magnitude of the stimulation-induced bias increased as stimulation current or frequency was increased. 4. The time course of these effects was analyzed by terminating stimulation immediately before, during, or after visually guided saccades. Stimulation trains terminated at the onset of a movement were as effective as stimulation trains that continued throughout the movement. No effects were observed if stimulation ended 40–60 ms before the movement began. 5. These results show that low-frequency collicular stimulation can influence the direction and amplitude of spontaneous or visually guided saccades without initiating a movement. These data are compatible with the hypothesis that the collicular activity responsible for specifying the horizontal and vertical amplitude of a saccade differs from the type of collicular activity that initiates a saccade.

Low Frequency Stimulation (Quenching) Affects Amygdala Kindling-Induced Gene Expression in Rat Brain

2015 ◽  
Vol 8 (2) ◽  
pp. 414-415
Author(s):  
Guoqiang Xing ◽  
Susan Weiss ◽  
Robert Post
Keyword(s):  
Gene Expression ◽  
Rat Brain ◽  
Low Frequency ◽  
Low Frequency Stimulation ◽  
Amygdala Kindling ◽  
Frequency Stimulation
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