scholarly journals Low-Frequency Stimulation Prevents Kindling-Induced Impairment through the Activation of the Endocannabinoid System

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Sina Khajei ◽  
Khadijeh Esmaeilpour ◽  
Javad Mirnajafi-Zadeh ◽  
Vahid Sheibani ◽  
Soheila Rezakhani ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Low Frequency ◽  
Endocannabinoid System ◽  
The Novel ◽  
Memory Impairments ◽  
Low Frequency Stimulation ◽  
Hippocampal Ca1 ◽  
Significant Difference ◽  
Frequency Stimulation ◽  
Ca1 Area

Background. Cannabinoid system affects memory and has anticonvulsant effects in epileptic models. In the current study, the role of cannabinoid 1 (CB1) receptors was investigated in amelioration of the effects of low-frequency stimulation (LFS) on learning and memory impairments in kindled rats. Methods. Electrical stimulation of the hippocampal CA1 area was employed to kindle the animals. LFS was applied to the CA1 area in four trials following the last kindling stimulation. One group of animals received intraperitoneal injection of AM251 (0.1 μg/rat), a CB1 receptor antagonist, before the LFS application. Similarly, CB1 agonist WIN55-212-2 (WIN) was administrated to another group prior to LFS. The Morris water maze (MWM) and the novel object recognition (NOR) tests were executed 48 h after the last kindling stimulation to assess learning and memory. Results. Applying LFS in the kindled+LFS group restored learning and memory impairments in the kindled rats. There was a significant difference between the kindled and the kindled+LFS groups in learning and memory. The application of AM251 reduced the LFS effects significantly. Adversely, WIN acted similarly to LFS and alleviated learning and memory deficits in the kindled+WIN group. In addition, WIN did not counteract the LFS enhancing effects in the KLFS+WIN group. Conclusions. Improving effects of LFS on learning and memory impairments are mediated through the activation of the endocannabinoid (ECB) system.

scholarly journals Effects of Personal Low-Frequency Stimulation Device on Myalgia: A Randomized Controlled Trial

2022 ◽  
Vol 19 (2) ◽  
pp. 735
Author(s):  
Yong-Soon Yoon ◽  
Myoung-Hwan Ko ◽  
Il-Young Cho ◽  
Cheol-Su Kim ◽  
Johny Bajgai ◽  
...  
Keyword(s):  
Physical Therapy ◽  
Short Form ◽  
Therapy Group ◽  
Controlled Trial ◽  
Low Frequency ◽  
Control Group ◽  
Mcgill Pain Questionnaire ◽  
Low Frequency Stimulation ◽  
Significant Difference ◽  
Frequency Stimulation

Electrotherapy is commonly used for myalgia alleviation. Low-frequency stimulation (LFS) is primarily used for controlling acute and chronic pain and is a non-invasive therapy that can be easily performed with electric stimulation applied on the skin. However, little evidence exists regarding the pain alleviation effects of personal low-frequency stimulation device for home use. Moreover, no studies have compared myalgia alleviation effects between personal low-frequency stimulation (PLS) and physical therapy (PT), which are most commonly used for patients with myalgia in hospitals and clinics. Therefore, we aimed to investigate the pain alleviation effects of PLS in patients with myalgia and compare these effects with those of conventional PT (transcutaneous electrical nerve stimulation + ultrasound). In total, 39 patients with myalgia in the neck, shoulder, back, and waist areas were randomly assigned to the personal low-frequency stimulation group (PLSG: n = 20) and physical therapy group (PTG: n = 19). Both groups were treated for 3 weeks (20 min per session and 5 sessions per week). Patients were assessed for pain intensity by surface electromyography (sEMG), visual analogue scale (VAS) and a short-form McGill pain questionnaire (SF-MPQ) before and after the intervention period. Our results showed that PLSG showed a tendency of muscle relaxation with a significant decrease in sEMG in the neck (p = 0.0425), shoulder (p = 0.0425), and back (p = 0.0046) areas compared to the control group. However, there was no significant difference in waist area. Additionally, VAS scores significantly decreased between pre- and post-treatment in both PTG (p = 0.0098), and PLSG (p = 0.0304) groups, but there was no significance difference between the groups. With respect to SF-MPQ, the PLSG showed greater pain alleviation (5.23 ± 0.25) effects than the PTG (6.23 ± 0.25). Accordingly, our results suggest that PLS treatment using a home device might offer positive assistance in pain alleviation for patients with myalgia that is as equally effective as conventional PT treatment. However, further detailed studies are required considering larger samples to fully claim the effectiveness of this device.

scholarly journals A Comparison of the Dynamics of S100B, S100A1, and S100A6 mRNA Expression in Hippocampal CA1 Area of Rats during Long-Term Potentiation and after Low-Frequency Stimulation

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Pavel D. Lisachev ◽  
Mark B. Shtark ◽  
Olga O. Sokolova ◽  
Vladimir O. Pustylnyak ◽  
Mary Yu. Salakhutdinova ◽  
...  
Keyword(s):  
Mrna Level ◽  
Hippocampal Slices ◽  
Low Frequency ◽  
Fold Increase ◽  
Long Term Potentiation ◽  
Low Frequency Stimulation ◽  
Term Potentiation ◽  
Mrna Content ◽  
Frequency Stimulation ◽  
Ca1 Area

The interest in tissue- and cell-specific S100 proteins physiological roles in the brain remains high. However, necessary experimental data for the assessment of their dynamics in one of the most important brain activities, its plasticity, is not sufficient. We studied the expression of S100B, S100A1, and S100A6 mRNA in the subfield CA1 of rat hippocampal slices after tetanic and low-frequency stimulation by real-time PCR. Within 30 min after tetanization, a 2–4 fold increase of the S100B mRNA level was observed as compared to the control (intact slices) or to low-frequency stimulation. Subsequently, the S100B mRNA content gradually returned to baseline. The amount of S100A1 mRNA gradually increased during first hour and maintained at the achieved level in the course of second hour after tetanization. The level of S100A6 mRNA did not change following tetanization or low-frequency stimulation.

Low-frequency stimulation induces a new form of LTP, metabotropic glutamate (mGlu5) receptor- and PKA-dependent, in the CA1 area of the rat hippocampus

Hippocampus ◽  
2006 ◽  
Vol 16 (4) ◽  
pp. 345-360 ◽  
Author(s):  
Fabien Lanté ◽  
Marie-Céleste de Jésus Ferreira ◽  
Janique Guiramand ◽  
Max Récasens ◽  
Michel Vignes
Keyword(s):  
Low Frequency ◽  
Rat Hippocampus ◽  
Metabotropic Glutamate ◽  
Mglu5 Receptor ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation ◽  
New Form ◽  
Ca1 Area

Novel Form of LTD Induced by Transient, Partial Inhibition of the Na,K-Pump in Rat Hippocampal CA1 Cells

2004 ◽  
Vol 91 (1) ◽  
pp. 239-247 ◽  
Author(s):  
Christian G. Reich ◽  
Susanne E. Mason ◽  
Bradley E. Alger
Keyword(s):  
Hippocampal Slices ◽  
Low Frequency ◽  
Bk Channels ◽  
P38 Map Kinase ◽  
Partial Inhibition ◽  
Low Frequency Stimulation ◽  
Hippocampal Ca1 ◽  
Frequency Stimulation ◽  
Selective Blocker

We tested the hypothesis that transient, partial inhibition of the Na,K-pumps could produce lasting effects on synaptic efficacy in brain tissue by applying a low concentration of the ouabain analogue, dihydroouabain (DHO), to hippocampal slices for 15 min and studying the effects on field excitatory postsynaptic potentials (fEPSPs). DHO caused a suppression of fEPSPs during the application period, but this recovered only partially, to ∼80% of control levels, after washout lasting as long as 2 h. The lasting suppression had several properties in common with low-frequency stimulation induced long-term depression (LFS-LTD), including an ability to depotentiate long-term potentiated responses. However, DHO-LTD was insensitive to blockade of N-methyl-d-aspartate or mGlu receptors or to inhibitors of protein kinase C or p38 MAP kinase. DHO-LTD did not co-occlude with LFS-LTD and therefore appears to represent a novel form of LTD. Interestingly, DHO-LTD could be prevented by pretreating slices with iberiotoxin, the selective blocker of large, Ca2+-dependent K+ channels (“big K,” BK channels), although this toxin did not affect basal fEPSPs. Certain pathological conditions, including hypoxia and ischemia, are associated with a decrease in Na,K-pump activity and hence DHO-LTD may serve as a model for the effects on neuronal function in these conditions.

scholarly journals Catecholamine exocytosis during low frequency stimulation in mouse adrenal chromaffin cells is primarily asynchronous and controlled by the novel mechanism of Ca2+syntilla suppression

2014 ◽  
Vol 592 (21) ◽  
pp. 4639-4655 ◽  
Author(s):  
Jason J. Lefkowitz ◽  
Valerie DeCrescenzo ◽  
Kailai Duan ◽  
Karl D. Bellve ◽  
Kevin E. Fogarty ◽  
...  
Keyword(s):  
Chromaffin Cells ◽  
Low Frequency ◽  
The Novel ◽  
Adrenal Chromaffin Cells ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation ◽  
Adrenal Chromaffin
Sign in / Sign up

Export Citation Format

Share Document